Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer +4 more
wiley +1 more source
The Potential of Intraepithelial Lymphocytes as Immunological Targets for the Induction of Innate and Adaptive Memory Responses Through Mucosal Vaccination and Prime Boost. [PDF]
Guerrero-Manríquez GG +1 more
europepmc +1 more source
Natural Product‐Derived Vesicles in Nanotherapeutics
Natural product‐derived vesicles (NPVs) are an emerging nature‐based nanotherapeutic that can deliver bioactive metabolites into the target site and induce beneficial mechanisms. A practical, chronological bench‐to‐bedside approach throughout the entire NPV development process is expected to resolve challenges encountered in NPV studies.
Kartiko Arif Purnomo, Tsong‐Long Hwang
wiley +1 more source
The role of notch signaling in tumor angiogenesis in hematological malignancies. [PDF]
Tamma R, Benagiano V, Ribatti D.
europepmc +1 more source
ABSTRACT Chickpea (Cicer arietinum L.) is an important dietary legume worldwide and provides micronutrients and phytochemicals, including phenolics, flavonoids, carotenoids, bioactive peptides, dietary fiber, and resistant starch. This narrative review summarizes evidence from in vitro, animal, and human studies on the potential health relevance of ...
Rohama Shahid +4 more
wiley +1 more source
Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2-deficient environments. [PDF]
Blanco-Domínguez R +10 more
europepmc +1 more source
Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang +10 more
wiley +1 more source
Temporal single-cell transcriptional dynamics of murine pancreatic islet remodeling during hyperglycaemia progression. [PDF]
Singh S +10 more
europepmc +1 more source
SARS‐CoV‐2 infection causes COVID‐19 and stimulates immune cells, such as dendritic cells, monocytes, and macrophages, to increase levels of many cytokines. Ursodeoxycholic acid (UDCA) inhibits farnesoid X receptor (FXR), resulting in a decrease in the activity of angiotensin‐converting enzyme 2 (ACE2), the main receptor on the membrane for SARS‐CoV‐2.
Zhaowei Tong +8 more
wiley +1 more source
Genetic engineering and allogeneic optimization of Vδ1 γδ CAR-T cells (ADI-270) for cancer immunotherapy. [PDF]
Liu W, Moriarity BS, Webber BR.
europepmc +1 more source

