Results 11 to 20 of about 8,162 (160)
Current Biology, 2011 SummaryBeginning with the physical barrier presented by the epithelium, infectious agents such as viruses and bacteria encounter an array of cellular and molecular countermeasures that evolved within the host to resist them. Host immune responses are of two types, termed innate and adaptive.
Moresco, Eva Marie Y. +2 more
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Toll-like receptors and toll-like receptor-targeted immunotherapy against glioma [PDF]
Journal of Hematology & Oncology, 2021 AbstractGlioma represents a fast proliferating and highly invasive brain tumor which is resistant to current therapies and invariably recurs. Despite some advancements in anti-glioma therapies, patients’ prognosis remains poor. Toll-like receptors (TLRs) act as the first line of defense in the immune system being the detectors of those associated with ...
Yang Xun +3 more
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Toll-Like Receptor Signaling [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Toll-like receptors sense pathogen-associated molecular patterns (e.g., lipopolysaccharides) and trigger gene-expression changes that ultimately eradicate the invading microbes.
Kian-Huat, Lim, Louis M, Staudt
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Intracellular Toll-like Receptors [PDF]
Immunity, 2010 Foreign nucleic acids, the signature of invading viruses and certain bacteria, are sensed intracellularly. The nucleic acid-specific Toll-like receptors (TLRs) detect and signal within endolysosomal compartments, triggering the induction of cytokines essential for the innate immune response.
Blasius, Amanda L., Beutler, Bruce
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Toll-Like Receptor Signaling Pathways [PDF]
Frontiers in Immunology, 2014 Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns derived from various microbes. TLRs signal through the recruitment of specific adaptor molecules, leading to activation of the transcription factors NF-κB and IRFs, which dictate the outcome of innate immune responses.
Kawasaki, Takumi, Kawai, Taro
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Journal of the American Society of Nephrology, 2006 Innate and adaptive immunity have traditionally been considered as largely separate though complimentary mechanisms of defense against microbial threats. The adaptive system, being evolutionally newer and having the capacity for selectivity, adaptation, amplification, and memory, has arguably ...
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Revista Brasileira de Reumatologia, 2010 O sistema imunológico é constituído por uma intrincada rede de órgãos, células e moléculas e tem por finalidade manter a homeostase do organismo, combatendo as agressões em geral.
Alexandre Wagner Silva de Souza +6 more
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Aspectos fisiopatológicos del acné
Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica, 2014 El acné es una de las enfermedades más comunes en la consulta dermatológica, es más frecuente en jóvenes y se caracteriza por la presencia de pápulas, comedones y quistes en cara, pecho y espalda.
Arturo Argote +4 more
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, 2020 JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 18, Issue 12, Page 1470-1474, December 2020.
Dennis Niebel +3 more
wiley +1 more source
Japanese Journal of Clinical Immunology, 2005 Toll-like receptors (TLRs) have been revealed to recognize specific patterns of microbial components. Recognition of microbial components by TLRs initiates signal transduction pathways, triggering expression of genes, which products control innate immune responses and further instruct development of antigen-specific acquired immunity.
openaire +4 more sources