Results 251 to 260 of about 940,834 (307)

Oncogenic Receptor Tyrosine Kinases

2003
Polypeptide growth factors are relatively small and stable molecules that communicate short range signals for cell fate determination. Unlike steroid hormones, which penetrate through the plasma membrane due to their hydrophobic character, these factors must bind a cell surface-localized receptor.
Mina D. Marmor, Yosef Yarden, Mark H. Kirschbaum   +2 more
openaire   +2 more sources

Receptor Tyrosine Kinases in Angiogenesis

2002
Cell to cell communication is imperative for physiological and pathological processes associated with multicellular organisms. This is demonstrated in the process of angiogenesis where the blood vessel endothelial cells require signals generated from cells in the hypoxic tissue in order to initiate the process of forming new capillaries.
Kenneth E. Lipson, Laura Kay Shawver, Laurie M. Strawn, T. Annie T. Fong, Gerald Mcmahon   +4 more
openaire   +2 more sources

Receptor tyrosine kinases and the regulation of hematopoiesis

Seminars in Immunology, 1995
The ongoing production of mature blood cells during the lifetime of an animal is vital for survival. Hematopoiesis is the complex process whereby a small population of pluripotential stem cells give rise to mature cell types with specialized functions.
Alan Bernstein, Robert F. Paulson
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Autoinhibitory mechanisms in receptor tyrosine kinases

Frontiers in Bioscience, 2002
Receptor tyrosine kinases (RTKs) are single-pass transmembrane receptors that possess intrinsic tyrosine kinase catalytic activity in their cytoplasmic domains. RTKs are critical components in signal transduction pathways involved in cellular proliferation, differentiation, migration, and metabolism. This large protein family includes the receptors for
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Inhibitors of the insulin receptor tyrosine kinase

Pharmacology & Therapeutics, 1994
Insulin is a polypeptide hormone consisting of 51 amino acids. Insulin promotes a variety of anabolic enzymatic pathways and inhibits many catabolic enzymatic pathways involved in energy storage, as well as in synthesis of structural tissue proteins.
Pothur R. Srinivas, George Grunberger
openaire   +3 more sources

Tyrosine kinase receptor expression in thymomas

Journal of Cancer Research and Clinical Oncology, 2004
Promising new therapies for neoplasia include tyrosine kinase receptor antagonists. Tyrosine kinase oncogenes present an appealing anti-tumor drug target since they play an integral role in a variety of cellular responses including cell proliferation and differentiation.
Patrick J. Loehrer, John D. Henley, Oscar W. Cummings   +2 more
openaire   +3 more sources

The Insulin Receptor Tyrosine Kinase

1990
The insulin receptor is a tyrosine protein kinase. This enzymatic activity of the insulin receptor was first recognized in 1982, and is an initial, critical component of the mechanism by which insulin controls cell metabolism. Insulin binds to the extracellular domain of the receptor, activating the intracellular catalytic domain and triggering a ...
Morris F. White, Paul L. Rothenberg, C R Kahn   +2 more
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Evolution of Receptor Tyrosine Kinases

2014
Receptor tyrosine kinases (RTKs) hold a key position in the complex network of intercellular communication of multicellular organisms. The origins of the 58 RTKs in the human genome can therefore be traced back to the basis of metazoans. This chapter provides a reconstruction of the evolutionary history of the mammalian RTK repertoire and the ...
Jean-Nicolas Volff, Manfred Schartl, Frédéric Brunet   +2 more
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Endocytosis of Receptor Tyrosine Kinases

2008
Growth factors and their respective receptor tyrosine kinases (RTKs) play pivotal roles in normal cellular functions, such as proliferation and motility, as well as in pathogenesis, including cancer. The amplitude and kinetics of growth factor signaling are determined mainly by a highly regulated endocytic process, which sorts activated receptors to ...
Gal Gur, Yosef Yarden, Yaara Zwang
openaire   +2 more sources

Targeting Tyrosine Kinase Receptors

Blood, 2013
Abstract Protein tyrosine kinases (PTKs) regulate cell growth and other key functions. Constitutive PTK activation by somatic mutations, overexpression, or abnormal upstream signaling is characteristic of many cancers, including hematologic malignancies, providing a rationale for therapeutically targeting PTKs with small molecules ...
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