Results 51 to 60 of about 78,518 (314)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Androgen Receptors in Human Breast Cancer and Female Canine Mammary Tumors

Molecules
This review explores the potential role of androgens in human breast cancer and female canine mammary tumors. Human breast cancer is one of the most common cancers affecting women globally, while female canine mammary tumors provide a natural model for ...
Vladimir Vidović, Ivana Davidov, Zoran Ružić, Mihajlo Erdeljan, Annamaria Galfi Vukomanović, Bojana Blagojević   +5 more
doaj   +1 more source

Disruption of androgen metabolism, regulation and effects : involvement of steroidogenic enzymes [PDF]

, 2014
Communication between organs and tissues is predominately controlled by hormones. Hormones regulate a vast variety of physiological and behavioural activities, including metabolism, growth and development, reproduction, sleep and mood.
Fürstenberger, Cornelia
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Proteomic changes in rat spermatogenesis in response to in vivo androgen manipulation; impact on meiotic cells. [PDF]

PLoS ONE, 2012
The production of mature sperm is reliant on androgen action within the testis, and it is well established that androgens act on receptors within the somatic Sertoli cells to stimulate male germ cell development.
Peter G Stanton, Pavel Sluka, Caroline F H Foo, Andrew N Stephens, A Ian Smith, Robert I McLachlan, Liza O'Donnell   +6 more
doaj   +1 more source

Nuclear expression of PG-21, SRC-1, and pCREB in regions of the lumbosacral spinal cord involved in pelvic innervation in young adult and aged rats

, 2012
In rats, ageing results in dysfunctional patterns of micturition and diminished sexual reflexes that may reflect degenerative changes within spinal circuitry.
Ranson, R. N., Connelly, Jennifer, Santer, Robert Murray, Watson, Alan, Ranson, Richard, Watson, Alan Hugh David, Santer, Robert, Connelly, J. H.   +7 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Early androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male rats

Reproductive Biology and Endocrinology
Gonadal steroids are involved in the organization and programming of several neural systems. The main objective of this study was to determine whether androgen activity in the early postnatal stage influenced the long-term expression of androgen and ...
Rocío García-Úbeda, Jose Manuel Fernandez-Garcia, Ulises Primo, Daniela Grassi, Antonio Ballesta, Maria Angeles Arevalo, Paloma Collado, Helena Pinos, Beatriz Carrillo   +8 more
doaj   +1 more source

ARD1/NAA10 acetylation in prostate cancer

Experimental and Molecular Medicine, 2018
Prostate cancer: Preventing androgen receptor activation Blocking the addition of an acetyl group to androgen receptors by Arrest-defect-1 protein (ARD1) might be an effective strategy for halting prostate cancer progression.
Katherine J. Kuhns, Guanyi Zhang, Zehua Wang, Wanguo Liu   +3 more
doaj   +1 more source

Leydig cell metabolic disorder act as a new mechanism affecting for focal spermatogenesis in Klinefelter syndrome patients: a real world cross-sectional study base on the age

Frontiers in Endocrinology, 2023
BackgroundKlinefelter’s syndrome (KS) was once considered infertile due to congenital chromosomal abnormalities, but the presence of focal spermatozoa changed this.
Huang Liu, Zhenhui Zhang, Yong Gao, Hai Lin, Zhiyong Zhu, Houbin Zheng, Wenjing Ye, Zefang Luo, Zhaohui Qing, Xiaolan Xiao, Lei Hu, Yu Zhou, Xinzong Zhang   +12 more
doaj   +1 more source