Results 241 to 250 of about 396,884 (345)

Aberrations in the glycosylation of receptor tyrosine kinases: A focus on lung adenocarcinoma.

Cytojournal
Dmitrieva AM, Kocak IG, Meder L.
europepmc   +1 more source

Protein Kinases as Mediators for miRNA Modulation of Neuropathic Pain. [PDF]

Cells
Chang L, Čok Z, Yu L.
europepmc   +1 more source

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

Advanced Science, EarlyView.
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan, Ning Wang, Bowen Xing, Min Yang, Jun Shang, Yufang Bao, Lixing Xiao, Ningxia Zhang, Yunpeng Ren, Chunnan Liu, Yuting Chen, Han Han, Yunjian Pan, Lei Lv, Wei‐Xing Zong, Hongbin Ji, Changyou Zhan, Zefeng Wang, Haiquan Chen, Yongbo Wang   +19 more
wiley   +1 more source

Kinase-Targeted Therapies for Glioblastoma. [PDF]

Int J Mol Sci
Salbini M, Formato A, Mongiardi MP, Levi A, Falchetti ML.   +4 more
europepmc   +1 more source

RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics

Advanced Science, EarlyView.
RAB5A‐mediated unjamming enhances active wetting through distinct biomechanical processes: a) upregulation of specific integrin subunits, enhanced focal adhesions kinetics and activity; b) supracellular organization relying on nanoscale integrin clustering, and the formation of a stiff and collective actin cable; and c) softening of the spheroid core ...
Grégoire Lemahieu, Paulina Moreno‐Layseca, Tobias Hub, Carlo Bevilacqua, Manuel Gómez‐González, Federica Pennarola, Federico Colombo, Andrew E. Massey, Leonardo Barzaghi, Andrea Palamidessi, Leon‐Luca Homagk, Samuel F. H. Barnett, Alexander X. Cartagena‐Rivera, Christine Selhuber‐Unkel, Robert Prevedel, Xavier Trepat, Joachim P. Spatz, Johanna Ivaska, Giorgio Scita, Elisabetta Ada Cavalcanti‐Adam   +19 more
wiley   +1 more source

Structural Identification of Major Molecular Determinants for Phosphotyrosine Recognition in Tyrosine Kinases Reveals Tumour Promoting and Suppressive Functions

Cheng N, Millán-Barea LR, Creixell M, Barr AR, Kong YW, Joughin BA, Lopez CK, Lengefeld J, Clarke J, Liu C, Sriram G, González-Robles TJ, van de Kooij B, Savickas S, Schoof EM, Johnson JL, Bakal C, Cantley LC, Chiarle R, Pritchard J, Hubbard S, Huntly BJ, Hemann M, Creixell P, Yaffe MB.   +24 more
europepmc   +1 more source

Chronic diseases alter the platelet rheostat to promote hyperreactivity and thrombosis. [PDF]

J Clin Invest
Silverstein RL.
europepmc   +1 more source

Mutation of tyrosine 318 (Y318F) in the delta-opioid receptor attenuates tyrosine phosphorylation, agonist-dependent receptor internalization, and mitogen-activated protein kinase activation

, 2000
H Kenneth Kramer, Matthew L. Andria, Stephanie A. Kushner, Diego Esposito, Jacob M. Hiller, Eric J. Simon   +5 more
openalex   +1 more source

Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis

Advanced Science, EarlyView.
The study in this paper found that activating the α2A receptors of astrocytes in the thoracic spinal cord can reduce the release of inflammatory factors, thereby decreasing the necroptosis of GABAergic neurons and consequently alleviating myocardial injury caused by sepsis.
Ruilin He, Bin Wu, Liuhu Han, Mingde Li, Wenli Guo, Jiajing Fu, Bin Mei, Eric R. Gross, Xuesheng Liu, Yao Lu   +9 more
wiley   +1 more source

Posttranslational modifications of YAP/TAZ: molecular mechanisms and therapeutic opportunities. [PDF]

Cell Mol Biol Lett
Zhang Z, He P, Yang L, Gong J, Qin R, Wang M.   +5 more
europepmc   +1 more source