The androgen/androgen receptor axis in prostate cancer [PDF]
Current Opinion in Oncology, 2012 The review highlights recently discovered mechanisms that sustain castration-resistant prostate cancer (CRPC) growth and describes advances in CRPC therapeutics.Recent reports have shed new light on the molecular processes underlying CRPC survival during androgen deprivation therapy (ADT).
Eric G, Bluemn, Peter S, Nelson
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Could Testosterone Have a Therapeutic Role in Prostate Cancer?
Urology Journal, 2013 PURPOSE:To discuss the role of membrane androgen receptors and to investigate the potential role of testosterone-albumin conjugate in the prostate cancer (PCa) treatment.MATERIALS AND METHODS: We identified studies published from 1990 onwards by ...
Konstantinos Stamatiou
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The Effect of Estradiol and Testosterone Levels Alone or in Combination with Their Receptors in Predicting the Severity of Systemic Lupus Erythematosus: A Cohort Study [PDF]
Iranian Journal of Medical SciencesBackground: Developing a practical method to predict active systemic lupus erythematosus (SLE) in patients with inactive/mild status at the onset of the disease could lead to appropriate treatment that ultimately prevents future relapses. The development
Samaneh Abdolahpour +4 more
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Pre-receptor regulation of the androgen receptor [PDF]
Molecular and Cellular Endocrinology, 2008 The human androgen receptor (AR) is a ligand-activated nuclear transcription factor and mediates the induction of genes involved in the development of the male phenotype and male secondary sex characteristics, as well as the normal and abnormal growth of the prostate.
Trevor M, Penning +3 more
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Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development [PDF]
, 2010 Peer ...
Richard M. Sharpe +41 more
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Androgen directs apparent cytoplasmic and nuclear distribution of rat cardiovascular androgen receptors. [PDF]
, 1985 We used either the synthetic androgen R1881 (methyltrienolone) or 5 alpha-dihydrotestosterone (5 alpha-DHT) to characterize androgen receptors in rat aortic and myocardial cytoplasmic and nuclear preparations.
A L Lin, R Gonzalez, S A Shain
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Androgen receptor epigenetics.
Translational andrology and urology, 2013 The androgen receptor (AR) is a transcription factor that drives the differentiation of prostate epithelium by regulating the expression of several hundred genes. Conversely, AR also plays a central role in prostate cancer (PCa) development, and it continues to be active in tumors that relapse after castration (castration-resistant prostate cancer ...
Cai, Changmeng +2 more
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The Androgen Receptor in Breast Cancer
Frontiers in Endocrinology, 2018 Breast cancer (BC) is a hormone-related tumor. Despite the progress in BC therapy, this disease still remains the most common cancer amongst women around the world. This is likely due to the amazing BC heterogeneity. Accumulating evidence suggests a role for androgen signaling in BC.
Giovannelli, Pia +5 more
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Evidence for a GABAergic system in rodent and human testis: Local GABA production and GABA receptors [PDF]
, 2003 The major neurotransmitter of the central nervous system, gamma-aminobutyric acid (GABA), exerts its actions through GABA(A), GABA(B) and GABA(C) receptors.
Doepner, Richard F. G. +14 more
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Expression of Androgen Receptor in Human Placentas from Normal and Preeclamptic Pregnancies
Taiwanese Journal of Obstetrics & Gynecology, 2009 Objective: To elucidate the expression of androgen receptor (AR) in human placenta from normal and preeclamptic (PE) pregnancies. Materials and Methods: This study was performed at the Division of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial ...
Te-Yao Hsu +9 more
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