Results 101 to 110 of about 2,530,199 (377)

Differential involvement of hippocampal angiotensin 1 receptors in learning and memory processes in bulbectomized rats [PDF]

, 2016
There is conflicting evidence regarding the effect of AT1 receptor antagonists on learning and memory processes. The effects of angiotensin II and losartan administration into CA1 hippocampal area on the avoidance performance in olfactory bulbectomized ...
Belcheva, Iren, Belcheva, Stiliana, Ivanova, Margarita, Tashev, Roman   +3 more
core   +1 more source

Neuro-hormonal effects of physical activity in the elderly. [PDF]

, 2013
Thanks to diagnostic and therapeutic advances, the elderly population is continuously increasing in the western countries. Accordingly, the prevalence of most chronic age-related diseases will increase considerably in the next decades, thus it will be ...
Allocca, E, Bonaduce, D, D'Amico, L, de Lucia, C, Femminella, GD, Ferrara, N, Formisano, R, Iacotucci, P, Pagano, G, Petraglia, L, Ratto, E, Rengo, C, Rengo, G   +12 more
core   +1 more source

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan, Li Shu, Yidan Zheng, Yidong Wang, Mengsha Zheng, Jie Sun, Jiantao Fu, Zihao Zhou, Shen Song, Zhenjie Liu, Fei Li, Zhejun Cai   +11 more
wiley   +1 more source

From the choice of antihypertensive drug to the choice of fixed combinations of antihypertensive drugs: a paradigm shift [PDF]

Системные гипертензии, 2015
The article considers modern approaches to treatment of arterial hypertension. Emphasizes the need for combination antihypertensive therapy, mainly fixed combinations of antihypertensive drugs, patients with high and very high risk already at the start ...
O D Ostroumova, O V Bondarets, I I Kopchenov, T F Guseva   +3 more
doaj  

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with COVID-19: General Considerations and Clinical Implications

Journal of Cardiac Arrhythmias, 2020
Initially reported in China at the end of 2019, the coronavirus pandemic has now reached an international scale with more than1.5 million cases worldwide and more than 80,000 deaths by April 8th of this year.
Neiberg de Alcantara Lima, Pedro Yuri Paiva Lima, Ricardo Lessa de Castro Junior, Eric Martin Sieloff, Stela Maria Vitorino Sampaio   +4 more
doaj   +1 more source

Quantum Optical Immunoassay: Upconversion Nanoparticle-based Neutralizing Assay for COVID-19 [PDF]

arXiv, 2021
In a viral pandemic, a few important tests are required for successful containment of the virus and reduction in severity of the infection. Among those tests, a test for the neutralizing ability of an antibody is crucial for assessment of population immunity gained through vaccination, and to test therapeutic value of antibodies made to counter the ...
arxiv  

Independent β-Arrestin2 and Gq/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor

Journal of Biological Chemistry, 2009
Recent studies in receptor-transfected cell lines have demonstrated that extracellular signal-regulated kinase (ERK) activation by angiotensin type 1A receptor and other G protein-coupled receptors can be mediated by both G protein-dependent and β ...
Jihee Kim, Seungkirl Ahn, K. Rajagopal, R. Lefkowitz   +3 more
semanticscholar   +1 more source

The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans [PDF]

, 2012
Aims - Inhibition of neutral endopeptidases (NEP) results in a beneficial increase in plasma concentrations of natriuretic peptides such as ANP.
Alison Seed, Ando, Anthony P. Davenport, Battistini, Bayes, Bucchwalder-Csajka, Chen, Christopher Hillier, D'Orleans-Juste, Davenport, Davenport, Davenport, Dhaun, Dickstein, Dive, Emoto, Favrat, Fecteau, Ferro, Fiona Johnston, Flather, Garg, Hand, Hanka J. de Voogd, Hans Essers, Haynes, Haynes, Janet J. Maguire, Jardine, John McMurray, Johnstrom, Kentsch, Ling, Love, Maguire, Maguire, Maguire, McDonagh, McDowell, Naruse, Newby, Northridge, Northridge, O'Connell, Palmer, Plumpton, Rhoda E. Kuc, Richards, Richards, Richards, Rousso, Russell, Russell, Russell, Russell, Schirger, Tabrizchi, Thöne-Reinke, Vachiéry, Van der Meer, Xu, Yanagisawa, Yusuf   +62 more
core   +2 more sources

Signaling pathways linking behavior to neurogenesis in healthy brain and disease [PDF]

, 2020
Self-repair of the adult brain is limited – most diseases lack effective therapy. In order to better understand how a regenerative response can be achieved, studying mechanisms shaping the neurogenic niche, from environmental factors to intrinsic ...
Klempin, Friederike
core   +1 more source

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

Advanced Science, EarlyView.
Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen, Dongwei Liu, Lei Lei, Ting Liu, Shaokang Pan, Hui Wang, Yong Liu, Yingjin Qiao, Zhangsuo Liu, Qi Feng   +9 more
wiley   +1 more source