Results 21 to 30 of about 78,518 (314)

Immunohistochemical features of ovarian structure at polycystic ovary syndrom depending on the age

Patologìâ, 2012
peculiarities of proliferation factors and androgens receptors expression in women with PCOS, depending on age were analyzed. It was revealed that pronounced expression of PCNA, cytokeratin and androgen receptors in stroma and intengification of PCNA ...
I. Yu. Ganzhiy
doaj   +1 more source

The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor [PDF]

, 2005
Prostate cancer is the second most common male malignancy in the western world an increasing incidence in an ageing population. Treatment of advanced prostate cancer relies on androgen deprivation.
Edwards, J., Bartlett, J.M.S.
core   +1 more source

Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells

Molecular Cancer, 2008
Background Recently we have reported membrane androgen receptors-induced apoptotic regression of prostate cancer cells regulated by Rho/ROCK/actin signaling.
Gravanis Achilleas, Föller Michael, Konstantinidis Georgios, Anagnostopoulou Vasileia, Charalampopoulos Ioannis, Papadopoulou Natalia, Alevizopoulos Konstantinos, Lang Florian, Stournaras Christos   +8 more
doaj   +1 more source

Androgen Receptor and Mechanism of Androgen Action

Annals of Medicine, 1993
Androgen receptor is the intracellular protein that mediates biological actions of physiological androgens (testosterone and 5 alpha-dihydrotestosterone). Androgen receptor belongs to a large family of ligand-dependent proteins whose function is to modulate expression of genes and gene networks in a cell- and tissue-specific manner.
O A, Jänne, J J, Palvimo, P, Kallio, M, Mehto   +3 more
openaire   +2 more sources

Androgen receptor abnormalities [PDF]

The Journal of Steroid Biochemistry and Molecular Biology, 1991
The human androgen receptor is a member of the superfamily of steroid hormone receptors. Proper functioning of this protein is a prerequisite for normal male sexual differentiation and development. The cloning of the human androgen receptor cDNA and the elucidation of the genomic organization of the corresponding gene has enabled us to study androgen ...
Brinkmann, A. O., Kuiper, G. G., Ris-Stalpers, C., van Rooij, H. C., Romalo, G., Trifiro, M., Mulder, E., Pinsky, L., Schweikert, H. U., Trapman, J.   +9 more
openaire   +2 more sources

Spermatogenesis and sertoli cell activity in mice lacking Sertoli cell receptors for follicle stimulating hormone and androgen [PDF]

, 2008
Spermatogenesis in the adult male depends on the action of FSH and androgen. Ablation of either hormone has deleterious effects on Sertoli cell function and the progression of germ cells through spermatogenesis.
Baker, P.J., Guillou, F., Abel, M.H., Verhoeven, G., De Gendt, K., Guillou, Florian Jean Louis, Charlton, H.M., Monteiro, A., O'Shaughnessy, P.J.   +8 more
core   +1 more source

Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen. [PDF]

, 1993
Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone receptor superfamily. In this work the effect of androgens and antiandrogens on the expression of the human androgen receptor (hAR) in prostate and breast ...
Herzinger, Thomas, Blasschke, Dorothea, Hermeking, H., Hörz, W., Herzinger, T., Blaschke, D., Hörz, Wolfram, Wolf, Dieter A., Hermeking, Heiko, Wolf, D.A.   +9 more
core   +1 more source

Masculinizing hormone therapy effect on breast tissue: Changes in estrogen and androgen receptors in transgender female-to-male mastectomies

Breast, 2023
Purpose: Almost two percent of individuals in the United States identify as gender non-conforming. In the female-to-male (FTM) transgender population, masculinizing hormone therapy with testosterone is commonly prescribed in gender transition.
Manita Chaum, Sara Grossi, Jiaxi Chen, Vivian Hu, Edward Ray, Armando Giuliano, Shikha Bose   +6 more
doaj   +1 more source

The multiple actions of testosterone in men: nature knows best

Asian Journal of Andrology, 2014
In male hormone replacement therapy Finkelstein et al. show that testosterone rather than synthetic "pure" androgens should be prescribed. Testosterone is converted to the superactive androgen dihydrotestosterone and to estradiol, and thus has actions ...
John W Funder
doaj   +1 more source

Adiponectin and its receptors in the ovary: further evidence for a link between obesity and hyperandrogenism in polycystic ovary syndrome. [PDF]

PLoS ONE, 2013
Polycystic ovary syndrome (PCOS), characterized by ovarian androgen excess, is the commonest endocrine disorder in women. Obesity increases androgen synthesis, a phenomenon attributed to the accompanying hyperinsulinemia.
Fabio V Comim, Kate Hardy, Stephen Franks   +2 more
doaj   +1 more source