In silico ADMET and molecular docking study on searching potential inhibitors from limonoids and triterpenoids for COVID-19 [PDF]
, 2020 Virtual screening of phytochemicals was performed through molecular docking, simulation, in silico ADMET and drug-likeness prediction to identify the potential hits that can inhibit the effects of SARS-CoV-2. Considering the published literature on medicinal importance, total 154 phytochemicals with analogous structure from limonoids and triterpenoids ...
arxiv +1 more source
Renal proximal tubule angiotensin AT1A receptors regulate blood pressure.
American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2011 All components of the renin angiotensin system necessary for ANG II generation and action have been reported to be present in renal proximal convoluted tubules.
Huiping Li +8 more
semanticscholar +1 more source
G protein-coupled receptor dimerisation: molecular basis and relevance to function [PDF]
, 2007 The belief that G protein-coupled receptors exist and function as monomeric, non-interacting species has been largely supplanted in recent years by evidence, derived from a range of approaches, that indicate they can form dimers and/or higher-order ...
Milligan, Graeme
core +1 more source
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.This review highlights emerging bioengineering strategies for treating neointimal hyperplasia in the peripheral vasculature, focusing on approaches that promote re‐endothelialization, modulate smooth muscle cell phenotype, reduce inflammation, mitigate oxidative stress, and optimize biomechanical compliance.
Nikita Wilson John +5 more
wiley +1 more source
The Role of Angiotensin II and Cyclic AMP in Alveolar Active Sodium Transport. [PDF]
PLoS ONE, 2015 Active alveolar fluid clearance is important in keeping airspaces free of edema. Angiotensin II plays a role in the pathogenesis of hypertension, heart failure and others.
Reem Ismael-Badarneh +6 more
doaj +1 more source
Mathematical model of SARS-Cov-2 propagation versus ACE2 fits COVID-19 lethality across age and sex and predicts that of SARS, supporting possible therapy [PDF]
arXiv, 2020 The fatality rate of Covid-19 escalates with age and is larger in men than women. I show that these variations correlate strongly with the level of the viral receptor protein ACE2 in rat lungs, which is consistent with the still limited and apparently contradictory data on human ACE2.
arxiv
Renin-Angiotensin System and Cardiovascular Functions
Arteriosclerosis, Thrombosis and Vascular Biology, 2018 The renin-angiotensin system plays critical roles in maintaining normal cardiovascular functions and contributes to a spectrum of cardiovascular diseases.
Chia-Hua Wu +5 more
semanticscholar +1 more source
G-Protein coupled receptor signalling in pluripotent stem cell-derived cardiovascular cells: Implications for disease modelling [PDF]
, 2015 Human pluripotent stem cell derivatives show promise as an in vitro platform to study a range of human cardiovascular diseases. A better understanding of the biology of stem cells and their cardiovascular derivatives will help to understand the strengths
Dolatshad, NF +4 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Surface modification using mussel‐derived polydopamine (PDA) is a versatile and robust biocompatible strategy that enables direct application to various epidermal surfaces, regardless of their morphological complexity or surface characteristics. The PDA‐coated epidermis exhibits multiple anti‐biofouling functionalities, including antibacterial and anti‐
Su Eon Lee +14 more
wiley +1 more source
Physiology and Pathophysiology of the Intrarenal Renin-Angiotensin System: An Update.
Journal of the American Society of Nephrology, 2017 The renin-angiotensin system (RAS) has a pivotal role in the maintenance of extracellular volume homeostasis and blood pressure through complex mechanisms.
Tianxin Yang, Chuanming Xu
semanticscholar +1 more source