Results 111 to 120 of about 2,321,962 (333)
Method for identification of condition-associated public antigen receptor sequences [PDF]
eLife 2018;7:e33050, 2017 Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences.
arxiv +1 more source
Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons [PDF]
, 2006 We examined the effects of the chemokine fractalkine (CX3CL1) on EPSCs evoked by electrical stimulation of Schaffer collaterals in patch-clamped CA1 pyramidal neurons from rat hippocampal slices.
BERTOLLINI, Cristina +8 more
core +1 more source
Epilepsy Currents, 2013 Commentary The α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-type glutamate receptors (AMPAR) are normally assembled from GluA subunits 1–4 into tetrameric heteromers containing GluA2 within the endoplasmic reticulum.
Tim Benke
semanticscholar +1 more source
Assembly and Stoichiometry of the AMPA Receptor and Transmembrane AMPA Receptor Regulatory Protein Complex [PDF]
The Journal of Neuroscience, 2010 Glutamate is a major excitatory neurotransmitter in the vertebrate brain. AMPA-type glutamate receptors mediate fast excitatory transmission. AMPA receptors assemble with transmembrane AMPA receptor regulatory protein (TARP) auxiliary subunits and function as native ion channels.
Susumu Tomita, Kwang S. Kim, Dan Yan
openaire +3 more sources
Desensitization dynamics of the AMPA receptor
Structure, 2023 To perform their physiological functions, amino methyl propionic acid receptors (AMPARs) cycle through active, resting, and desensitized states, and dysfunction in AMPAR activity is associated with various neurological disorders. Transitions among AMPAR functional states, however, are largely uncharacterized at atomic resolution and are difficult to ...
Jussi Aittoniemi +3 more
openaire +2 more sources
Regulation of PVT‐CeA Circuit in Deoxynivalenol‐Induced Anorexia and Aversive‐Like Emotions
Advanced Science, EarlyView.The study investigates Deoxynivalenol (DON) effects on feeding and emotions, focusing on the central amygdala (CeA). Acute DON exposure reduces food intake and alters behavior, linked to CeAGABA neuron activity and PVT‐CeA connectivity. Manipulating CeAGABA neurons and using SCN10A antagonist A‐803467 alleviate DON's effects, offering potential ...
Liu‐Nan Yang +4 more
wiley +1 more source
Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]
Progress in Neurobiology 72(6), pp 399-415, April 2004, 2004 Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release. Even though NM receptor regulation is implicated in the pharmacological action of many drugs, and is also known to be influenced by various environmental ...
arxiv +1 more source
Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]
, 2010 L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A. +4 more
core +1 more source
Advanced Intelligent Systems, EarlyView.This article describes the spiking implementation of an arithmetic logic unit, the fundamental basis of which lies in the use of spiking logic gates. An extensive series of experiments validates the implemented designs on SpiNNaker and Dynap‐SE. This work takes a first step in the implementation of a spiking central processing unit.
Alvaro Ayuso‐Martinez +5 more
wiley +1 more source
Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses
Frontiers in Molecular Neuroscience, 2018 Synaptic scaling is a form of homeostatic plasticity that is critical for maintaining neuronal activity within a dynamic range, and which alters synaptic strength through changes in postsynaptic AMPA-type glutamate receptors.
Susana R. Louros +3 more
doaj +1 more source