Results 91 to 100 of about 836,416 (221)

The application of CAR-T cell therapy in hematological malignancies: advantages and challenges

Acta Pharmaceutica Sinica B, 2018
Chimeric antigen receptor T cell (CAR-T cell) therapy is a novel adoptive immunotherapy where T lymphocytes are engineered with synthetic receptors known as chimeric antigen receptors (CAR).
Zijun Zhao, Yu Chen, Ngiambudulu M. Francisco, Yuanqing Zhang, Minhao Wu   +4 more
doaj  

Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

Journal of Experimental Medicine, 2002
To identify endocytic receptors that allow dendritic cells (DCs) to capture and present antigens on major histocompatibility complex (MHC) class I products in vivo, we evaluated DEC-205, which is abundant on DCs in lymphoid tissues.
L. Bonifaz, D. Bonnyay, K. Mahnke, M. Rivera, M. Nussenzweig, R. Steinman   +5 more
semanticscholar   +1 more source

The T cell antigen receptor [PDF]

Biochemical Journal, 1985
M J Owen, M K L Collins
openaire   +3 more sources

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

Science Translational Medicine, 2014
CD19 CAR T cell therapy induces complete remissions in 88% of 16 adult patients with relapsed or refractory acute lymphoblastic leukemia. CARving Out a Niche for CAR T Cell Immunotherapy Relapsed or refractory B acute lymphoblastic leukemia (B-ALL) in ...
M. Davila, I. Rivière, Xiuyan Wang, S. Bartido, Jae H. Park, K. Curran, S. Chung, J. Stefanski, Oriana Bórquez-Ojeda, M. Olszewska, Jinrong Qu, Teresa Wasielewska, Q. He, Mitsú J. Fink, Himaly Shinglot, M. Youssif, M. Satter, Yongzeng Wang, James Hosey, Hilda Quintanilla, E. Halton, Y. Bernal, Diana C. G. Bouhassira, M. Arcila, M. Gonen, G. Roboz, P. Maslak, D. Douer, M. Frattini, S. Giralt, M. Sadelain, R. Brentjens   +31 more
semanticscholar   +1 more source

Deep learning-based prediction of the T cell receptor–antigen binding specificity

Nature Machine Intelligence, 2021
Tianshi Lu, Ze Zhang, James Zhu, Yunguan Wang, Peixin Jiang, Xue Xiao, C. Bernatchez, J. Heymach, D. Gibbons, Jun Wang, Lin Xu, A. Reuben, Tao Wang   +12 more
semanticscholar   +1 more source

Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy

Journal of the National Cancer Institute, 2016
The genetic modification and characterization of T-cells with chimeric antigen receptors (CARs) allow functionally distinct T-cell subsets to recognize specific tumor cells.
Hanren Dai, Yao Wang, Xuechun Lu, W. Han
semanticscholar   +1 more source

Petri-net modeling of B-cell receptor signaling pathways: A case study in CLL [PDF]

arXiv, 2019
Immunology is the emerging research area which deals with the study of the immune system in any living organism. It is modelled through various computational and mathematical models to deal with the problem facing while to boost the immune system of an organism or to fight with the infectious disease at the very initial stage.
arxiv  

CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions.

Annual Review of Medicine, 2018
Antigen-specific CD8 T cells are central to the control of chronic infections and cancer, but persistent antigen stimulation results in T cell exhaustion. Exhausted CD8 T cells have decreased effector function and proliferative capacity, partly caused by
M. Hashimoto, A. Kamphorst, S. Im, H. Kissick, R. Pillai, S. Ramalingam, K. Araki, R. Ahmed   +7 more
semanticscholar   +1 more source

Detection of mutant antigen-specific T cell receptors against multiple myeloma for T cell engineering

Molecular Therapy: Methods & Clinical Development, 2023
Multiple myeloma (MM) remains an incurable hematological neoplasm. Neoantigen-specific T cell receptor (TCR)-engineered T (TCR-T) cell therapy is a potential alternative treatment.
Masahiro Okada, Kanako Shimizu, Hiroshi Nakazato, Satoru Yamasaki, Shin-ichiro Fujii   +4 more
doaj  

Stories From the Dendritic Cell Guardhouse

Frontiers in Immunology, 2019
Phagocytic cells [dendritic cells (DCs), macrophages, monocytes, neutrophils, and mast cells] utilize C-type (Ca2+-dependent) lectin-like (CLEC) receptors to identify and internalize pathogens or danger signals.
J. Kenneth Hoober, Laura L. Eggink, Robert Cote   +2 more
doaj   +1 more source