Results 31 to 40 of about 1,004,480 (189)

Diverse and reprogrammable mechanisms of malignant cell transformation in lymphocytes: pathogenetic insights and translational implications

Frontiers in Oncology
While normal B- and T-lymphocytes require antigenic ligands to become activated via their B- and T-cell receptors (BCR and TCR, respectively), B- and T-cell lymphomas show the broad spectrum of cell activation mechanisms regarding their dependence on BCR
Mariusz A. Wasik, Patricia M. Kim, Reza Nejati   +2 more
doaj   +1 more source

B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk

eLife, 2014
Binding of antigen to the B cell antigen receptor (BCR) initiates a multitude of events resulting in B cell activation. How the BCR becomes signaling-competent upon antigen binding is still a matter of controversy.
Kathrin Kläsener, Palash C Maity, Elias Hobeika, Jianying Yang, Michael Reth   +4 more
doaj   +1 more source

Dimensionality of Motion and Binding Valency Govern Receptor–Ligand Kinetics As Revealed by Agent-Based Modeling

Frontiers in Immunology, 2017
Mathematical modeling and computer simulations have become an integral part of modern biological research. The strength of theoretical approaches is in the simplification of complex biological systems.
Teresa Lehnert, Teresa Lehnert, Marc Thilo Figge, Marc Thilo Figge, Marc Thilo Figge   +4 more
doaj   +1 more source

B cell activation and affinity discrimination by receptor segregation? [PDF]

, 2005
n/
Gruhn, T., Iber, D., Lipowsky, R., Maini, P. K.   +3 more
core   +1 more source

Distinct Roles for Bruton's Tyrosine Kinase in B Cell Immune Synapse Formation

Frontiers in Immunology, 2018
Bruton's tyrosine kinase (Btk) has a key role in the signaling pathways of receptors essential for the B lymphocyte response. Given its implication in B cell-related immunodeficiencies, leukemias/lymphomas and autoimmunity, Btk is studied intensely and ...
Sara Roman-Garcia, Sara V. Merino-Cortes, Sofia R. Gardeta, Marjolein J. W. de Bruijn, Rudi W. Hendriks, Yolanda R. Carrasco   +5 more
doaj   +1 more source

Expression of interleukin 2 receptors on activated human B cells. [PDF]

, 1984
Using anti-Tac, a monoclonal anti-interleukin 2 (IL-2) receptor antibody, we have explored the possibility that certain activated B cells display receptors for IL-2.
Bongiovanni, KF, Depper, JM, Goldman, CK, Greene, WC, Korsmeyer, SJ, Leonard, WJ, Robb, RJ, Sharrow, SO, Waldmann, TA   +8 more
core  

Genomic donor cassette sharing during VLRA and VLRC assembly in jawless vertebrates

, 2014
Lampreys possess two T-like lymphocyte lineages that express either variable lymphocyte receptor (VLR) A or VLRC antigen receptors. VLRA+ and VLRC+ lymphocytes share many similarities with the two principal T-cell lineages of jawed vertebrates expressing
Aravind, L., Boehm, T., Cooper, M., Das, S., Hirano, M., Holland, S., Iyer, L., Li, J., Schorrp, M.   +8 more
core   +1 more source

Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer. [PDF]

, 2017
BackgroundT cells engineered to express chimeric antigen receptors (CARs) have established efficacy in the treatment of B-cell malignancies, but their relevance in solid tumors remains undefined.
A Molinolo, A Stasi Di, A Thor, B Fisher, BA Irving, BL Levine, C Romeo, CC Kloss, CY Wu, D Moritz, DL Porter, DW Lee, F Guadagni, HM Finney, I Blanco, I Stancovski, J Scholler, JD Wolchok, JL Murray, JN Kochenderfer, JW Greiner, KD Griffith, L Naldini, M Hegde, M Kalos, ME Dudley, MH Finer, MH Kershaw, ML Davila, MR Lander, N Gonzales, NP Restifo, P Hwu, RA Morgan, RE Walker, RF Meredith, RP McGuinness, RT Mitsuyasu, S Guedan, SD Patel, SG Deeks, SL Maude, SV Kashmiri   +42 more
core   +1 more source

Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis. [PDF]

, 2018
Peritoneal metastasis (PM) is an advanced stage malignancy largely refractory to modern therapy. Intraperitoneal (IP) immunotherapy offers a novel approach for the control of regional disease of the peritoneal cavity by breaking immune tolerance.
Bowne, Wilbur B., Katz, Steven C., Khalili, Marian, Morano, William F., Richard, Scott D., Thadi, Anusha   +5 more
core   +2 more sources

Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma

Nature Communications, 2020
Nodular lymphocyte-predominant Hodgkin lymphoma with IgD+ lymphocyte-predominant (LP) cells is a rare clinical distinct lymphoma subset of B-cell origin.
Lorenz Thurner, Sylvia Hartmann, Natalie Fadle, Evi Regitz, Maria Kemele, Yoo-Jin Kim, Rainer Maria Bohle, Anna Nimmesgern, Lutz von Müller, Volkhard A. J. Kempf, Marc A. Weniger, Frank Neumann, Nadine Schneider, Martine Vornanen, Christer Sundström, Laurence de Leval, Andreas Engert, Dennis A. Eichenauer, Ralf Küppers, Klaus-Dieter Preuss, Martin-Leo Hansmann, Michael Pfreundschuh   +21 more
doaj   +1 more source