Testicular development in mice lacking receptors for follicle stimulating hormone and androgen. [PDF]
PLoS ONE, 2012 Post-natal testicular development is dependent on gonadotrophin and androgen stimulation. Follicle stimulating hormone (FSH) acts through receptors (FSHR) on the Sertoli cell to stimulate spermatogenesis while androgens promote testis growth through ...
Peter J O'Shaughnessy +2 more
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Overexpression of Androgen, Oestrogen and Progesterone Receptors in Skin Lesions of Becker’s Naevus [PDF]
Acta Dermato-Venereologica, 2018 Becker’s naevus is androgen-dependent. The aim of this study was to investigate whether oestrogen and progesterone receptors are involved in this disorder.
Ping Sheng +6 more
doaj +2 more sources
Androgens and Androgen Receptor Actions on Bone Health and Disease: From Androgen Deficiency to Androgen Therapy [PDF]
Cells, 2019 Androgens are not only essential for bone development but for the maintenance of bone mass. Therefore, conditions with androgen deficiency, such as male hypogonadism, androgen-insensitive syndromes, and prostate cancer with androgen deprivation therapy ...
Jia-Feng Chen +4 more
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Direct action through the Sertoli cells is essential for androgen stimulation of spermatogenesis [PDF]
, 2010 Androgens act to stimulate spermatogenesis through androgen receptors (AR) on the Sertoli cells and peritubular myoid cells (PTM). Specific ablation of the AR in either cell type will cause a severe disruption of spermatogenesis.
Abel, M.H. +4 more
core +1 more source
Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors [PDF]
, 2010 Follicle stimulating hormone (FSH) and androgen act to stimulate and maintain spermatogenesis. FSH acts directly on the Sertoli cells to stimulate germ cell number and acts indirectly to increase androgen production by the Leydig cells.
Abel, M.H. +4 more
core +1 more source
Androgen Receptor Phosphorylation [PDF]
Endocrine Research, 1993 Phosphorylation of transcription factors plays an important role in regulation of gene expression. DNA-binding, transactivation activity, and subcellular trafficking of specific transcription factors have been shown to be regulated by phosphorylation/dephosphorylation.
L J, Blok +2 more
openaire +3 more sources
Androgen receptors in meningiomas [PDF]
Cancer, 1988 Meningiomas have been hypothesized as being hormonally sensitive on the basis of epidemiologic, clinical, and laboratory evidence. Eight meningiomas were assayed and found to have androgen-binding protein. Three tumors were subjected to in vitro growth studies in varying concentrations of dihydrotestosterone (DHT).
J J, Olson +3 more
openaire +2 more sources
The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 2: androgen-receptor cofactors and bypass pathways [PDF]
, 2005 Prostate cancer is the second leading cause of cancer related deaths in men from the western world. Treatment of prostate cancer has relied on androgen deprivation therapy for the past 50 years.
J Edwards +3 more
core +1 more source
Androgen action via testicular arteriole smooth muscle cells is important for leydig cell function, vasomotion and testicular fluid dynamics [PDF]
, 2010 Regulation of blood flow through the testicular microvasculature by vasomotion is thought to be important for normal testis function as it regulates interstitial fluid (IF) dynamics which is an important intra-testicular transport medium.
Bergh, A. +39 more
core +1 more source
Immunohistochemical features of ovarian structure at polycystic ovary syndrom depending on the age
Patologìâ, 2012 peculiarities of proliferation factors and androgens receptors expression in women with PCOS, depending on age were analyzed. It was revealed that pronounced expression of PCNA, cytokeratin and androgen receptors in stroma and intengification of PCNA ...
I. Yu. Ganzhiy
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