Results 181 to 190 of about 27,293 (229)

Crystal structure of a MIC-reactive gamma-delta T cell receptor - insights into gamma-delta TCR antigen recognition (134.79)

The Journal of Immunology, 2009
Abstract Gamma-delta T cells play essential roles in the immune surveillance and elimination of tumor cells and various types of infection. However, little is known about the recognition mechanisms of human gamma-delta TCRs. MHC class I-related chain (MIC) is one of only two validated protein ligands for human gamma-delta TCRs.
Bin Xu, Juan C. Pizarro, Meg Holmes, Roland K. Strong   +3 more
openaire   +1 more source

Recognition of Self Antigens by Skin-Derived T Cells with Invariant γδ Antigen Receptors

Science, 1991
Thy-1 + dendritic epidermal T cells (dECs) express invariant γδ antigen receptors and are found in intimate contact with keratinocytes in murine epidermis—thus raising the possibility that keratinocytes express a ligand for the antigen receptor of these T cells.
W L, Havran, Y H, Chien, J P, Allison
openaire   +2 more sources

A novel gamma delta T cell receptor for antigen adds limited diversity to the gamma delta repertoire in adult thymus.

The Journal of Immunology, 1989
Abstract The surface expression of CD3-associated TCR chains on hybridoma cell lines derived from adult gamma delta thymocytes was analyzed. These cell lines were unusual, in that a) they expressed a surface heterodimer consisting of a 40- and a 42-kDa chain, i.e., comprised of chains different from any previously reported gamma delta-
Marusić Galesić, S, Saito, T, TENTORI, LUCIO, Zuñiga Pflucker, J, Raulet, D, Allison, J, Kruisbeek, A.   +6 more
openaire   +3 more sources

Development of Novel Chimeric Antigen Receptors Targeting the Gamma-Delta (γδ) T-Cell Receptor

Blood
γδ T-cell receptors (TCRs) are made up of γ and δ chains that are each composed of a constant region and a variable region. Several aggressive malignancies express γδ TCRs including hepatosplenic T-cell lymphoma and some cases of T-cell acute lymphoblastic leukemia.
Lauren C Cutmore, Norris Lam, Christina Amatya, Katherine A Weissler, Danielle A Natrakul, James N Kochenderfer   +5 more
openaire   +1 more source

Signal transduction of gamma/delta T cell antigen receptor with a novel mitogenic anti-delta antibody.

The Journal of Immunology, 1988
Abstract Human T lymphocytes express either alpha/beta- or gamma/delta-TCR in association with the CD3 complex. We have isolated a mAb, delta TCS1, that immunoprecipitated the gamma/delta-TCR heterodimer from cell lysates of Peer and Molt-13 leukemia cell lines.
Y J, Wu, W T, Tian, R M, Snider, C, Rittershaus, P, Rogers, L, LaManna, S H, Ip   +6 more
openaire   +2 more sources

Antigen specific and MHC nonrestricted cytotoxicity of T cell receptor alpha beta + and gamma delta+ human T cell clones isolated in IL-4.

The Journal of Immunology, 1989
Abstract IL-4 has been shown to act as a growth factor for human T cells. In addition, IL-4 can enhance CTL activity in MLC, but blocks IL-2 induced lymphokine activated killer cell activity in PBL. In our study, the cloning efficiencies, Ag-specific CTL activity and non-MHC-restricted cytotoxicity of CTL clones generated in IL-2 were
Paliard, X., Yssel, H., Blanchard, D., Waitz, J. A., deVries, J. E., Spits, H.   +5 more
openaire   +3 more sources

Characterization of T cells expressing the γ/δ antigen receptor in human renal allografts

Human Immunology, 1993
To investigate the role of gamma/delta+ T cells in allograft rejection, we have studied the TCR phenotype and function of lymphocytes infiltrating rejecting, rejected, and nonrejecting human renal allografts. Two-color immunohistologic staining showed that 19% of rejecting biopsies and 40% of rejected nephrectomies had significant infiltration (> 10 ...
A D, Kirk, S, Ibrahim, D V, Dawson, F, Sanfilippo, O J, Finn   +4 more
openaire   +2 more sources

Expression of T cell receptor gamma delta antigens in human brain tissue.

Neuroimmunomodulation, 1996
The human gamma delta T cell receptor (TCR) is normally expressed on lymphoid tissue. Since expression of different molecules of the T cell system has been described for human brain cells, we examined the expression of CD4 and TCR gamma delta antigens with a panel of various anti-gamma delta TCR monoclonal antibodies (mAbs) and an anti-CD4 mAb using ...
K H, Frenzel, N, Müller, D, Heidmann, H, Hampel, H A, Kretzschmar, R, Penning, M, Ackenheil   +6 more
openaire   +1 more source

T cell receptor positive T cells in the inflammatory joint: Lack of association with response to soluble antigens

Cellular Immunology, 1991
In patients with inflammatory synovitis, the proliferative response by lymphocytes from synovial fluid to soluble mycobacterial antigens is enhanced relative to those from peripheral blood. Earlier studies suggested that gamma/delta T cell receptor positive (TCR+) T lymphocytes may significantly contribute to the mycobacterial-specific synovial fluid ...
R M, Pope, A, Landay, R L, Modlin, J, Lessard, A E, Koch   +4 more
openaire   +2 more sources

Surface Expression of Two Distinct Functional Antigen Receptors on Human γδ T Cells

Science, 1993
Lymphocytes recognize antigens with highly variable heterodimeric surface receptors. Although four distinct antigen receptors could in principle be produced by any lymphocyte, only one functional combination of receptor chains has thus far been found expressed on their surface.
F, Davodeau, M A, Peyrat, I, Houde, M M, Hallet, G, De Libero, H, Vié, M, Bonneville   +6 more
openaire   +2 more sources