Results 71 to 80 of about 55,538 (273)
mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling
Advanced Science, EarlyView.Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim +4 more
wiley +1 more source
Pharmacological analysis of ionotropic glutamate receptor function in neuronal circuits of the zebrafish olfactory bulb. [PDF]
PLoS ONE, 2008 Although synaptic functions of ionotropic glutamate receptors in the olfactory bulb have been studied in vitro, their roles in pattern processing in the intact system remain controversial.
Rico Tabor, Rainer W Friedrich
doaj +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Rheumatoid arthritis (RA) is characterized by anti‐modified protein antibodies (AMPAs), including anti‐citrullinated (ACPA), anti‐carbamylated (anti‐CarP), and anti‐acetylated (AAPA) protein antibodies. In contrast to other AMPAs, AAPA IgM is found in healthy individuals, raising questions about its role in early immune responses.
Aegli Athanasiadou +10 more
wiley +1 more source
Cell Reports, 2017 Regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking in response to neuronal activity is critical for synaptic function and plasticity.
Sylvia Pfennig +6 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims This study aimed to investigate a set of pharmacodynamic biomarkers reflecting acute, delayed and sustained central nervous system effects of S‐ketamine, used as a tool compound for rapid‐acting antidepressant activity, with the goal of informing biomarker strategies for delayed antidepressant effects.
Catherine M. K. E. de Cuba +11 more
wiley +1 more source
The essential role of AMPA receptor GluR2 subunit RNA editing in the normal and diseased brain
Frontiers in Molecular Neuroscience, 2012 AMPA receptors are comprised of different combinations of GluR1-GluR4 (also known as GluA1-GluA4 and GluR-A to GluR-D) subunits. The GluR2 subunit is subject to Q/R site RNA editing by the ADAR2 enzyme, which converts a codon for glutamine (Q), present ...
Amanda Lorraine Wright +3 more
doaj +1 more source
Mechanisms of AMPA Receptor Endosomal Sorting [PDF]
Frontiers in Molecular Neuroscience, 2018 The regulation of synaptic AMPA receptors (AMPARs) is critical for excitatory synaptic transmission, synaptic plasticity and the consequent formation of neural circuits during brain development and their modification during learning and memory processes.
Parkinson, Gabrielle T. +1 more
openaire +5 more sources
Molecular characterisation of neurotransmitter receptors in the CNS of the stargazer mutant mouse [PDF]
, 2002 The mutant mouse stargazer shows both ataxia and absence epilepsy from P14 onwards. A PGR amplification strategy was utilised to identify adult (i.e. > 3 months) +/stg from +/+ mice, which share the same phenotype, for use for breeding purposes. The same
Tiwari, Priyanka
core
Role of AMPA receptors in synaptic plasticity
, 2006 The a (alpha−)−amino−3−hydroxy−5−methyl−4−isoxazolepropionic acid (AMPA) receptors are the principal molecular units for fast excitatory synaptic transmission in the central nervous system.
Sprengel, Rolf, Sprengel, R.
core +1 more source
In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans
Cytoskeleton, EarlyView.ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley +1 more source