Results 161 to 170 of about 2,321,962 (333)
Modulating Excitatory Synaptic Neurotransmission: Potential Treatment for Neurological Disease?
Neurobiology of Disease, 1998 Excitatory neurotransmission at many CNS synapses depends upon AMPA-type glutamate receptors. Derangements in AMPA receptor-mediated synaptic transmission may be a contributing factor in neurological and neurodegenerative diseases and could be a target ...
Kelvin A. Yamada
doaj
SARM1 is essential for NMDA receptor-dependent endocytosis of AMPA receptors in hippocampal neurons
Neuroscience ResearchLong-term depression (LTD) is a form of synaptic plasticity thought to be the cellular basis of experience-dependent learning and memory. LTD is caused by an activity-dependent decrease in cell surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Misaki Morishita, Shinji Matsuda
doaj
Structure and dynamics of dynorphin peptide and its receptor [PDF]
arXiv, 2019 Dynorphin is a neuropeptide involved in pain, addiction and mood regulation. It exerts its activity by binding to the kappa opioid receptor (KOP) which belongs to the large family of G-protein coupled receptors. The dynorphin peptide was discovered in 1975, while its receptor was cloned in 1993.
arxiv
The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons [PDF]
, 2017 The cellular prion protein (PrPC) whose conformational misfolding leads to the production of deadly prions, has a still-unclarified cellular function despite decades of intensive research.
Bertoli, Alessandro +8 more
core +1 more source
Trafficking of AMPA Receptors at Plasma Membranes of Hippocampal Neurons
Journal of Neuroscience, 2011 The number of AMPA receptors at synapses depends on receptor cycling. Because receptors diffuse rapidly in plasma membranes, their exocytosis and endocytosis need not occur near synapses.
J. Tao-Cheng +5 more
semanticscholar +1 more source
Elucidating the Three‐Dimensional Structure of Piracetam through Rotational Spectroscopy
ChemistryOpen, EarlyView.Neutral molecules of the nootropic drug piracetam are generated by laser ablation and structurally characterized by microwave spectroscopy. Two conformers differing in the exo/endo configuration of the pyrrolidine ring are detected, with exo being the predominant form.
S. Mato +4 more
wiley +1 more source
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2014 The development of effective approaches to the treatment of patients with symptomatic tumor epilepsy was determined by the level of our fundamental knowledge of the basic mechanisms of epileptogenesis on cellular and molecular level.
V. N. Ochkolyas, M. B. Volov
doaj +1 more source
AMPA Receptor Phosphorylation and Synaptic Colocalization on Motor Neurons Drive Maladaptive Plasticity below Complete Spinal Cord Injury. [PDF]
, 2015 Clinical spinal cord injury (SCI) is accompanied by comorbid peripheral injury in 47% of patients. Human and animal modeling data have shown that painful peripheral injuries undermine long-term recovery of locomotion through unknown mechanisms ...
Beattie, Michael S +7 more
core +1 more source
Postsynaptic Synaptotagmins Mediate AMPA Receptor Exocytosis During LTP
Nature, 2017 Strengthening of synaptic connections by NMDA (N-methyl-d-aspartate) receptor-dependent long-term potentiation (LTP) shapes neural circuits and mediates learning and memory.
Dick Wu +8 more
semanticscholar +1 more source
Pediatric Investigation, EarlyView.The 50% responder rate and seizure freedom rate after 6 months of PER treatment during routine clinical care were 70.4% and 22.1%, respectively. The 50% responder rates for the 3 age‐based cohorts were 64.5% in infants and young children, 73.4% in children and 69.2% in adolescents, and the Seizure‐freedom rates were 16.1%, 23.7% and 25.6% respectively.
Xiaohui Wang +20 more
wiley +1 more source