Results 91 to 100 of about 2,530,199 (377)
Journal of Biological Chemistry, 1995 Angiotensin II acts on at least two distinct receptor subtypes (AT1 and AT2). Most known effects of angiotensin II in adult tissues are attributable to the AT1 receptor.
Masashi Mukoyama +7 more
semanticscholar +1 more source
Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications [PDF]
, 2016 Aging is the primary risk factor underlying hypertension and incident cardiovascular disease. With aging, the vasculature undergoes structural and functional changes characterized by endothelial dysfunction, wall thickening, reduced distensibility, and ...
Harvey, Adam +4 more
core +1 more source
Advanced Science, EarlyView.NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao +13 more
wiley +1 more source
Many Faces of Renin-angiotensin System - Focus on Eye
Open Ophthalmology Journal, 2017 The renin-angiotensin system (RAS), that is known for its role in the regulation of blood pressure as well as in fluid and electrolyte homeostasis, comprises dozens of angiotensin peptides and peptidases and at least six receptors. Six central components
M. Holappa, H. Vapaatalo, A. Vaajanen
semanticscholar +1 more source
Molecular determinants of acute kidney injury [PDF]
, 2015 BACKGROUND: Acute kidney injury (AKI) is a condition that leads to a rapid deterioration of renal function associated with impairment to maintain electrolyte and acid balance, and, if left untreated, ultimately irreversible kidney damage and renal ...
Human, Christin, Husi, Holger
core +2 more sources
Angiotensin Receptors, Autoimmunity, and Preeclampsia [PDF]
The Journal of Immunology, 2007 Abstract Preeclampsia is a pregnancy-induced hypertensive disorder that causes substantial maternal and fetal morbidity and mortality. Despite being a leading cause of maternal death and a major contributor to maternal and perinatal morbidity, the mechanisms responsible for the pathogenesis of preeclampsia are poorly understood.
Rodney E. Kellems +3 more
openaire +3 more sources
Advanced Science, EarlyView.Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang +4 more
wiley +1 more source
Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease
Clinical and Experimental Hypertension, 2018 Renin angiotensin system (RAS) is an endogenous hormone system involved in the control of blood pressure and fluid volume. Dysregulation of RAS has a pathological role in causing cardiovascular diseases through hypertension.
Misbah Hussain, Fazli Rabbi Awan
doaj +1 more source
A hydrophobic-interaction-based mechanism trigger docking between the SARS CoV 2 spike and angiotensin-converting enzyme 2 [PDF]
arXiv, 2020 A recent experimental study found that the binding affinity between the cellular receptor human angiotensin converting enzyme 2 (ACE2) and receptor-binding domain (RBD) in spike (S) protein of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is more than 10-fold higher than that of the original severe acute respiratory syndrome ...
arxiv
Immunologic Effects of the Renin-Angiotensin System.
Journal of the American Society of Nephrology, 2017 Inappropriate activation of the renin-angiotensin system (RAS) exacerbates renal and vascular injury. Accordingly, treatment with global RAS antagonists attenuates cardiovascular risk and slows the progression of proteinuric kidney disease.
S. Crowley, Nathan P. Rudemiller
semanticscholar +1 more source