Results 21 to 30 of about 106,627 (314)

The local hormonal environment of tumor and perifocal zone in patients with breast cancer: data and prospects of their application

Опухоли женской репродуктивной системы, 2016
The expression of androgen receptors is maximal in the luminal subtypes of breast cancer (BC) and increases with patient age, except triplenegative cancer cases.
Yu. S. Shatova, E. M. Frantsiyants, I. A. Novikova, L. N. Vashchenko, V. A. Bandovkina, M. I. Vereskunova, A. N. Khugaeva, V. V. Tokmakov   +7 more
doaj   +1 more source

Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells

Molecular Cancer, 2008
Background Recently we have reported membrane androgen receptors-induced apoptotic regression of prostate cancer cells regulated by Rho/ROCK/actin signaling.
Gravanis Achilleas, Föller Michael, Konstantinidis Georgios, Anagnostopoulou Vasileia, Charalampopoulos Ioannis, Papadopoulou Natalia, Alevizopoulos Konstantinos, Lang Florian, Stournaras Christos   +8 more
doaj   +1 more source

The effect of different types of hepatic injury on the estrogen and androgen receptor activity of liver [PDF]

, 1989
Mammalian liver contains receptors for both estrogens and androgens. Hepatic regeneration after partial hepatectomy in male rats is associated with a loss of certain male-specific hepatic characteristics.
Aten R. F., Bannister P., Bardin C. W., Booth A. N., Cardon S. B., Chamness G. C., D. H. Van Thiel, D. Kahn, Eagon P. K., Eisenfeld A. J., Farrell G. C., Francavilla A., Francavilla A., Gustafsson J. A., H. Lai, Higgins E. M., L. Makowka, Lowry O. H., M. Kajani, P. K. Eagon, Q. Zeng, Starzl T. E., T. E. Starzl, Van DH Thiel, Van DH Thiel   +24 more
core   +1 more source

Androgen receptor mutations [PDF]

The Journal of Steroid Biochemistry and Molecular Biology, 1995
Male sexual differentiation and development proceed under direct control of androgens. Androgen action is mediated by the intracellular androgen receptor, which belongs to the superfamily of ligand-dependent transcription factors. At least three pathological situations are associated with abnormal androgen receptor structure and function: androgen ...
C. Ris-Stalpers, Annemie L.M. Boehmer, J.A.G.M. van der Korput, Albert O. Brinkmann, Jan Trapman, Hennie T. Brüggenwirth, Guido Jenster   +6 more
openaire   +2 more sources

DRUG THERAPY FOR ANDROGEN-POSITIVE BREAST CANCER

Сибирский онкологический журнал, 2021
There are some types of breast cancer (BC) that depend on their molecular characteristics. However, lately researchers provide date regarding the presence of additional receptors of triple negative breast cancer (TNBC).
A. D. Zikiryakhodjhaev, A. A. Fedenko, M. V. Starkova, V. S. Surkova, M. V. Sedova   +4 more
doaj   +1 more source

Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice [PDF]

, 2009
Development and maintenance of the male phenotype and establishment of fertility are all dependent upon the activity of the Sertoli cells and Leydig cells of the testis.
Abel, M.H., Baker, P.J., Huhtaniemi, I., Morris, I.D., O'Shaughnessy, P.J.   +4 more
core   +1 more source

Regulatory effect of gut microbes on blood pressure

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 513-531, December 2022., 2022
The interaction between gut microbiota and hypertension, the genera which affect the blood pressure in taxonomic level, and the commonly used treatments to hypertension based on the gut microbes were summarized in this review. The increases of Lactobacillus, etc.
Dong Yan, Ye Sun, Xiaoyue Zhou, Wenhao Si, Jieyu Liu, Min Li, Minna Wu   +6 more
wiley   +1 more source

Androgen receptor abnormalities [PDF]

The Journal of Steroid Biochemistry and Molecular Biology, 1991
The human androgen receptor is a member of the superfamily of steroid hormone receptors. Proper functioning of this protein is a prerequisite for normal male sexual differentiation and development. The cloning of the human androgen receptor cDNA and the elucidation of the genomic organization of the corresponding gene has enabled us to study androgen ...
George G. J. M. Kuiper, Albert O. Brinkmann, H.U. Schweikert, H. C. J. Van Rooij, Jan Trapman, Gabriela Romalo, Leonard Pinsky, Mark Trifiro, Eppo Mulder, C. Ris-Stalpers   +9 more
openaire   +3 more sources

The multiple actions of testosterone in men: nature knows best

Asian Journal of Andrology, 2014
In male hormone replacement therapy Finkelstein et al. show that testosterone rather than synthetic "pure" androgens should be prescribed. Testosterone is converted to the superactive androgen dihydrotestosterone and to estradiol, and thus has actions ...
John W Funder
doaj   +1 more source

Revising Berg-Purcell for finite receptor kinetics [PDF]

, 2021
From nutrient uptake, to chemoreception, to synaptic transmission, many systems in cell biology depend on molecules diffusing and binding to membrane receptors. Mathematical analysis of such systems often neglects the fact that receptors process molecules at finite kinetic rates.
arxiv   +1 more source