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Control of Lymphopoiesis by Non-Receptor Protein Tyrosine Kinases
1994Maintenance of a satisfactory immune system requires the daily generation of millions of lymphocytes from immature progenitor cells that reside (in adult mammals) in the bone marrow. Three fundamental processes underlie lymphopoiesis. First, a small population of hematopoietic stem cells (estimated to represent something less than 0.1% of bone marrow ...
R M, Perlmutter, S J, Anderson
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Non-receptor protein tyrosine kinases as immune targets of viruses
Immunology Today, 1997Abstract Non-receptor protein tyrosine kinases (NRPTKs) are critically involved in signaling pathways that modulate growth, differentiation and (mature) cell function. Here, Yves Collette and Daniel Olive reviaw the recently identified interactions of virus proteins from Herpesviridae, Retroviridae and Papavaviridae with NRPTKs, mid propose that these
Y, Collette, D, Olive
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Non-Receptor Protein Tyrosine Kinases and Phosphatases in Human Platelets
Thrombosis and Haemostasis, 1996There is now a large and rapidly growing body of information on the different types of non-receptor tyrosine kinases and phosphatases present within platelets. These enzymes appear to play a critical role in co-ordinating, integrating and amplifying signals from multiple cell surface receptors.
S P, Jackson +4 more
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The ErbB/HER receptor protein-tyrosine kinases and cancer
Biochemical and Biophysical Research Communications, 2004The ErbB/HER protein-tyrosine kinases, which include the epidermal growth factor receptor, consist of a growth-factor-binding ectodomain, a single transmembrane segment, an intracellular protein-tyrosine kinase catalytic domain, and a tyrosine-containing cytoplasmic tail.
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Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases
Trends in Cell Biology, 2001Signaling through receptor tyrosine kinases (RTKs) is a major mechanism for intercellular communication during development and in the adult organism, as well as in disease-associated processes. The phosphorylation status and signaling activity of RTKs is determined not only by the kinase activity of the RTK but also by the activities of protein ...
A, Ostman, F D, Böhmer
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Src-related protein tyrosine kinases and T-cell receptor signalling
Trends in Genetics, 1992Upon antigen stimulation, the T-cell receptor for antigen transduces an intracellular protein tyrosine phosphorylation signal that is critical for subsequent T-lymphocyte activation. As the antigen receptor does not possess an intrinsic protein tyrosine kinase activity, the mechanism by which it regulates protein tyrosine phosphorylation is ...
A, Veillette, D, Davidson
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Deceiving appearances: signaling by “dead” and “fractured” receptor protein-tyrosine kinases
BioEssays, 2000The mechanisms by which most receptor protein-tyrosine kinases (RTKs) transmit signals are now well established. Binding of ligand results in the dimerization of receptor monomers followed by transphosphorylation of tyrosine residues within the cytoplasmic domains of the receptors.
M, Kroiher, M A, Miller, R E, Steele
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Protein tyrosine kinase receptors.
Cancer surveys, 1997More than 50 PTK receptors are known to be involved in regulation of cell growth, differentiation, chemotaxis and actin reorganization. PTK receptors can be classified into subfamilies according to their structural features. PTK receptors are activated by ligand induced homo- or heterodimerization, which leads to receptor autophosphorylation on ...
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Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila
Current Opinion in Cell Biology, 1994The isolation and characterization of Drosophila mutations in receptor protein tyrosine kinases (RPTKs) have allowed a detailed analysis of the cellular processes regulated by these proteins. Recent investigations have identified a number of putative ligands involved in the activation of the receptors, and have demonstrated that these RPTKs trigger an ...
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Protein tyrosine kinases in the initiation of antigen receptor signaling
Current Opinion in Immunology, 1995Intracellular responses to antigen receptor engagement involve the activation of protein tyrosine kinases and the tyrosine phosphorylation of cellular proteins, including components of the antigen receptor. Phosphorylation of two tyrosine residues within an 18 amino acid segment of the cytoplasmic domain of antigen receptor subunits, and the subsequent
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