Results 241 to 250 of about 290,363 (308)

LYN mutations in breast cancer: hypothesis-generating evidence for an association with central nervous system metastasis and domain-level insights. [PDF]

BMC Cancer
Çağdaş EK, Çağdaş B.
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

The Landscape of Genomic Alterations in Receptor Tyrosine Kinase Pathways in Biliary Cancers: Implications for Targeted Therapies. [PDF]

J Gastrointest Cancer
Voutsadakis IA.
europepmc   +1 more source

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science, EarlyView.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
wiley   +1 more source

Novel FAK inhibitors suppress tumor growth and reverse EGFR-TKI resistance in non-small cell lung cancer. [PDF]

Cancer Drug Resist
Xu G, Pecoraro C, Vahabi M, Deng D, Cavazzoni A, Fiuji H, Lagrasta CAM, Cascioferro SM, Tiseo M, Carbone D, Avan A, Zucali PA, Assaraf YG, Peters GJ, Diana P, Giovannetti E.   +15 more
europepmc   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

Serine/threonine kinase 32 family proteins: The potential multifaceted regulators in cancer. [PDF]

Transl Oncol
Liu L, Feng Y, Liu Y, Cheng L, Cheng P.
europepmc   +1 more source

The Inositol-5-Phosphatase SHIP1: Expression, Regulation and Role in Acute Lymphoblastic Leukemia. [PDF]

Int J Mol Sci
Ehm P, Jücker M.
europepmc   +1 more source

Small-molecule degron mimetics for targeted protein degradation. [PDF]

Essays Biochem
Liu X.
europepmc   +1 more source

Progressive Destructive Hypothyroidism Associated with Sunitinib Therapy: A Three-Year Case Analysis. [PDF]

J Clin Med
Nosal M.
europepmc   +1 more source