Results 11 to 20 of about 50 (50)
Monomeric and Oligomeric Complexes of the B Cell Antigen Receptor
Immunity, 2000 The current structural model of the B cell antigen receptor (BCR) describes it as a symmetric protein complex in which one membrane-bound immunoglobulin molecule (mIg) is noncovalently bound on each side by an Ig-alpha/Ig-beta heterodimer. Using peptide-tagged Ig-alpha proteins, blue native polyacrylamide gel electrophoresis (BN-PAGE), and ...
Wolfgang W. A. Schamel, Michael Reth
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Molecular requirements of the B‐cell antigen receptor for sensing monovalent antigens
The EMBO Journal, 2016 How the B-cell antigen receptor (BCR) is activated upon interaction with its cognate antigen or with anti-BCR antibodies is not fully understood. We have recently shown that B-cell activation is accompanied by the opening of the pre-organized BCR oligomers, an observation that strengthens the role of receptor reorganization in signalling.
Naema Brings +10 more
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Chimeric antigen receptor T-cells for B-cell malignancies
Translational Research, 2017 The adoptive transfer of T-lymphocytes modified to express chimeric antigen receptors (CAR-Ts) has produced impressive clinical responses among patients with B-cell malignancies. This has led to a rapid expansion in the number of clinical trials over the past several years.
Gianpietro Dotti, Eben I. Lichtman
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B-cell co-receptors: The two-headed antigen [PDF]
Current Biology, 1996 AbstractLymphocytes often recognize antigens using not only their antigen receptors but also ‘co-receptors’ that bind other molecules associated with the antigen; the co-receptors then modulate the response to antigen. This concept has been used to make chimeric antigens that are extremely potent inducers of antibody responses.
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Architecture of the human B-cell antigen receptors [PDF]
Blood, 1993 R. A. W. Van Lier, C. J. M. Van Noesel
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Tuning B cell responsiveness by antigen receptor isotype
Oncotarget, 2015 The expression of functional B cell antigen receptors (BCRs) is essential for development, survival and activation of B cells. During early developmental stages, immature B cells exclusively express IgM. Cells that pass the immature B cell stage and leave the bone marrow coexpress BCRs of IgM and IgD isotypes, which differ in the usage of the heavy ...
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The Maintenance and the Activation Signal of the B-cell Antigen Receptor
Cold Spring Harbor Symposia on Quantitative Biology, 1999 Jürgen Wienands, Michael Reth
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B Cell Receptor and Antigens in CLL [PDF]
, 2013 Nowadays, chronic lymphocytic leukemia (CLL) is considered as a prototypic antigen-driven lymphoma, with antigenic stimuli from the microenvironment promoting tumor outgrowth. Antigen recognition is a function of both the clonotypic B cell receptor immunoglobulin (BcR IG) and various other immune sensors, e.g., the Toll-like receptors.
Andreas Agathangelidis +2 more
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The B-cell antigen receptor complex
Immunology Today, 1991Abstract Here, Michael Reth, John Cambier and colleagues review the genetics, biochemistry and cell biology o f the recently-identified accessory components o f the B-cell antigen receptor.
Kerry S. Campbell +6 more
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