Results 31 to 40 of about 2,530,199 (377)
Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications
Journal of Cell Signaling, 2016 Angiotensinogen – a serpin family protein predominantly produced by the liver is systematically processed by proteases of the Renin Angiotensin system (RAS) generating hormone peptides.
K. D. Singh, S. Karnik
semanticscholar +1 more source
Tetracycline as an inhibitor to the coronavirus SARS-CoV-2 [PDF]
J Cell Biochem (2021) 1-8, 2020 The coronavirus SARS-CoV-2 remains an extant threat against public health on a global scale. Cell infection begins when the spike protein of SARS-CoV-2 binds with the cell receptor, angiotensin-converting enzyme 2 (ACE2). Here, we address the role of Tetracycline as an inhibitor for the receptor-binding domain (RBD) of the spike protein.
arxiv +1 more source
Pharmacological effects of raas blockade in ischemic nephropathy [PDF]
, 2016 Background: The management of ischemic nephropathy due to atherosclerotic renal artery stenosis has become increasingly conservative in the modern era, with current guidelines recommending optimized medical therapy as the initial step.
Barbano, Biagio +8 more
core +1 more source
Angiotensin peptides in the regulation of adrenal cortical function
Exploration of Medicine, 2021 The adrenal cortex plays a key role in the regulation of metabolism, salt and water homeostasis and sex differentiation by synthesizing glucocorticoid, mineralocorticoid and androgen hormones.
Gian Paolo Rossi +4 more
doaj +1 more source
Drug treatment of hypertension: focus on vascular health [PDF]
, 2016 Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C. +2 more
core +1 more source
Receptor Interactions of Angiotensin II and Angiotensin Receptor Blockers—Relevance to COVID-19 [PDF]
Biomolecules, 2021 Angiotensin II (Ang II) may contain a charge relay system (CRS) involving Tyr/His/carboxylate, which creates a tyrosinate anion for receptor activation. Energy calculations were carried out to determine the preferred geometry for the CRS in the presence and absence of the Arg guanidino group occupying position 2 of Ang II.
John Matsoukas +8 more
openaire +4 more sources
Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms [PDF]
St-Pierre D, et al. (2018), Biochem Pharmacol. 154:104-17, 2019 G protein coupled receptors (GPCRs) produce pleiotropic effects by their capacity to engage numerous signaling pathways once activated. Functional selectivity (also called biased signaling), where specific compounds can bring GPCRs to adopt conformations that enable selective receptor coupling to distinct signaling pathways, continues to be ...
arxiv +1 more source
Emerging pharmacological treatments to prevent abdominal aortic aneurysm growth and rupture [PDF]
, 2015 Abdominal aortic aneurysm (AAA) is a local expansion of the abdominal aorta wall caused by a complex multifactorial maladaptive vascular remodeling. Despite recent advances in the management of cardiovascular diseases, there currently is no established ...
Fraga-Silva, Rodrigo +2 more
core +2 more sources
Temporal profile and mechanisms of the prompt sympathoexcitation following coronary ligation in Wistar rats [PDF]
, 2014 Our aim was to assess the timing and mechanisms of the sympathoexcitation that occurs immediately after coronary ligation. We recorded thoracic sympathetic (tSNA) and phrenic activities, heart rate (HR) and perfusion pressure in Wistar rats subjected to ...
Abdala, Ana Paula +5 more
core +11 more sources
PLoS ONE, 2013 The renin-angiotensin system is involved in multiple conditions ranging from cardiovascular disorders to cancer. Components of the pathway, including ACE, renin and angiotensin receptors are targets for disease treatment.
Jeremy W Prokop +2 more
doaj +1 more source