Results 81 to 90 of about 26,522 (128)

The Immunobiology Of T Cells With Invariant Gamma-Delta Antigen Receptors

Annual Review of Immunology, 1991
T cells bearing specific gamma delta TCR are the major lymphoid population in certain epithelial tissues. There are striking differences between these and peripheral T cells. The epithelial gamma delta T cells exhibit highly restricted V gene use, preferential pairing of TCR chains, and lack of diversity at the junctions creating populations of cells ...
J P, Allison, W L, Havran
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Cytotoxicity of Human Hepatic Intrasinusoidal Gamma/Delta T Cells Depends on Phospho-antigen and NK Receptor Signaling

Anticancer Research, 2022
We previously showed that human hepatic intrasinusoidal (HI) natural killer (NK) T cells selectively eliminate hepatocellular carcinoma (HCC) cell lines. In this study, we investigated the underlying mechanisms on how HI γδ T cells, expanded with zoledronate, exhibit a superior cytotoxic effect on HI NK-resistant Huh7 HCC cells.γδ T cells were obtained
Yoorha, Kang, Mina, Han, Minsong, Kim, Hyun Ju, Hwang, Byung Chan, Ahn, Eunyoung, Tak, Gi-Won, Song, Shin, Hwang, Kyung-Nam, Koh, Dong-Hwan, Jung, Nayoung, Kim   +10 more
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A novel gamma delta T cell receptor for antigen adds limited diversity to the gamma delta repertoire in adult thymus.

The Journal of Immunology, 1989
Abstract The surface expression of CD3-associated TCR chains on hybridoma cell lines derived from adult gamma delta thymocytes was analyzed. These cell lines were unusual, in that a) they expressed a surface heterodimer consisting of a 40- and a 42-kDa chain, i.e., comprised of chains different from any previously reported gamma delta ...
Marusić Galesić, S, Saito, T, TENTORI, LUCIO, Zuñiga Pflucker, J, Raulet, D, Allison, J, Kruisbeek, A.   +6 more
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Crystal structure of a MIC-reactive gamma-delta T cell receptor - insights into gamma-delta TCR antigen recognition (134.79)

The Journal of Immunology, 2009
Abstract Gamma-delta T cells play essential roles in the immune surveillance and elimination of tumor cells and various types of infection. However, little is known about the recognition mechanisms of human gamma-delta TCRs. MHC class I-related chain (MIC) is one of only two validated protein ligands for human gamma-delta TCRs.
Bin Xu, Juan C. Pizarro, Meg Holmes, Roland K. Strong   +3 more
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Recognition of Self Antigens by Skin-Derived T Cells with Invariant γδ Antigen Receptors

Science, 1991
Thy-1 + dendritic epidermal T cells (dECs) express invariant γδ antigen receptors and are found in intimate contact with keratinocytes in murine epidermis—thus raising the possibility that keratinocytes express a ligand for the antigen receptor of these T cells.
W L, Havran, Y H, Chien, J P, Allison
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IL‐2‐Dependent Murine T‐Cell Lines and Clones Expressing Gamma/Delta T‐Cell Antigen Receptors. I, Functional and Biochemical Characterization

Scandinavian Journal of Immunology, 1991
We have developed two stable IL‐2‐dependenl T‐cell lines designated AKV‐I and AKV‐N from the enlarged spleens, respectively, of an AKV l and an NFS mouse, Immunofluorescence staining with the appropriate monoclonal antibodies revealed that cells of the AKV‐I cell line were αβJTCR‐CD3+CD4‐ CD5‐ CD8+CD25+. Where as cells of the AKV‐N cell line were αβTCR‐
J J, Morkowski, M, Nanno, P F, Chen, K, Itoh, C G, Ioannides, E, Kruzel, F F, Becker, C D, Platsoucas   +7 more
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Development of Novel Chimeric Antigen Receptors Targeting the Gamma-Delta (γδ) T-Cell Receptor

Blood
γδ T-cell receptors (TCRs) are made up of γ and δ chains that are each composed of a constant region and a variable region. Several aggressive malignancies express γδ TCRs including hepatosplenic T-cell lymphoma and some cases of T-cell acute lymphoblastic leukemia.
Lauren C Cutmore, Norris Lam, Christina Amatya, Katherine A Weissler, Danielle A Natrakul, James N Kochenderfer   +5 more
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Signal transduction of gamma/delta T cell antigen receptor with a novel mitogenic anti-delta antibody.

The Journal of Immunology, 1988
Abstract Human T lymphocytes express either alpha/beta- or gamma/delta-TCR in association with the CD3 complex. We have isolated a mAb, delta TCS1, that immunoprecipitated the gamma/delta-TCR heterodimer from cell lysates of Peer and Molt-13 leukemia cell lines.
Y J, Wu, W T, Tian, R M, Snider, C, Rittershaus, P, Rogers, L, LaManna, S H, Ip   +6 more
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Surface Expression of Two Distinct Functional Antigen Receptors on Human γδ T Cells

Science, 1993
Lymphocytes recognize antigens with highly variable heterodimeric surface receptors. Although four distinct antigen receptors could in principle be produced by any lymphocyte, only one functional combination of receptor chains has thus far been found expressed on their surface.
F, Davodeau, M A, Peyrat, I, Houde, M M, Hallet, G, De Libero, H, Vié, M, Bonneville   +6 more
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Activation of Phenotypically Heterogeneous Murine T Cell Receptor γδ+ Dendritic Epidermal T Cells by Self-Antigen(s)

International Archives of Allergy and Immunology, 1995
Adult murine epidermis contains a population of Thy-1+, CD45+, CD3+, CD4- and CD8- in situ primarily T cell receptor (TCR) V gamma 3+/V delta 1+ dendritic epidermal T cells (DETC). In the present study, cell surface phenotypes as well as functional properties of DETC were characterized by using in vitro mitogen-stimulated short-term- (10 days) and ...
H, Huber, P, Descossy, E, Regier, R, van Brandwijk, J, Knop   +4 more
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