Results 191 to 200 of about 15,411,883 (261)

3D Culture Reverses Limbal Niche Cell Replicative Aging via FOSL1 Upregulation

Aging Cell, Volume 25, Issue 9, September 2026.
3D culture reverses LNC replicative aging via FOSL1 upregulation, enhancing mitochondrial function and alleviating oxidative stress. ABSTRACT Limbal niche cells (LNCs) serve as essential regulators of limbal microenvironmental homeostasis and corneal epithelial wound repair, representing a promising therapeutic resource for limbal stem cell deficiency (
Xuying Wang, Shen Li, Zibin Liu, Xinghan Guo, Jiachao Shen, Tianyu Zhou, Shuying Liao, Xiaoyu Huang, Wei Wang, Lingjuan Xu, Xinjie Zang, Guigang Li   +11 more
wiley   +1 more source

Long-term major histocompatibility complex class I suppression in astronauts and clinical implications. [PDF]

Commun Biol
LeRoy E, Kim J, Ruland H, Schanzer N, Sakharkar A, Innes L, Feinstein Z, Gamboa DZ, Chen R, Arikatla MR, Kurt KC, Crucian BE, Schmidt MA, Mason CE.   +13 more
europepmc   +1 more source

Immune features of graft‐derived mucosal‐associated invariant T cells predict gastrointestinal graft‐versus‐host disease

British Journal of Haematology, Volume 209, Issue 3, Page 1208-1219, September 2026.
Summary Gastrointestinal acute graft‐versus‐host disease (GI aGVHD) remains a major complication after allogeneic haematopoietic stem cell transplantation (allo‐HSCT), and early risk identification and intervention are essential for improving outcomes.
Gao Mengge, Cheng Rongqi, Kong Jun, Sun Yuqian, Wang Zhidong, Sun Hui, Chang Yingjun, Huang Xiaojun, Zhao Xiaosu   +8 more
wiley   +1 more source

PSCA CAR Vδ1 T cells: a safer off-the-shelf CAR T therapy for pancreatic cancer? [PDF]

J Immunother Cancer
Fraietta JA, Lohmueller JJ.
europepmc   +1 more source

Diverging in Vivo Immune Response Patterns After Oral Food Challenge in Peanut Allergic Adults

Clinical &Experimental Allergy, Volume 56, Issue 9, Page 1063-1075, September 2026.
After the oral food challenge, peanut (PN)‐allergic adults were monitored over 4 weeks, which revealed diverging immune response patterns, with strong responders (SR) exhibiting heightened Ara h 2+ B cell expansion, PN sIgE induction and increasing PN‐specific Tconv. Weak responders (WR) had more activated PN‐specific Tregs.
Florent Fauchère, Aikaterina Alexiou, Veronika Höfer, Kirsten Beyer, Sabine Dölle‐Bierke, Andreas Thiel, Margitta Worm, Julian Braun   +7 more
wiley   +1 more source

Efficient multiplex non-viral engineering and expansion of polyclonal γδ CAR-T cells for immunotherapy. [PDF]

Mol Ther
Bridge J, Johnson MJ, Kar B, Kim J, Wenthe S, Krueger J, Wick B, Kluesner MG, Crane AT, Bell J, von Dissen L, Stelljes E, Skeate JG, Moriarity BS, Webber BR.   +14 more
europepmc   +1 more source

Impact of G‐CSF on Donor TCR Clonal Diversity and T Cell Function During Donor HSC Mobilisation

Cell Proliferation, Volume 59, Issue 9, September 2026.
In this study, we found that G‐CSF mobilisation caused a reduction in TCR clonal diversity and down‐regulation of T‐cell function in donors. This may be one of the reasons for the low incidence of GVHD mediated by G‐CSF after allo‐HSCT. Source: Created in BioRender. Li https://BioRender.com/otownki.
Xinye Li, Zhixi Chen, Jie Chen, Xingwei Zhang, Jiamian Zheng, Zirui Liu, Meixue Pan, Yue Li, Bo Yu, Shaohua Chen, Jing Lai, Xianfeng Zha, Liye Zhong, Yikai Zhang, Yangqiu Li   +14 more
wiley   +1 more source

The double-edged nature of antibody bivalency: mathematical and experimental analysis of cell surface antigen occupancy and opsonization. [PDF]

MAbs
Heirene L, Lodge J, Fedorova M, Gauntlett R, Cordy J, Rattray Z, Byrne H, Gaffney E, Yates JWT.   +8 more
europepmc   +1 more source

Engineering gamma delta T cells limits tonic signaling associated with chimeric antigen receptors

, 2019
Fisher, J, Sharma, R, Don, DW, Barisa, M, Hurtado, MO, Abramowski, P, Porter, L, Day, W, Borea, R, Inglott, S, Anderson, J, Pe'er, D   +11 more
openaire   +1 more source

Structural T‐Cell Receptor Analysis in the Age of Machine Learning

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT The development of highly accurate deep learning models for protein structure prediction has transformed the landscape of T‐cell receptor (TCR) structure data, which can now be accessed at repertoire scale. We provide a perspective on the growing field of structural TCR immunoinformatics, summarizing core principles of TCR structural biology ...
Nele P. Quast, Matthew I. J. Raybould, Charlotte M. Deane   +2 more
wiley   +1 more source