Results 1 to 10 of about 45,095 (165)

Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors

Biomolecules, 2020
It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA ...
Takahisa Hanada
exaly   +3 more sources

Regulating AMPA Receptors with Isoxazole-4-Carboxamide Derivatives: An Electrophysiological Study. [PDF]

J Xenobiot
Isoxazole carboxamide derivatives are intriguing modulators of ionotropic glutamate receptors; more specifically, their prospective analgesic activities based on non-opioid pathways have sparked widespread research.
Qneibi M, Hawash M, Bdir S, Bdair M, Idais T, Sarhan I, Touqan J.   +6 more
europepmc   +2 more sources

The essential role of AMPA receptor GluR2 subunit RNA editing in the normal and diseased brain

Frontiers in Molecular Neuroscience, 2012
AMPA receptors are comprised of different combinations of GluR1-GluR4 (also known as GluA1-GluA4 and GluR-A to GluR-D) subunits. The GluR2 subunit is subject to Q/R site RNA editing by the ADAR2 enzyme, which converts a codon for glutamine (Q), present ...
Amanda L Wright, Bryce Vissel
exaly   +3 more sources

α-Lipoic Acid Derivatives as Allosteric Modulators for Targeting AMPA-Type Glutamate Receptors’ Gating Modules

Cells, 2022
The ionotropic glutamate receptor subtype α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) is responsible for most excitatory transmission in the brain.
Mohammad Qneibi, Safa’ Nassar, Sosana Bdir, Adel Hidmi   +3 more
doaj   +1 more source

SynDIG1 promotes excitatory synaptogenesis independent of AMPA receptor trafficking and biophysical regulation. [PDF]

PLoS ONE, 2013
AMPA receptors-mediators of fast, excitatory transmission and synaptic plasticity in the brain-achieve great functional diversity through interaction with different auxiliary subunits, which alter both the trafficking and biophysical properties of these ...
Kathryn L Lovero, Sabine M Blankenship, Yun Shi, Roger A Nicoll   +3 more
doaj   +1 more source

Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis

Cell Reports, 2023
Summary: The recruitment of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors underlies the strengthening of neuronal connectivity during learning and memory. This process is triggered by N-methyl-D-aspartate (NMDA) receptor-
Jing Zhi Anson Tan, Se Eun Jang, Ana Batallas-Borja, Nishita Bhembre, Mintu Chandra, Lingrui Zhang, Huimin Guo, Mitchell T. Ringuet, Jocelyn Widagdo, Brett M. Collins, Victor Anggono   +10 more
doaj   +1 more source

Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation. [PDF]

PLoS ONE, 2012
Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane accessory proteins.
Artur Semenov, Tommi Möykkynen, Sarah K Coleman, Esa R Korpi, Kari Keinänen   +4 more
doaj   +1 more source

Fear Memory Retrieval Is Associated With a Reduction in AMPA Receptor Density at Thalamic to Amygdala Intercalated Cell Synapses

Frontiers in Synaptic Neuroscience, 2021
The amygdala plays a crucial role in attaching emotional significance to environmental cues. Its intercalated cell masses (ITC) are tight clusters of GABAergic neurons, which are distributed around the basolateral amygdala complex.
Anna Seewald, Sabine Schönherr, Heide Hörtnagl, Ingrid Ehrlich, Ingrid Ehrlich, Claudia Schmuckermair, Francesco Ferraguti   +6 more
doaj   +1 more source

Auxiliary Subunits Control Function and Subcellular Distribution of AMPA Receptor Complexes in NG2 Glia of the Developing Hippocampus

Frontiers in Cellular Neuroscience, 2021
Synaptic and axonal glutamatergic signaling to NG2 glia in white matter is critical for the cells’ differentiation and activity dependent myelination. However, in gray matter the impact of neuron-to-NG2 glia signaling is still elusive, because most of ...
Stefan Hardt, Dario Tascio, Stefan Passlick, Aline Timmermann, Ronald Jabs, Christian Steinhäuser, Gerald Seifert   +6 more
doaj   +1 more source

Sequential Activation of AMPA Receptors and Glial Cells in a Pain Model of Lumbar Spine Disc Herniation [PDF]

Annals of Rehabilitation Medicine, 2020
Objective To investigate the glial cell and AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor activity after surgery for disc herniation pain model.
Dong Gyu Kwak, Dong Gyu Lee
doaj   +1 more source