Results 251 to 260 of about 45,545 (290)

The expression of Mas-receptor of the renin–angiotensin system in the human eye [PDF]

Graefe's Archive for Clinical and Experimental Ophthalmology, 2015
The local renin-angiotensin system has been held to be expressed in many organs, including the eye. It has an important role in the regulation of local fluid homeostasis, cell proliferation, fibrosis, and vascular tone. Mas-receptor (Mas-R) is a potential receptor acting mainly opposite to the well-known angiotensin II receptor type 1.
Vapaatalo H
exaly   +5 more sources

Mas receptor is involved in the estrogen-receptor induced nitric oxide-dependent vasorelaxation

Biochemical Pharmacology, 2017
The Mas receptor is involved in the angiotensin (Ang)-(1-7) vasodilatory actions by increasing nitric oxide production (NO). We have previously demonstrated an increased production of Ang-(1-7) in human umbilical vein endothelial cells (HUVEC) exposed to estradiol (E2), suggesting a potential cross-talk between E2 and the Ang-(1-7)/Mas receptor axis ...
Susana Novella, Ana Mompeón, CARLOS Bueno-Beti   +2 more
exaly   +5 more sources

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Mas receptor endocytosis and signaling in health and disease

2023
The renin angiotensin system (RAS) plays a major role in blood pressure regulation and electrolyte homeostasis and is mainly composed by two axes mediating opposite effects. The pressor axis, constituted by angiotensin (Ang) II and the Ang II type 1 receptor (AT1R), exerts vasoconstrictor, proliferative, hypertensive, oxidative and pro-inflammatory ...
Rukavina Mikusic, Natalia Lucía, Gironacci, Mariela Mercedes   +1 more
openaire   +3 more sources

The mas oncogene encodes an angiotensin receptor

Nature, 1988
The class of receptors coupled to GTP-binding proteins share a conserved structural motif which is described as a 'seven-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. Identified examples include the mammalian opsins, alpha 1-, alpha 2-, beta 1- and beta 2-adrenergic receptors, the ...
T R, Jackson, L A, Blair, J, Marshall, M, Goedert, M R, Hanley   +4 more
openaire   +2 more sources

Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison

Clinical Science, 2014
The angiotensin type 2 receptor (AT2R) and the receptor Mas are components of the protective arms of the renin–angiotensin system (RAS), i.e. they both mediate tissue protective and regenerative actions. The spectrum of actions of these two receptors and their signalling mechanisms display striking similarities. Moreover, in some instances, antagonists
Villela, Daniel, Leonhardt, Julia, Patel, Neal, Joseph, Jason, Kirsch, Sebastian, Hallberg, Anders, Unger, Thomas, Bader, Michael, Santos, Robson A, Sumners, Colin, Steckelings, Ulrike Muscha   +10 more
openaire   +4 more sources

The cardiac expression of Mas receptor is responsive to different physiological and pathological stimuli

Peptides, 2012
The Mas protooncogene encodes a G protein-coupled receptor that has been described as a functional receptor for the cardioprotective fragment of the renin-angiotensin system (RAS), Angiotensin (Ang)-(1-7).
Marco Fabricio Dias-Peixoto, Dirceu Sousa Melo, Maria JOSÉ Campagnole-Santos   +2 more
exaly   +2 more sources

Participation of AT1 and Mas receptors in the modulation of inflammatory pain

Peptides, 2014
We investigated the mechanisms underlying the endogenous control of nociception at the peripheral level during inflammation. We hypothesized that angiotensin receptors could modulate pain at the peripheral level via endogenous processes because angiotensin receptors are present in peripheral nerve terminals.
Aline C O, Costa, Thiago R L, Romero, Daniela F, Pacheco, Andrea C, Perez, Atila, Savernini, Robson R A, Santos, Igor D G, Duarte   +6 more
openaire   +2 more sources

Mas receptor contributes to pregnancy-induced cardiac remodelling

Clinical Science, 2016
Previous studies have demonstrated a protective effect of the Ang-(1–7)/Mas receptor axis on pathological cardiac hypertrophy. Also, the involvement of Mas receptor in exercise-induced cardiac hypertrophy has been suggested. However, the role of the Ang-(1–7)/Mas receptor on pregnancy-induced cardiac remodelling remains unknown.
Cintia, do Carmo E Silva, Jônathas Fernandes Queiroz, de Almeida, Larissa Matuda, Macedo, Marcos Barrouin, Melo, Gustavo Rodrigues, Pedrino, Fernanda Cristina Alcantara, Dos Santos, Manoel Francisco, Biancardi, Robson Augusto Souza, Dos Santos, Adryano Augustto Valladão, de Carvalho, Elizabeth Pereira, Mendes, Diego Basile, Colugnati, Renata, Mazaro-Costa, Carlos Henrique, de Castro   +12 more
openaire   +2 more sources

Expression of the Mas receptor is upregulated in skeletal muscle wasting

Histochemistry and Cell Biology, 2014
Skeletal muscle atrophy during sepsis, immobilization, and chronic diseases is characterized by an increase in expression and activity of the muscle-specific ubiquitin 3 ligases atrogin-1 and MuRF-1. The classical renin-angiotensin system (RAS), by high level of circulating angiotensin II (AngII) is directly involved in skeletal muscle wasting ...
María Gabriela, Morales, Johanna, Abrigo, Carla, Meneses, Franco, Cisternas, Felipe, Simon, Claudio, Cabello-Verrugio   +5 more
openaire   +2 more sources

Mas receptor: a potential strategy in the management of ischemic cardiovascular diseases

Cell Cycle, 2023
MasR is a critical element in the RAS accessory pathway that protects the heart against myocardial infarction, ischemia-reperfusion injury, and pathological remodeling by counteracting the effects of AT1R. This receptor is mainly stimulated by Ang 1-7, which is a bioactive metabolite of the angiotensin produced by ACE2.
Ali, Molaei, Emad, Molaei, A Wallace, Hayes, Gholamreza, Karimi   +3 more
openaire   +2 more sources