Results 11 to 20 of about 78,518 (314)

Androgen Receptor Phosphorylation [PDF]

Endocrine Research, 1993
Phosphorylation of transcription factors plays an important role in regulation of gene expression. DNA-binding, transactivation activity, and subcellular trafficking of specific transcription factors have been shown to be regulated by phosphorylation/dephosphorylation.
L J, Blok, P E, de Ruiter, A O, Brinkmann   +2 more
openaire   +3 more sources

Membrane testosterone binding sites in prostate carcinoma as a potential new marker and therapeutic target: Study in paraffin tissue sections

BMC Cancer, 2005
Background Steroid action is mediated, in addition to classical intracellular receptors, by recently identified membrane sites, that generate rapid non-genomic effects.
Theodoropoulos Panayiotis A, Anezinis Ploutarchos, Nomikos Michael, Darivianaki Katherine, Kampa Marilena, Kogia Christina, Dambaki Constantina, Castanas Elias, Stathopoulos Efstathios N   +8 more
doaj   +1 more source

Partial Androgen Insensitivity Syndrome Presenting with Gynecomastia [PDF]

Endocrinology and Metabolism, 2015
Gynecomastia is a benign enlargement of the male breast caused by the proliferation of glandular breast tissue. Determining the various causes of gynecomastia such as physiological causes, drugs, systemic diseases, and endocrine disorders is important ...
Sung Won Lee, Dong Shin Kwak, In Sub Jung, Joo Hee Kwak, Jung Hwan Park, Sang Mo Hong, Chang Bum Lee, Yong Soo Park, Dong Sun Kim, Woong Hwan Choi, You Hern Ahn   +10 more
doaj   +1 more source

Direct action through the Sertoli cells is essential for androgen stimulation of spermatogenesis [PDF]

, 2010
Androgens act to stimulate spermatogenesis through androgen receptors (AR) on the Sertoli cells and peritubular myoid cells (PTM). Specific ablation of the AR in either cell type will cause a severe disruption of spermatogenesis.
Abel, M.H., Verhoeven, G., De Gendt, K., Monteiro, A., O'Shaughnessy, P.J.   +4 more
core   +1 more source

Immunohistochemical expression of androgen receptors in prostate carcinoma and benign prostatic hyperplasia [PDF]

Vojnosanitetski Pregled, 2020
Background/Aim. Prostate carcinoma (PCa) and its parent organ are influenced by hormones, which is used for therapeutic purposes. Through androgen receptors (AR) androgens influence cell growth and function, proliferation, differentiation, apoptosis ...
Trivunić-Dajko Sandra, Bogdanović Jovo, Fejsa-Levakov Aleksandra, Živojinov Mirjana, Đolai Matilda   +4 more
doaj   +1 more source

Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors [PDF]

, 2010
Follicle stimulating hormone (FSH) and androgen act to stimulate and maintain spermatogenesis. FSH acts directly on the Sertoli cells to stimulate germ cell number and acts indirectly to increase androgen production by the Leydig cells.
Abel, M.H., Verhoeven, G., De Gendt, K., Monteiro, A., O'Shaughnessy, P.J.   +4 more
core   +1 more source

A computational insight into endocrine disruption by polychlorinated biphenyls via non-covalent interactions with human nuclear receptors

Ecotoxicology and Environmental Safety, 2021
Production of polychlorinated biphenyls (PCBs) was banned a long time ago because of their harmful health effects but humans continue to be exposed to residual PCBs in the environment.
Lukman K. Akinola, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi   +3 more
doaj   +1 more source

Androgen receptors in meningiomas [PDF]

Cancer, 1988
Meningiomas have been hypothesized as being hormonally sensitive on the basis of epidemiologic, clinical, and laboratory evidence. Eight meningiomas were assayed and found to have androgen-binding protein. Three tumors were subjected to in vitro growth studies in varying concentrations of dihydrotestosterone (DHT).
J J, Olson, D W, Beck, J W, MacIndoe, P, Min-Loh   +3 more
openaire   +2 more sources

The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 2: androgen-receptor cofactors and bypass pathways [PDF]

, 2005
Prostate cancer is the second leading cause of cancer related deaths in men from the western world. Treatment of prostate cancer has relied on androgen deprivation therapy for the past 50 years.
J Edwards, Edwards, J., Bartlett, J.M.S., J. M. S. Bartlett   +3 more
core   +1 more source

Androgen action via testicular arteriole smooth muscle cells is important for leydig cell function, vasomotion and testicular fluid dynamics [PDF]

, 2010
Regulation of blood flow through the testicular microvasculature by vasomotion is thought to be important for normal testis function as it regulates interstitial fluid (IF) dynamics which is an important intra-testicular transport medium.
Bergh, A., Sigrid Kilter, Richard M. Sharpe, Philippa T K Saunders, Lindsey Moffat, Sharpe, R.M., Welsh Michelle, Welsh, M., Anders Bergh, Philippa T. K. Saunders, Atanassova Nina, Saunders Philippa T. K., Atanassova, N., Smith, Lee B., Richard M Sharpe, Bergh, Anders, Bergh, Anders,, Kilter Sigrid, Sharpe, Richard M, Michelle Welsh, Sharpe Richard M., Moffat Lindsey, Lee B. Smith, Sharpe, Richard M., Moffat, Lindsey, Smith, L.B., Lee B Smith, Saunders, P.T.K., Kilter, Sigrid, Bergh Anders, Saunders, Philippa T. K.; id_orcid, Welsh, Michelle, Saunders, Philippa TK, Nina Atanassova, Smith Lee B., Smith, Lee B, Moffat, L., Kilter, S., Kilter, Sigrid,, Atanassova, Nina   +39 more
core   +1 more source