Results 111 to 120 of about 836,416 (221)

tcrLM: a lightweight protein language model for predicting T cell receptor and epitope binding specificity [PDF]

arXiv
The anti-cancer immune response relies on the bindings between T-cell receptors (TCRs) and antigens, which elicits adaptive immunity to eliminate tumor cells. This ability of the immune system to respond to novel various neoantigens arises from the immense diversity of TCR repository.
arxiv  

Understanding the role of B-cells in CAR T-cell therapy in leukemia through a mathematical model [PDF]

arXiv
Chimeric Antigen Receptor T (CAR-T) cell therapy has been proven to be successful against different leukaemias and lymphomas. This paper makes an analytical and numerical study of a mathematical model describing the competition of CAR-T, leukaemias tumor and B cells.
arxiv  

Chimeric antigen receptor T-cell therapy [PDF]

Indian Journal of Medical and Paediatric Oncology, 2020
Azgar Abdul Rasheed, Venkata Pradeep Babu Koyyala   +1 more
openaire   +1 more source

TCR-GPT: Integrating Autoregressive Model and Reinforcement Learning for T-Cell Receptor Repertoires Generation [PDF]

arXiv
T-cell receptors (TCRs) play a crucial role in the immune system by recognizing and binding to specific antigens presented by infected or cancerous cells. Understanding the sequence patterns of TCRs is essential for developing targeted immune therapies and designing effective vaccines.
arxiv  

ATLAS-seq: a microfluidic single-cell TCR screen for antigen-reactive TCRs

Nature Communications
Discovering antigen-reactive T cell receptors (TCRs) is central to developing effective engineered T cell immunotherapies. However, the conventional technologies for isolating antigen-reactive TCRs (i.e., major histocompatibility complex (MHC) multimer ...
Siwei Luo, Amber Notaro, Lan Lin
doaj   +1 more source

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

Nature Network Boston, 2018
J. Fraietta, S. Lacey, Elena J Orlando, Iulian Pruteanu-Malinici, M. Gohil, Stefan Lundh, A. Boesteanu, Yan Wang, Roddy S. O’Connor, W. Hwang, E. Pequignot, David E. Ambrose, Changfeng Zhang, Nicholas Wilcox, F. Bedoya, C. Dorfmeier, Fang Chen, Lifeng Tian, Harit Parakandi, Minnal Gupta, R. Young, F. B. Johnson, I. Kulikovskaya, Li Liu, Jun Xu, Sadik H. Kassim, M. Davis, B. Levine, N. Frey, D. Siegel, Alexander C. Huang, E. Wherry, H. Bitter, J. Brogdon, D. Porter, C. June, J. Melenhorst   +36 more
semanticscholar   +1 more source

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

Nature, 2019
Mohamad Hamieh, Anton Dobrin, Annalisa Cabriolu, Sjoukje J. C. van der Stegen, Theodoros Giavridis, J. Mansilla-Soto, Justin Eyquem, Zeguo Zhao, Benjamin Whitlock, Matthew M. Miele, Zhuoning Li, K. Cunanan, M. Huse, R. Hendrickson, Xiuyan Wang, I. Rivière, M. Sadelain   +16 more
semanticscholar   +1 more source

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

Nature Immunology, 2013
Linda V. Sinclair, J. Rolf, E. Emslie, Yunbo Shi, P. Taylor, D. Cantrell   +5 more
semanticscholar   +1 more source

Physiological and therapeutic relevance of T cell receptor-mediated antigen trogocytosis

Biomedical Journal
Trogocytosis is an active process whereby fragments of plasma membrane proteins and cytoplasm are transferred from one cell to another in a cell-cell contact-dependent manner. T cells trogocytose pieces of the cells presenting antigen to them at the site
Nuria Martinez-Martin, Balbino Alarcon
doaj  

Management of patients with non-Hodgkin’s lymphoma: focus on adoptive T-cell therapy

ImmunoTargets and Therapy, 2015
Serena Kimi Perna,1 Leslie E Huye,1,† Barbara Savoldo1,2 1Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital, Houston, TX, 2Department of Pediatrics, Texas Children's Hospital, Houston, TX, USA  ...
Perna SK, Huye LE, Savoldo B
doaj