Results 121 to 130 of about 2,321,962 (333)
Acute inactivation of PSD-95 destabilizes AMPA receptors at hippocampal synapses. [PDF]
PLoS ONE, 2013 Postsynatptic density protein (PSD-95) is a 95 kDa scaffolding protein that assembles signaling complexes at synapses. Over-expression of PSD-95 in primary hippocampal neurons selectively increases synaptic localization of AMPA receptors; however, mice ...
Guillermo A Yudowski +4 more
doaj +1 more source
Biomolecules, 2023 Dopamine (DA) and glutamate interact, influencing neural excitability and promoting synaptic plasticity. However, little is known regarding the molecular mechanisms underlying this crosstalk.
Giorgia Targa +5 more
doaj +1 more source
AGAP3 and Arf6 Regulate Trafficking of AMPA Receptors and Synaptic Plasticity
Journal of Neuroscience, 2013 During NMDA receptor-mediated long-term potentiation (LTP), synapses are strengthened by trafficking AMPA receptors to the synapse through a calcium-dependent kinase cascade following activation of NMDA receptors.
Y. Oku, R. Huganir
semanticscholar +1 more source
Animal Models and Experimental Medicine, EarlyView.Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam +13 more
wiley +1 more source
Differential inhibition by trifluoperazine of responses of hippocampal CA1 pyramidal cells to NMDA and AMPA in vivo [PDF]
, 2011 The effects of trifuoperazine (TFP), a phenothiazine neuroleptic drug having potent anticalmodulin activity, were studied on the responses of hippocampal CA1 pyramidal cells to N-methyl-D-aspartic acid (NMDA) and (RS)-A-amino-3-hydroxy-5-methyl-4 ...
Budai, Dénes
core
Neuropharmacological targets for drug action in vestibular sensory pathways [PDF]
, 2017 The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that ...
Jones, Timothy A, Lee, Choongheon
core +3 more sources
Journal of Neuroscience, 2013 More than 30 mutations in LGI1, a secreted neuronal protein, have been reported with autosomal dominant lateral temporal lobe epilepsy (ADLTE). Although LGI1 haploinsufficiency is thought to cause ADLTE, the underlying molecular mechanism that results in
Toshika Ohkawa +8 more
semanticscholar +1 more source
Nicotinic control of glutamate receptor trafficking [PDF]
, 2012 Nicotinic cholinergic signaling acting through nicotinic acetylcholine receptors influences numerous cognitive functions including learning and memory. Critical for these higher brain functions are basic attributes of excitatory transmission that depend ...
Halff, Andrew William
core
PhotonSABER: new tool shedding light on endocytosis and learning mechanisms in vivo
Communicative & Integrative Biology, 2019 In the central nervous system, activity-dependent endocytosis of postsynaptic AMPA-type glutamate receptors (AMPA receptors) is thought to mediate long-term depression (LTD), which is a synaptic plasticity model in various neuronal circuits.
Shinji Matsuda +2 more
doaj +1 more source
Selective disruption of stimulus-reward learning in glutamate receptor gria 1 knockout mice. [PDF]
, 2003 Glutamatergic neurotransmission via AMPA receptors has been an important focus of studies investigating neuronal plasticity. AMPA receptor glutamate receptor 1 (GluR1) subunits play a critical role in long-term potentiation (LTP).
Mead, Andy N, Stephens, David N
core +2 more sources