Folia Histochemica et Cytobiologica, 2011 Angiotensin II (AngII) is the biologically active peptide of the renin-angiotensin system (RAS). Tissue- based, local RAS has been identified in the prostate, testis, epididymis and coagulating glands.
Kamila Domińska +5 more
doaj +1 more source
Angiotensin type-2 (AT-2)-receptor activation reduces renal fibrosis in cyclosporine nephropathy: evidence for blood-pressure independent effect [PDF]
, 2016 Compound 21 (C21), selective agonist of AT2 receptors, shows antinflammatory effects in hypertension and nephroprotection in diabetes. The aim of this study was to evaluate the effects of C21 in cyclosporine nephropathy, which is characterized mainly by ...
Carletti, R +5 more
core +1 more source
The actions of Pasteurella multocida toxin on neuronal cells [PDF]
, 2014 Pasteurella multocida toxin (PMT) activates the G-proteins Gα, Gα, Gα Gα and Gα by deamidation of specific glutamine residues. A number of these alpha subunits have signalling roles in neurones.
Duricki, DA +4 more
core +1 more source
ISN Forefronts Symposium 2015: Nuclear Receptors and Diabetic Nephropathy
Kidney International Reports, 2016 Diabetic nephropathy (DN) is the major reason for end-stage renal disease in the Western world. Patients with DN developed more severe cardiovascular complications with worse prognosis.
Bo Zheng, Lei Chen, Frank J. Gonzalez
doaj +1 more source
In Vitro Characterization of a Tissue Renin-Angiotensin System in Human Nucleus Pulposus Cells
Cells, 2022 Low back pain is a clinically highly relevant musculoskeletal burden and is associated with inflammatory as well as degenerative processes of the intervertebral disc.
Babak Saravi +9 more
doaj +1 more source
Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications [PDF]
Science Signaling 12 Jan 2021: Vol. 14, Issue 665, eabd0334, 2020 The primary cell surface receptor for SARS-CoV-2 is the angiotensin-converting enzyme 2 (ACE2). Recently it has been noticed that the viral Spike protein has an RGD motif, suggesting that cell surface integrins may be co-receptors. We examined the sequences of ACE2 and integrins with the Eukaryotic Linear Motif resource, ELM, and were presented with ...
arxiv +1 more source
Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2 and cell proliferation via Gαq-mediated mechanism [PDF]
, 2014 Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Bai, B +5 more
core +2 more sources
Advances in Pharmacological and Pharmaceutical Sciences, 2020 Vascular reactivity experiments using isolated aortic rings have been widely used as a model for physiological and pharmacological studies since the early sixties.
Marcos André Soares Leal +5 more
doaj +1 more source
SARS-CoV-2 mortality in blacks and temperature-sensitivity to an angiotensin-2 receptor blocker [PDF]
arXiv, 2020 Tropical climates provoke adaptations in skin pigmentation and in mechanisms controlling the volume, salt-content and pressure of body fluids. For many whose distant ancestors moved to temperate climes, these adaptations proved harmful: pigmentation decreased by natural selection and susceptibility to hypertension emerged.
arxiv
Therapeutic potential of the renin angiotensin system in ischaemic stroke [PDF]
, 2016 The renin angiotensin system (RAS) consists of the systemic hormone system, critically involved in regulation and homeostasis of normal physiological functions [i.e.
Arroja, Mariana Moreira Coutinho +2 more
core +1 more source