Results 211 to 220 of about 15,411,883 (261)

Human T lymphocytes expressing gamma/delta T cell antigen receptor.

Clinical immunology and immunopathology, 1989
The majority of mature T lymphocytes express CD3-associated antigen receptor molecules (TCR) formed by alpha and beta chains. Recently, a minor subset has been identified that expresses a different CD3-associated heterodimer composed of gamma and delta chains. The TCR gamma/delta+ cell subset differs from conventional T cells for a number of phenotypic
MORETTA, ALESSANDRO, CICCONE, ERMANNO, MINGARI, MARIA CRISTINA, BOTTINO, CRISTINA, Ferrini S, Tambussi G, Melioli G, GROSSI, CARLO ENRICO, MORETTA, LORENZO   +8 more
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Cytotoxicity of Human Hepatic Intrasinusoidal Gamma/Delta T Cells Depends on Phospho-antigen and NK Receptor Signaling

Anticancer Research, 2022
We previously showed that human hepatic intrasinusoidal (HI) natural killer (NK) T cells selectively eliminate hepatocellular carcinoma (HCC) cell lines. In this study, we investigated the underlying mechanisms on how HI γδ T cells, expanded with zoledronate, exhibit a superior cytotoxic effect on HI NK-resistant Huh7 HCC cells.γδ T cells were obtained
Yoorha, Kang, Mina, Han, Minsong, Kim, Hyun Ju, Hwang, Byung Chan, Ahn, Eunyoung, Tak, Gi-Won, Song, Shin, Hwang, Kyung-Nam, Koh, Dong-Hwan, Jung, Nayoung, Kim   +10 more
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Crystal structure of a MIC-reactive gamma-delta T cell receptor - insights into gamma-delta TCR antigen recognition (134.79)

The Journal of Immunology, 2009
Abstract Gamma-delta T cells play essential roles in the immune surveillance and elimination of tumor cells and various types of infection. However, little is known about the recognition mechanisms of human gamma-delta TCRs. MHC class I-related chain (MIC) is one of only two validated protein ligands for human gamma-delta TCRs.
Bin Xu, Juan C. Pizarro, Meg Holmes, Roland K. Strong   +3 more
openaire   +1 more source

Recognition of Self Antigens by Skin-Derived T Cells with Invariant γδ Antigen Receptors

Science, 1991
Thy-1 + dendritic epidermal T cells (dECs) express invariant γδ antigen receptors and are found in intimate contact with keratinocytes in murine epidermis—thus raising the possibility that keratinocytes express a ligand for the antigen receptor of these T cells.
W L, Havran, Y H, Chien, J P, Allison
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Development of Novel Chimeric Antigen Receptors Targeting the Gamma-Delta (γδ) T-Cell Receptor

Blood
γδ T-cell receptors (TCRs) are made up of γ and δ chains that are each composed of a constant region and a variable region. Several aggressive malignancies express γδ TCRs including hepatosplenic T-cell lymphoma and some cases of T-cell acute lymphoblastic leukemia.
Lauren C Cutmore, Norris Lam, Christina Amatya, Katherine A Weissler, Danielle A Natrakul, James N Kochenderfer   +5 more
openaire   +1 more source

A novel gamma delta T cell receptor for antigen adds limited diversity to the gamma delta repertoire in adult thymus.

The Journal of Immunology, 1989
Abstract The surface expression of CD3-associated TCR chains on hybridoma cell lines derived from adult gamma delta thymocytes was analyzed. These cell lines were unusual, in that a) they expressed a surface heterodimer consisting of a 40- and a 42-kDa chain, i.e., comprised of chains different from any previously reported gamma delta-
Marusić Galesić, S, Saito, T, TENTORI, LUCIO, Zuñiga Pflucker, J, Raulet, D, Allison, J, Kruisbeek, A.   +6 more
openaire   +3 more sources

Signal transduction of gamma/delta T cell antigen receptor with a novel mitogenic anti-delta antibody.

The Journal of Immunology, 1988
Abstract Human T lymphocytes express either alpha/beta- or gamma/delta-TCR in association with the CD3 complex. We have isolated a mAb, delta TCS1, that immunoprecipitated the gamma/delta-TCR heterodimer from cell lysates of Peer and Molt-13 leukemia cell lines.
Y J, Wu, W T, Tian, R M, Snider, C, Rittershaus, P, Rogers, L, LaManna, S H, Ip   +6 more
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Antigen specific and MHC nonrestricted cytotoxicity of T cell receptor alpha beta + and gamma delta+ human T cell clones isolated in IL-4.

The Journal of Immunology, 1989
Abstract IL-4 has been shown to act as a growth factor for human T cells. In addition, IL-4 can enhance CTL activity in MLC, but blocks IL-2 induced lymphokine activated killer cell activity in PBL. In our study, the cloning efficiencies, Ag-specific CTL activity and non-MHC-restricted cytotoxicity of CTL clones generated in IL-2 were
Paliard, X., Yssel, H., Blanchard, D., Waitz, J. A., deVries, J. E., Spits, H.   +5 more
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Expression of T cell receptor gamma delta antigens in human brain tissue.

Neuroimmunomodulation, 1996
The human gamma delta T cell receptor (TCR) is normally expressed on lymphoid tissue. Since expression of different molecules of the T cell system has been described for human brain cells, we examined the expression of CD4 and TCR gamma delta antigens with a panel of various anti-gamma delta TCR monoclonal antibodies (mAbs) and an anti-CD4 mAb using ...
K H, Frenzel, N, Müller, D, Heidmann, H, Hampel, H A, Kretzschmar, R, Penning, M, Ackenheil   +6 more
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Characterization of T cells expressing the γ/δ antigen receptor in human renal allografts

Human Immunology, 1993
To investigate the role of gamma/delta+ T cells in allograft rejection, we have studied the TCR phenotype and function of lymphocytes infiltrating rejecting, rejected, and nonrejecting human renal allografts. Two-color immunohistologic staining showed that 19% of rejecting biopsies and 40% of rejected nephrectomies had significant infiltration (> 10 ...
A D, Kirk, S, Ibrahim, D V, Dawson, F, Sanfilippo, O J, Finn   +4 more
openaire   +2 more sources