Results 51 to 60 of about 2,509,684 (324)

Androgenetic alopecia: a review [PDF]

, 2017
Purpose Androgenetic alopecia, commonly known as male pattern baldness, is the most common type of progressive hair loss disorder in men. The aim of this paper is to review recent advances in understanding the pathophysiology and molecular mechanism
Caro, Gemma, Fortuna, MARIA CATERINA, Lenzi, Andrea, Lolli, Francesca, Lombardo, Francesco, Pallotti, Francesco, Rossi, Alfredo, Sansone, Andrea   +7 more
core   +1 more source

Androgens and Androgen Receptor Actions on Bone Health and Disease: From Androgen Deficiency to Androgen Therapy

Cells, 2019
Androgens are not only essential for bone development but for the maintenance of bone mass. Therefore, conditions with androgen deficiency, such as male hypogonadism, androgen-insensitive syndromes, and prostate cancer with androgen deprivation therapy ...
Jia-Feng Chen, Pei-Wen Lin, Yi-Ru Tsai, Yi-Chien Yang, Hong-Yo Kang   +4 more
semanticscholar   +1 more source

A study of the prostate, androgens and sexual activity of male rats

Reproductive Biology and Endocrinology, 2007
Background The prostate is a sexual gland that produces important substances for the potency of sperm to fertilize eggs within the female reproductive tract, and is under complex endocrine control.
Garcia Luis I, Rojas Fausto, Díaz Rosaura, Aranda-Abreu Gonzalo E, Soto-Cid Abraham, Hernandez Maria, Toledo Rebeca, Manzo Jorge   +7 more
doaj   +1 more source

Contribution of recent transgenic models and transcriptional profiling studies to our understanding of the mechanisms by which androgens control spermatogenesis [PDF]

, 2008
Publisher ...
Claessens, Frank, De Gendt, Karel, Denolet, Evi, Saunders, Philippa T K, Sharpe, Richard, Swinnen, Johannes V, Verhoeven, Guido, Willems, Ariane   +7 more
core   +1 more source

Structure of the homodimeric androgen receptor ligand-binding domain

Nature Communications, 2017
The androgen receptor (AR) plays a crucial role in normal physiology, development and metabolism as well as in the aetiology and treatment of diverse pathologies such as androgen insensitivity syndromes (AIS), male infertility and prostate cancer (PCa ...
M. Nadal, S. Prekovic, Nerea Gallastegui, C. Helsen, M. Abella, K. Zielinska, M. Gay, M. Vilaseca, M. Taulés, A. Houtsmuller, M. V. van Royen, F. Claessens, P. Fuentes-Prior, E. Estébanez-Perpiñá   +13 more
semanticscholar   +1 more source

Testosterone Influence on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome [PDF]

, 2019
Purpose: Sjögren syndrome is an autoimmune disorder that occurs almost exclusively in women and is associated with extensive inflammation in lacrimal tissue, an immune-mediated destruction and/or dysfunction of glandular epithelial cells, and a ...
Kam, Wendy R., Lieberman, Scott M., Morthen, Mathias Kaurstad, Rahimi Darabad, Raheleh, Richards, Stephen M., Sullivan, David A., Tellefsen, Sara   +6 more
core   +2 more sources

Integrins and Actions of Androgen in Breast Cancer

Cells, 2023
Androgen has been shown to regulate male physiological activities and cancer proliferation. It is used to antagonize estrogen-induced proliferative effects in breast cancer cells. However, evidence indicates that androgen can stimulate cancer cell growth
Chung-Che Tsai, Yu-Chen S. H. Yang, Yi-Fong Chen, Lin-Yi Huang, Yung-Ning Yang, Sheng-Yang Lee, Wen-Long Wang, Hsin-Lun Lee, Jacqueline Whang-Peng, Hung-Yun Lin, Kuan Wang   +10 more
doaj   +1 more source

Testosterone affects song modulation during simulated territorial intrusions in male black redstarts (Phoenicurus ochruros) [PDF]

, 2012
Although it has been suggested that testosterone plays an important role in resource allocation for competitive behavior, details of the interplay between testosterone, territorial aggression and signal plasticity are largely unknown.
Apfelbeck, Beate, Bartell, Paul A., Goymann, Wolfgang, Kiefer, Sarah, Kipper, Silke, Mortega, Kim G.   +5 more
core   +12 more sources

Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications [PDF]

, 2017
The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase.
Ahmed, S. Faisal, Alves-Lopes, Rheure, Lucas-Herald, Angela K., Montezano, Augusto C., Touyz, Rhian M.   +4 more
core   +1 more source

Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway

Frontiers in Pharmacology
BackgroundPulmonary arterial hypertension (PAH) exhibits significant gender differences in prognosis, with male patients typically showing worse outcomes than females.
Jiayan Sun, Jiayan Sun, Jiayan Sun, Jiancheng Lin, Jiancheng Lin, Jiancheng Lin, Di Yin, Di Yin, Di Yin, Zetao Pan, Zetao Pan, Zetao Pan, Yuheng Ye, Yuheng Ye, Yuheng Ye, Yi Wang, Yi Wang, Yi Wang, Xiaowan Wang, Xiaowan Wang, Xiaowan Wang, Qiang Guo, Qiang Guo, Qiang Guo, Qiang Guo   +24 more
doaj   +1 more source