Linking Age Changes in Human Cortical Microcircuits to Impaired Brain Function and EEG Biomarkers
Aging Cell, Volume 25, Issue 1, January 2026.We integrated human data of aging‐related reductions in inhibition, NMDA function, and dendritic spines into detailed models of cortical microcircuits. Simulations showed that the cellular aging mechanisms accounted for many of the age‐related changes seen in human EEG and could be estimated accurately using machine learning from their EEG biomarkers ...
Alexandre Guet‐McCreight +3 more
wiley +1 more source
Altered Excitability and Glutamatergic Synaptic Transmission in the Medium Spiny Neurons of the Nucleus Accumbens in Mice Deficient in the Heparan Sulfate Endosulfatase <i>Sulf1</i>. [PDF]
eNeuroMiya K +6 more
europepmc +1 more source
Brain Pathology, Volume 36, Issue 1, January 2026.Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li +7 more
wiley +1 more source
Modular Model of Neuronal Activity That Captures the Dynamics of Main Molecular Targets of Antiepileptic Drugs. [PDF]
Int J Mol SciKondrakhin PY, Kolpakov FA.
europepmc +1 more source
The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse. [PDF]
, 2007 Erazo Fischer, E.
core +1 more source
Electrical Synapses Contribute to Sleep‐Dependent Declarative Memory Retention
European Journal of Neuroscience, Volume 63, Issue 2, January 2026.Blocking electrical synapses (gap junctions) in healthy humans by mefloquine impaired the sleep‐dependent retention of verbal declarative memory and improved sensorimotor memory consolidation irrespective of sleep. Mefloquine also disrupted the coupling of sleep spindles to EEG slow oscillations in humans but did not affect hippocampal sharp‐wave ...
Gordon B. Feld +9 more
wiley +1 more source
Modulation of Metabotropic Glutamate Receptors as a Strategy to Improve the Efficacy and Safety of Ketamine as an Antidepressant. [PDF]
CellsPałucha-Poniewiera A.
europepmc +1 more source
Journal of Neurochemistry, Volume 170, Issue 1, January 2026.General anesthetics suppress cortical activity, but their cellular mechanisms remain unclear. We investigated how the volatile anesthetic sevoflurane affects layer 5 pyramidal neurons in the auditory cortex. Using patch‐clamp recordings and computational modeling, we found that low‐dose sevoflurane reduces neuronal firing through Kv1.2 channel ...
Aelton S. Araujo +4 more
wiley +1 more source
Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.Abstract Median preoptic nucleus (MnPO) neurons projecting to the hypothalamic paraventricular nucleus (PVN) are linked to hypertension induced by chronic intermittent hypoxia (CIH), a model of obstructive sleep apnea. The modulation of MnPO‐driven synaptic activity in PVN magnocellular neurons (MNCs) by CIH remains unexamined.
Obed T. Paundralingga +4 more
wiley +1 more source
The Stress Response Is Adaptive in a Context- and State-Dependent Manner. [PDF]
CellsKrugers HJ, Joëls M.
europepmc +1 more source