Results 31 to 40 of about 669,213 (305)

Androgen receptors in meningiomas [PDF]

Cancer, 1988
Meningiomas have been hypothesized as being hormonally sensitive on the basis of epidemiologic, clinical, and laboratory evidence. Eight meningiomas were assayed and found to have androgen-binding protein. Three tumors were subjected to in vitro growth studies in varying concentrations of dihydrotestosterone (DHT).
J J, Olson, D W, Beck, J W, MacIndoe, P, Min-Loh   +3 more
openaire   +2 more sources

Androgen action via testicular arteriole smooth muscle cells is important for leydig cell function, vasomotion and testicular fluid dynamics [PDF]

, 2010
Regulation of blood flow through the testicular microvasculature by vasomotion is thought to be important for normal testis function as it regulates interstitial fluid (IF) dynamics which is an important intra-testicular transport medium.
Bergh, A., Sigrid Kilter, Richard M. Sharpe, Philippa T K Saunders, Lindsey Moffat, Sharpe, R.M., Welsh Michelle, Welsh, M., Anders Bergh, Philippa T. K. Saunders, Atanassova Nina, Saunders Philippa T. K., Atanassova, N., Smith, Lee B., Richard M Sharpe, Bergh, Anders, Bergh, Anders,, Kilter Sigrid, Sharpe, Richard M, Michelle Welsh, Sharpe Richard M., Moffat Lindsey, Lee B. Smith, Sharpe, Richard M., Moffat, Lindsey, Smith, L.B., Lee B Smith, Saunders, P.T.K., Kilter, Sigrid, Bergh Anders, Saunders, Philippa T. K.; id_orcid, Welsh, Michelle, Saunders, Philippa TK, Nina Atanassova, Smith Lee B., Smith, Lee B, Moffat, L., Kilter, S., Kilter, Sigrid,, Atanassova, Nina   +39 more
core   +1 more source

Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells

Molecular Cancer, 2008
Background Recently we have reported membrane androgen receptors-induced apoptotic regression of prostate cancer cells regulated by Rho/ROCK/actin signaling.
Gravanis Achilleas, Föller Michael, Konstantinidis Georgios, Anagnostopoulou Vasileia, Charalampopoulos Ioannis, Papadopoulou Natalia, Alevizopoulos Konstantinos, Lang Florian, Stournaras Christos   +8 more
doaj   +1 more source

The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor [PDF]

, 2005
Prostate cancer is the second most common male malignancy in the western world an increasing incidence in an ageing population. Treatment of advanced prostate cancer relies on androgen deprivation.
Edwards, J., Bartlett, J.M.S.
core   +1 more source

Androgen Receptor Phosphorylation [PDF]

Endocrine Research, 1993
Phosphorylation of transcription factors plays an important role in regulation of gene expression. DNA-binding, transactivation activity, and subcellular trafficking of specific transcription factors have been shown to be regulated by phosphorylation/dephosphorylation.
L J, Blok, P E, de Ruiter, A O, Brinkmann   +2 more
openaire   +3 more sources

Spermatogenesis and sertoli cell activity in mice lacking Sertoli cell receptors for follicle stimulating hormone and androgen [PDF]

, 2008
Spermatogenesis in the adult male depends on the action of FSH and androgen. Ablation of either hormone has deleterious effects on Sertoli cell function and the progression of germ cells through spermatogenesis.
Baker, P.J., Guillou, F., Abel, M.H., Verhoeven, G., De Gendt, K., Guillou, Florian Jean Louis, Charlton, H.M., Monteiro, A., O'Shaughnessy, P.J.   +8 more
core   +1 more source

Adiponectin and its receptors in the ovary: further evidence for a link between obesity and hyperandrogenism in polycystic ovary syndrome. [PDF]

PLoS ONE, 2013
Polycystic ovary syndrome (PCOS), characterized by ovarian androgen excess, is the commonest endocrine disorder in women. Obesity increases androgen synthesis, a phenomenon attributed to the accompanying hyperinsulinemia.
Fabio V Comim, Kate Hardy, Stephen Franks   +2 more
doaj   +1 more source

Masculinizing hormone therapy effect on breast tissue: Changes in estrogen and androgen receptors in transgender female-to-male mastectomies

Breast, 2023
Purpose: Almost two percent of individuals in the United States identify as gender non-conforming. In the female-to-male (FTM) transgender population, masculinizing hormone therapy with testosterone is commonly prescribed in gender transition.
Manita Chaum, Sara Grossi, Jiaxi Chen, Vivian Hu, Edward Ray, Armando Giuliano, Shikha Bose   +6 more
doaj   +1 more source

Nuclear expression of PG-21, SRC-1, and pCREB in regions of the lumbosacral spinal cord involved in pelvic innervation in young adult and aged rats [PDF]

, 2012
In rats, ageing results in dysfunctional patterns of micturition and diminished sexual reflexes that may reflect degenerative changes within spinal circuitry.
Ranson, R. N., Connelly, Jennifer, Santer, Robert Murray, Watson, Alan, Ranson, Richard, Watson, Alan Hugh David, Santer, Robert, Connelly, J. H.   +7 more
core   +1 more source

The multiple actions of testosterone in men: nature knows best

Asian Journal of Andrology, 2014
In male hormone replacement therapy Finkelstein et al. show that testosterone rather than synthetic "pure" androgens should be prescribed. Testosterone is converted to the superactive androgen dihydrotestosterone and to estradiol, and thus has actions ...
John W Funder
doaj   +1 more source