Results 91 to 100 of about 26,522 (128)

Expression of T cell receptor gamma delta antigens in human brain tissue.

Neuroimmunomodulation, 1996
The human gamma delta T cell receptor (TCR) is normally expressed on lymphoid tissue. Since expression of different molecules of the T cell system has been described for human brain cells, we examined the expression of CD4 and TCR gamma delta antigens with a panel of various anti-gamma delta TCR monoclonal antibodies (mAbs) and an anti-CD4 mAb using ...
K H, Frenzel, N, Müller, D, Heidmann, H, Hampel, H A, Kretzschmar, R, Penning, M, Ackenheil   +6 more
openaire   +1 more source

Antigen specific and MHC nonrestricted cytotoxicity of T cell receptor alpha beta+ and gamma delta+ human T cell clones isolated in IL-4.

The Journal of Immunology, 1989
Abstract IL-4 has been shown to act as a growth factor for human T cells. In addition, IL-4 can enhance CTL activity in MLC, but blocks IL-2 induced lymphokine activated killer cell activity in PBL. In our study, the cloning efficiencies, Ag-specific CTL activity and non-MHC-restricted cytotoxicity of CTL clones generated in IL-2 were ...
Paliard, X., Yssel, H., Blanchard, D., Waitz, J. A., deVries, J. E., Spits, H.   +5 more
openaire   +3 more sources

Characterization of T cells expressing the γ/δ antigen receptor in human renal allografts

Human Immunology, 1993
To investigate the role of gamma/delta+ T cells in allograft rejection, we have studied the TCR phenotype and function of lymphocytes infiltrating rejecting, rejected, and nonrejecting human renal allografts. Two-color immunohistologic staining showed that 19% of rejecting biopsies and 40% of rejected nephrectomies had significant infiltration (> 10 ...
A D, Kirk, S, Ibrahim, D V, Dawson, F, Sanfilippo, O J, Finn   +4 more
openaire   +2 more sources

Functional expression of CD28 on T cell antigen receptor γ/δ‐bearing T lymphocytes

European Journal of Immunology, 1989
AbstractT lymphocytes express a T cell antigen receptor (TcR) complex composed of either an TcR α/β or TcR γ/δ heterodimer in noncovalent association with the CD3 glycoproteins. CD28, a 44‐kDa disulfide‐linked homodimer, is present on the surface of the majority of TcR α/β‐bearing T lymphocytes.
R, Testi, L L, Lanier
openaire   +2 more sources

Lymphocytes bearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions

Nature, 1989
The majority of T cells bear the T-cell receptor (TCR) alpha beta complex which recognizes foreign antigen peptides only in the context of self major histocompatibility complex (MHC) molecules. Such T cells function in a variety of effector roles and secrete cytokines that mediate the activation and differentiation of other cells in the immune system ...
R L, Modlin, C, Pirmez, F M, Hofman, V, Torigian, K, Uyemura, T H, Rea, B R, Bloom, M B, Brenner   +7 more
openaire   +2 more sources

Preferential tissue localization of bovine γδ T cell subsets defined by anti-T cell receptor for antigen antibodies

Immunology Letters, 1998
Clonal and oligoclonal populations of gammadelta T cells, with respect to the expression of T cell receptors for antigen (Tcr), have been shown to localize in normal and inflamed tissues. The mechanisms responsible for the tissue-selective accumulation of these subsets are still not known. gammadelta T cells are the predominant T cell subset in newborn
E, Wilson, B, Walcheck, W C, Davis, M A, Jutila   +3 more
openaire   +2 more sources

T cell receptor positive T cells in the inflammatory joint: Lack of association with response to soluble antigens

Cellular Immunology, 1991
In patients with inflammatory synovitis, the proliferative response by lymphocytes from synovial fluid to soluble mycobacterial antigens is enhanced relative to those from peripheral blood. Earlier studies suggested that gamma/delta T cell receptor positive (TCR+) T lymphocytes may significantly contribute to the mycobacterial-specific synovial fluid ...
R M, Pope, A, Landay, R L, Modlin, J, Lessard, A E, Koch   +4 more
openaire   +2 more sources

T cell receptor gamma delta repertoire is skewed in cerebrospinal fluid of multiple sclerosis patients: molecular and functional analyses of antigen-reactive gamma delta clones.

European journal of immunology, 1995
To study the relevance of gamma delta T cells in multiple sclerosis (MS) we analyzed the T cell receptor (TCR) gamma delta repertoire and the antigen reactivity of gamma delta clones isolated from cerebrospinal fluid (CSF). In T cell cultures derived from CSF we found an increased percentage of V delta 1+ cells as compared to peripheral blood of the ...
S, Nick, P, Pileri, S, Tongiani, Y, Uematsu, L, Kappos, G, De Libero   +5 more
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Murine T cells with invariant gamma delta antigen receptors: origin, repertoire, and specificity.

Seminars in immunology, 1991
T cells bearing invariant gamma delta T cell antigen receptors localize to distinct epithelial sites in the adult mouse. These gamma delta T cells differ from the lymphoid alpha beta and gamma delta T cells in several ways. The epithelial gamma delta T cells appear to be the product of the earliest waves of TCR expressing cells in the fetal thymus ...
W L, Havran, A, Carbone, J P, Allison
openaire   +1 more source

γ/δ T cell antigen receptors expressed on tumor‐infiltrating lymphocytes from patients with solid tumors

European Journal of Immunology, 1992
AbstractThe expression of γ/δ T cell antigen receptors (TcR) in T cell lines or clones derived from tumor‐infiltrating lymphocytes (TIL) from patients with solid tumors was investigated. γ/δ TcR T cell lines were derived from TIL from patients with Wilms tumor, sarcoma or metastatic melanoma by stimulation with autologous tumor cells alone and ...
M, Nanno, H, Seki, G, Mathioudakis, R, Suzuki, K, Itoh, C G, Ioannides, S, Suzuki, P F, Chen, C D, Platsoucas   +8 more
openaire   +2 more sources