Results 101 to 110 of about 669,213 (305)

Expression of androgen, estrogen, and progesterone hormone receptors in the penile tissues of children with different types of hypospadias

İstanbul Kuzey Klinikleri, 2019
INTRODUCTION[|]Androgen (AR), Estrogen (ER) and Progesterone (PR) hormones play an important role in the prenatal and postnatal development of urogenital tract and especially the penis.
Ayşenur Celayir, Serdar Moralıoğlu, Handan Cetiner, Gözde Kır, Sinan Celayir   +4 more
doaj   +1 more source

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source

Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]

, 2010
Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core  

Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development [PDF]

, 2010
Peer ...
Richard M. Sharpe, Philippa T K Saunders, Sergio R. Batlouni, Batlouni, Sergio R., Luiz R França, Esnal, Arantza; id_orcid, Batlouni, Sergio R. [UNESP], Karel De Gendt, Arantza Esnal, Esnal Arantza, Verhoeven Guido, Batlouni, Sergio R, De Gendt Karel, Philippa T. K. Saunders, Johannes V Swinnen, Swinnen, Johannes V., Saunders Philippa T. K., Johannes V. Swinnen, Sergio R Batlouni, Saunders, Philippa T K; id_orcid, França Luiz R., Richard M Sharpe, França, Luiz R, Saunders, Philippa T. K., Saunders, Philippa T.K., Sharpe, Richard M, Luiz R. França, Guido Verhoeven, Sharpe Richard M., Saunders, Philippa T K, Ariane Willems, Sharpe, Richard M., Batlouni Sergio R., Swinnen, Johannes V, Swinnen Johannes V., Willems, Ariane, Esnal, Arantza, Verhoeven, Guido, De Gendt, Karel, Swinnen, Johan, Franca, Luiz R., Willems Ariane   +41 more
core   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Evidence for a GABAergic system in rodent and human testis: Local GABA production and GABA receptors [PDF]

, 2003
The major neurotransmitter of the central nervous system, gamma-aminobutyric acid (GABA), exerts its actions through GABA(A), GABA(B) and GABA(C) receptors.
Doepner, Richard F. G., Frungieri, Monica Beatriz, Kohn, Frank M., Doepner, R., Gamel-Didelon, Katia, Geigerseder, C., Mayerhofer, Artur, Thalhammer, A,, Geigerseder, Christof, Frungieri, Monica B., Köh, F. M., Calandra, Ricardo Saul, Calandra, Ricardo S., Gamel Didelon, K., Thalhammer, Andrea, Geigerseder, Christof;Doepner, Richard;Thalhammer, Andrea;Frungieri, Monica B.;Gamel-Didelon, Katia;Calandra, Ricardo S.;Köhn, Frank M.;Mayerhofer, Artur, Geigerseder, C;Doepner, R;Thalhammer, A;Frungieri, MB;Gamel-Didelon, K;Calandra, RS;Köhn, FM;Mayerhofer, A   +16 more
core   +1 more source

Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control

Advanced Science, EarlyView.
Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang, Xiangyang Zhan, Jiexiang Zhang, Mingyue Tan, Chuanmin Chu, Guanqun Ju, Xinyu Zhai, Jianyi Gu, Huirong Zhu, Dongliang Xu   +9 more
wiley   +1 more source