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Mas Receptor Agonists as Novel Antihypertensive Agents
Current Hypertension Reviews, 2012It is well known that the renin-angiotensin system (RAS) plays a pivotal role in the control of the cardiovascular and renal systems and in the pathogenesis of cardiovascular and renal diseases. The classical concept of the RAS has been changed in the recent years by the inclusion of novels components. Among the novel components of the RAS, Angiotensin(
Silvia Quintao Savergnini +3 more
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Pharmacology and Signaling of MAS-Related G Protein–Coupled Receptors
Pharmacological Reviews, 2014Signaling by heptahelical G protein-coupled receptors (GPCR) regulates many vital body functions. Consequently, dysfunction of GPCR signaling leads to pathologic states, and approximately 30% of all modern clinical drugs target GPCR. One decade ago, an entire new GPCR family was discovered, which was recently named MAS-related G protein-coupled ...
Hans Jürgen, Solinski +2 more
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Characterization and regulation of prolactin receptors in MA-10 Leydig cells
Molecular and Cellular Endocrinology, 1998The aim of this study is to further characterize the prolactin receptors (PRL-R) previously reported in the murine Leydig tumor MA-10 cell line, as well as to study their homologous and heterologous regulation. Two forms of PRL-R, a high and a low molecular weight form, were revealed by studies of covalent crosslinking of 125I-human GH to cultured MA ...
E, Weiss-Messer +3 more
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Mas and Its Related G Protein–Coupled Receptors, Mrgprs
Pharmacological Reviews, 2014The Mas-related G protein-coupled receptors (Mrgprs or Mas-related genes) comprise a subfamily of receptors named after the first discovered member, Mas. For most Mrgprs, pruriception seems to be the major function based on the following observations: 1) they are relatively promiscuous in their ligand specificity with best affinities for itch-inducing ...
Michael, Bader +3 more
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20-Hydroxyecdysone activates the protective arm of the RAAS via the MAS receptor
Journal of Molecular Endocrinology, 202220-Hydroxyecdysone (20E) is a steroid hormone that plays a key role in insect development through nuclear ecdysteroid receptors (EcR/RXR complex) and at least one membrane GPCR receptor (DopEcR). It also displays numerous pharmacological effects in mammals, where its mechanism of action is still debated, involving either an unidentified GPCR or the ...
René Lafont +9 more
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Mas receptors in modulating relaxation induced by perivascular adipose tissue
Life Sciences, 2011Perivascular adipose tissue (PVAT) is known to secrete vascular relaxation factors, and angiotensin 1-7 [Ang-(1-7)] acting on the endothelium is one of the endothelium-dependent relaxation factors. Mas protein is the receptor for Ang-(1-7). Using aorta from Mas-knockout (K/O) and wild type (FVB) mice, we wished to establish the essential role of Mas ...
Robert M K W, Lee +5 more
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Hypertension, 2013
The angiotensin AT2-receptor (AT2R) and the receptor MAS both mediate very similar tissue-protective actions. Furthermore, AT2R-antagonists have been reported to block effects of the MAS-agonist Ang 1-7. Therefore we speculated that a molecular association between these two receptors exists resulting in functional interactions.
Daniel Villela +10 more
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The angiotensin AT2-receptor (AT2R) and the receptor MAS both mediate very similar tissue-protective actions. Furthermore, AT2R-antagonists have been reported to block effects of the MAS-agonist Ang 1-7. Therefore we speculated that a molecular association between these two receptors exists resulting in functional interactions.
Daniel Villela +10 more
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Mas receptor blockade impairs exercise-induced cardiac hypertrophy
PeptidesExercise training leads to physiological cardiac hypertrophy and the protective axis of the renin-angiotensin system composed of angiotensin-converting enzyme 2, angiotensin-(1-7), and Mas receptor seems involved in this process. However, the role of the basal activity of the Mas receptor in exercise-induced physiological cardiac hypertrophy is still ...
Christoffer Novais de Farias, Silva +12 more
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Abstract P318: Signaling Pathways Triggered by the Mas Receptor
Hypertension, 2017Mas receptor (MasR) is a class A Orphan G-protein-coupled receptor (GPCR). Although angiotensin-(1-7) [Ang-(1-7)] has been reported as its putative ligand, the intracellular signaling pathways activated by the MasR remain only partially characterized.
Valeria Burghi +5 more
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The role of Mas receptors in an experimental rat glaucoma model
Acta Ophthalmologica, 2011AbstractPurpose To evaluate the neuroprotective and/or oculohypotensive effects of potent angiotensin system agents known to reduce intraocular pressure in the normotensive rabbits by using an experimental laser‐induced glaucoma model in rat eye.Methods Experimental glaucoma was induced unilaterally using laser photocoagulation of the episcleral and ...
A VAAJANEN +3 more
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