Results 71 to 80 of about 78,719 (215)

Prostate cancer and therapeutic challenges

Journal of Biological Research - Thessaloniki, 2020
Prostate cancer (PC) is the most prevalent type of cancer in men worldwide. In Saudi Arabia, the rate of PC is increasing annually. The sex steroid hormones androgens and their receptors have critical roles in PC development and progression. Additionally,
Yousef MohammedRabaa Hawsawi, Samar Abdullah Zailaie, Atif Abdulwahab A. Oyouni, Othman Rashed Alzahrani, Osama Mohamed Alamer, Saad Ali S. Aljohani   +5 more
doaj   +1 more source

Clinical, Hormonal and Genetics Features in patients with Androgen Insensitivity Syndrome in Cytogenetic Laboratories in Semarang [PDF]

, 2006
Androgen insensitivity syndrome (AIS) is an X-linked disorder caused by impaired Androgen Receptor (AR) which is encoded in Xq 11-12. In this condition, although the androgen is produced sufficiently, but the peripheral masculinizing effect is blocked ...
Tonang, Alvin
core  

The impact of point mutations in the human androgen receptor : classification of mutations on the basis of transcriptional activity [PDF]

, 2012
Peer ...
Iain J McEwan, Colin W. Hay (179733), McEwan, Iain J, Colin W Hay, Hay, Colin W, McEwan Iain J., Hay Colin W., Iain J. McEwan (179736)   +7 more
core   +1 more source

The Acute Responses of Different-sized Coronary Arteries to Testosterone [PDF]

, 2012
Coronary arteries supply blood to the myocardium. The blood flow within the coronary arteries is altered by various compounds produced within the body. Sex hormones such as testosterone are known to cause the relaxation of large coronary arteries.
Madanu, Sampath
core   +1 more source

Classical androgen receptors in non-classical sites in the brain [PDF]

, 2012
Androgen receptors are expressed in many different neuronal populations in the central nervous system where they often act as transcription factors in the cell nucleus.
Azcoitia, I., García-Segura, Luis M., Sarkey, Sara, García-Ovejero, D., Doncarlos, Lydia L.   +4 more
core   +1 more source

Androgens and the androgen receptor (AR)

, 2013
Introduction Androgens are sex steroid hormones that are produced in both males and females, albeit in different amounts. Androgens are essential for development and maintenance of the male phenotype (1), and are also important in females, where they can either act directly via the androgen receptor (AR) or indirectly as metabolic precursors for ...
Moore, N., Centenera, M., Butler, L., Hickey, T., Tilley, W.   +4 more
openaire   +2 more sources

A computational model of the hypothalamic - pituitary - gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone [PDF]

, 2011
© 2011 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Watanabe, Karen H, Watanabe, KH, Mitchell Kostich, Villeneuve, DL, Kostich, M, Li, Zhenhong, Zhenhong Li, Sepúlveda, MS, Jensen, Kathleen M, Villeneuve, Daniel L, Daniel L Villeneuve, María S Sepúlveda, Gerald T Ankley, Kathleen M Jensen, Ankley, GT, Nancy D Denslow, Kroll, KJ, Brandon Armstrong, James M Lazorchak, Brian, JV, Brian, Jayne V, Orlando, Edward F, Denslow, ND, Orlando, EF, Ankley, Gerald T, Armstrong, B, Lazorchak, JM, Sepulveda, Maria S, Jayne V Brian, Karen H Watanabe, Lazorchak, James M, Li, Z, Edward F Orlando, Kroll, Kevin J, Jensen, KM, Denslow, Nancy D, Kostich, Mitchell, Armstrong, Brandon, Kevin J Kroll   +38 more
core   +1 more source

Study of Validity of PC-3 Derived Xenograft Tumor Model in Athymic Nude Mice for Targeting Therapy of Androgen Receptors in Preclinical Studies of Prostate Cancer

Basic & Clinical Cancer Research, 2016
Background: Androgen receptors (AR) play an important role in proliferation of cancerous prostatic cells and prevention of apoptotic signaling. Current drugs cannot inhibit the activity of these receptors very well.
Samad Muhammadnejad, Ahad Muhammadnejad, Zohreh Mazaheri, Farrokh Tirgari, Mohammad-Ali Oghabian, Maryam Kazem haghighi, Saeid Amanpour   +6 more
doaj  

Occurrence of testicular microlithiasis in androgen insensitive hypogonadal mice [PDF]

, 2009
<b>Background</b>: Testicular microliths are calcifications found within the seminiferous tubules. In humans, testicular microlithiasis (TM) has an unknown etiology but may be significantly associated with testicular germ cell tumors ...
Margaret H Abel, Ana Monteiro, Guido Verhoeven, Abel, M.H., Verhoeven, G., De Gendt, K., Monteiro, A., Karl De Gendt, O'Shaughnessy, P.J., Peter J O'Shaughnessy   +9 more
core   +1 more source

Expression of androgen, estrogen, and progesterone hormone receptors in the penile tissues of children with different types of hypospadias

İstanbul Kuzey Klinikleri, 2019
INTRODUCTION[|]Androgen (AR), Estrogen (ER) and Progesterone (PR) hormones play an important role in the prenatal and postnatal development of urogenital tract and especially the penis.
Ayşenur Celayir, Serdar Moralıoğlu, Handan Cetiner, Gözde Kır, Sinan Celayir   +4 more
doaj   +1 more source