Results 31 to 40 of about 50 (50)
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B-cell development and antigen receptor signalling
Biochemical Society Transactions, 2002B-cell development and function requires the products of the Vav family of genes. Vav proteins act as key components of the antigen receptor signal transduction machinery by integration of signals that control the cell cycle, differentiation and apoptosis.
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Regulation of B-cell fate by antigen-receptor signals
Nature Reviews Immunology, 2002Recent evidence indicates that B cells are instructed continuously by B-cell receptor (BCR) signals to make crucial cell-fate decisions at several checkpoints during their development. Targeted disruption of BCR signalling components leads to distinct blocks in B-cell maturation, which indicates that key kinases and adaptors fine-tune BCR signalling to
Hiroaki Niiro, Edward A. Clark
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Function of B-cell antigen receptor of different classes
Immunology Letters, 1995Most mature B lymphocytes co-express two classes of antigen receptor, IgM and IgD. The differences in the signal transduction from the 2 receptors are still a matter of controversy. We have analysed B-cell lines expressing IgM or IgD antigen receptors with the same antigen specificity.
Kwang-Myong Kim, Michael Reth
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To make antibodies or not: signaling by the B-cell antigen receptor [PDF]
Trends in Pharmacological Sciences, 2002 Antibodies produced by B cells play an essential role in protecting against disease-causing pathogens. B cells detect the presence of pathogens via B-cell antigen receptors (BCRs), which consist of a transmembrane form of an antibody that is associated with a signaling subunit. Signaling by BCRs not only initiates antibody production but also regulates
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Identification of Components of the B Cell Antigen Receptor Complex
1991Immunoglobulins (Ig) are well-known as antibody molecules which are present in the serum of all vertebrate species. The mouse has five classes of Ig (IgM, IgD, IgG, IgA and IgE) and most of these antibody classes have different effector function during an immune response.1 Heavy chains of each Ig class exist also in a membrane-bound form23 which is ...
Jiirgen Wienands +3 more
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Malignant B Cells and Antigenic Receptor: Necessity or Habit?
Leukemia & Lymphoma, 2002B-cell malignancies account for the majority of lymphoid tissue neoplasia. Similar to normal B cells, malignant B cells in most Hodgkin's and non-Hodgkin's types of lymphomas express B-cell receptor (BCR) on their membrane. Since neoplastic B cells retain the capacity to respond to microenvironmental signals, and in many respects still behave as normal
Larry R. Pease, Bogoljub Ciric
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Structure and Function of the B Cell Antigen Receptors
1993The B cell antigen receptor is a complex consisting of the membrane-bound immunoglobulin (mIg) molecule and two B cell-specific transmembrane proteins (Ig-α and Ig-β) which form a covalently linked α/β heterodimer (for review see Reth et al., 1991; Reth, 1992). All five different mIg classes are associated with the same α/β heterodimer (Venkitaraman et
Peter Weiser +4 more
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The B-cell antigen receptor of the five immunoglobulin classes
Nature, 1991Several proteins associate with surface IgM to form the antigen receptor. We show that just two, the alpha and beta associated chains, are sufficient to reconstitute an IgM surface receptor in fibroblasts. Contrary to expectation, a common alpha chain associates with all five immunoglobulin classes. We propose that B-cell antigen receptors consist of a
Ashok R. Venkitaraman +4 more
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Signal transduction from the B cell antigen-receptor
Current Opinion in Immunology, 1999Ligation of the B cell antigen-receptor triggers an intricate maze of intercalated biochemical events that ultimately affect B cell biological responses. Recent advances have helped to connect many loose ends by identifying key adaptor proteins, such as BLNK/SLP-65, defining crucial roles for phosphatidylinositol-3-kinase and mapping pathways ...
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Molecular mechanisms in B cell antigen receptor signaling
Current Opinion in Immunology, 1997Recent gene-targeting experiments have highlighted the importance of the intracellular protein tyrosine kinases Lyn, Syk, and Btk in BCR signal transduction and B cell development. In addition, the interactions of these kinases and their regulatory mechanisms have been reported.
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