Results 111 to 120 of about 86,953 (229)

Multi‐Channel Neural Interface for Neural Recording and Neuromodulation

Small Methods, EarlyView.
This review highlights recent advances in multi‐channel neural interface technologies, covering both high‐resolution electrophysiological recording systems and multifunctional platforms with integrated capabilities. It also discusses innovations in structure and materials for reduced invasiveness, state‐of‐the‐art data analysis, including machine ...
Eunmin Kim, Won Gi Chung, Enji Kim, Myoungjae Oh, Joonho Paek, Taekyeong Lee, Dayeon Kim, Seung Hyun An, Sumin Kim, Jang‐Ung Park   +9 more
wiley   +1 more source

Аlterationdegree of NMDA and AMPA receptors of glutamate in the pathogenesis of the disease and technological peculiarities of surgical treatment of the hemispheric glioma-swith the epileptic syndrome

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2014
The development of effective approaches to the treatment of patients with symptomatic tumor epilepsy was determined by the level of our fundamental knowledge of the basic mechanisms of epileptogenesis on cellular and molecular level.
V. N. Ochkolyas, M. B. Volov
doaj   +1 more source

Mechanism of Ammonia‐Induced Brain Damage in Chinese Striped‐Necked Turtle (Mauremys sinensis)

Integrative Zoology, EarlyView.
High levels of ammonia disrupt the integrity of the brain barrier in Mauremys sinensis, leading to tissue edema. This, in turn, triggers a series of cascade reactions, including disturbances in neurotransmitter levels, particularly glutamate, which might further exacerbate the neurotoxic effects.
Yunjuan Xiao, Xin Niu, Xueting Jiao, Liangping Lin, Haitao Shi, Meiling Hong, Li Ding   +6 more
wiley   +1 more source

A novel therapeutic approach for treatment of catamenial epilepsy

Neurobiology of Disease, 2018
Many women with epilepsy experience perimenstrual seizure exacerbation, referred to as catamenial epilepsy. There is no effective treatment for this condition, proposed to result from withdrawal of neurosteroid-mediated effects of progesterone.
Suchitra Joshi, Huayu Sun, Karthik Rajasekaran, John Williamson, Edward Perez-Reyes, Jaideep Kapur   +5 more
doaj   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Postsynaptic protein organization revealed by electron microscopy. [PDF]

, 2019
Neuronal synapses are key devices for transmitting and processing information in the nervous system. Synaptic plasticity, generally regarded as the cellular basis of learning and memory, involves changes of subcellular structures that take place at the ...
Bi, Guo-Qiang, Lau, Pak-Ming, Liu, Yun-Tao, Tao, Chang-Lu, Zhou, Z Hong   +4 more
core  

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source