Results 81 to 90 of about 78,518 (314)

Clinical, Hormonal and Genetics Features in patients with Androgen Insensitivity Syndrome in Cytogenetic Laboratories in Semarang [PDF]

, 2006
Androgen insensitivity syndrome (AIS) is an X-linked disorder caused by impaired Androgen Receptor (AR) which is encoded in Xq 11-12. In this condition, although the androgen is produced sufficiently, but the peripheral masculinizing effect is blocked ...
Tonang, Alvin
core  

The impact of point mutations in the human androgen receptor : classification of mutations on the basis of transcriptional activity [PDF]

, 2012
Peer ...
Iain J McEwan, Colin W. Hay (179733), McEwan, Iain J, Colin W Hay, Hay, Colin W, McEwan Iain J., Hay Colin W., Iain J. McEwan (179736)   +7 more
core   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Androgens and the androgen receptor (AR)

, 2013
Introduction Androgens are sex steroid hormones that are produced in both males and females, albeit in different amounts. Androgens are essential for development and maintenance of the male phenotype (1), and are also important in females, where they can either act directly via the androgen receptor (AR) or indirectly as metabolic precursors for ...
Moore, N., Centenera, M., Butler, L., Hickey, T., Tilley, W.   +4 more
openaire   +2 more sources

A computational model of the hypothalamic - pituitary - gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone [PDF]

, 2011
© 2011 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Watanabe, Karen H, Watanabe, KH, Mitchell Kostich, Villeneuve, DL, Kostich, M, Li, Zhenhong, Zhenhong Li, Sepúlveda, MS, Jensen, Kathleen M, Villeneuve, Daniel L, Daniel L Villeneuve, María S Sepúlveda, Gerald T Ankley, Kathleen M Jensen, Ankley, GT, Nancy D Denslow, Kroll, KJ, Brandon Armstrong, James M Lazorchak, Brian, JV, Brian, Jayne V, Orlando, Edward F, Denslow, ND, Orlando, EF, Ankley, Gerald T, Armstrong, B, Lazorchak, JM, Sepulveda, Maria S, Jayne V Brian, Karen H Watanabe, Lazorchak, James M, Li, Z, Edward F Orlando, Kroll, Kevin J, Jensen, KM, Denslow, Nancy D, Kostich, Mitchell, Armstrong, Brandon, Kevin J Kroll   +38 more
core   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Study of Validity of PC-3 Derived Xenograft Tumor Model in Athymic Nude Mice for Targeting Therapy of Androgen Receptors in Preclinical Studies of Prostate Cancer

Basic & Clinical Cancer Research, 2016
Background: Androgen receptors (AR) play an important role in proliferation of cancerous prostatic cells and prevention of apoptotic signaling. Current drugs cannot inhibit the activity of these receptors very well.
Samad Muhammadnejad, Ahad Muhammadnejad, Zohreh Mazaheri, Farrokh Tirgari, Mohammad-Ali Oghabian, Maryam Kazem haghighi, Saeid Amanpour   +6 more
doaj  

Expression of androgen, estrogen, and progesterone hormone receptors in the penile tissues of children with different types of hypospadias

İstanbul Kuzey Klinikleri, 2019
INTRODUCTION[|]Androgen (AR), Estrogen (ER) and Progesterone (PR) hormones play an important role in the prenatal and postnatal development of urogenital tract and especially the penis.
Ayşenur Celayir, Serdar Moralıoğlu, Handan Cetiner, Gözde Kır, Sinan Celayir   +4 more
doaj   +1 more source