Results 81 to 90 of about 669,213 (305)

Lipid Metabolic Disorders in Neurodegenerative Diseases – Role of Androgen Receptor

Eurasian Journal of Medicine, 2023
The challenge of managing neurodegenerative disorders is a worldwide concern, especially in the aging population. Neurodegenerative diseases are a varied group of disorders that are characterized by progressive degeneration of the structure and function
Satvika Sharma, Avneet Saini, D.K. Dhawan   +2 more
doaj   +1 more source

The androgen/androgen receptor axis in prostate cancer [PDF]

Current Opinion in Oncology, 2012
The review highlights recently discovered mechanisms that sustain castration-resistant prostate cancer (CRPC) growth and describes advances in CRPC therapeutics.Recent reports have shed new light on the molecular processes underlying CRPC survival during androgen deprivation therapy (ADT).
Eric G, Bluemn, Peter S, Nelson
openaire   +2 more sources

Could Testosterone Have a Therapeutic Role in Prostate Cancer?

Urology Journal, 2013
PURPOSE:To discuss the role of membrane androgen receptors and to investigate the potential role of testosterone-albumin conjugate in the prostate cancer (PCa) treatment.MATERIALS AND METHODS: We identified studies published from 1990 onwards by ...
Konstantinos Stamatiou
doaj  

The Effect of Estradiol and Testosterone Levels Alone or in Combination with Their Receptors in Predicting the Severity of Systemic Lupus Erythematosus: A Cohort Study [PDF]

Iranian Journal of Medical Sciences
Background: Developing a practical method to predict active systemic lupus erythematosus (SLE) in patients with inactive/mild status at the onset of the disease could lead to appropriate treatment that ultimately prevents future relapses. The development
Samaneh Abdolahpour, Nafiseh Abdolahi, Mehrdad Aghaei, Hossein Azadeh, Touraj Farazmandfar   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Pre-receptor regulation of the androgen receptor [PDF]

Molecular and Cellular Endocrinology, 2008
The human androgen receptor (AR) is a ligand-activated nuclear transcription factor and mediates the induction of genes involved in the development of the male phenotype and male secondary sex characteristics, as well as the normal and abnormal growth of the prostate.
Trevor M, Penning, Yi, Jin, Tea Lanisnik, Rizner, David R, Bauman   +3 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Expression of Androgen Receptor in Human Placentas from Normal and Preeclamptic Pregnancies

Taiwanese Journal of Obstetrics & Gynecology, 2009
Objective: To elucidate the expression of androgen receptor (AR) in human placenta from normal and preeclamptic (PE) pregnancies. Materials and Methods: This study was performed at the Division of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial ...
Te-Yao Hsu, Kuo-Chung Lan, Chih-Chang Tsai, Chi-Yu Ou, Bi-Hua Cheng, Men-Yin Tsai, Hong-Yo Kang, Yu-Hsia Tung, Yi-Hush Wong, Ko-En Huang   +9 more
doaj   +1 more source

Prostate cancer and therapeutic challenges

Journal of Biological Research - Thessaloniki, 2020
Prostate cancer (PC) is the most prevalent type of cancer in men worldwide. In Saudi Arabia, the rate of PC is increasing annually. The sex steroid hormones androgens and their receptors have critical roles in PC development and progression. Additionally,
Yousef MohammedRabaa Hawsawi, Samar Abdullah Zailaie, Atif Abdulwahab A. Oyouni, Othman Rashed Alzahrani, Osama Mohamed Alamer, Saad Ali S. Aljohani   +5 more
doaj   +1 more source