Results 131 to 140 of about 924,854 (308)

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires

, 2019
The adaptive immune system is a natural diagnostic and therapeutic. It recognizes threats earlier than clinical symptoms manifest and neutralizes antigen with exquisite specificity.
Abbas, Adams, Adli, Alipanahi, Alpert, AlQuraishi, Altan-Bonnet, Angeletti, Angermueller, Antunes, Arora, Arora, Arora, Azizi, Ba, Bachmann, Bandeira, Baran, Barlow, Bashford-Rogers, Bashor, Bassani-Sternberg, Bassani-Sternberg, Bassani-Sternberg, Bassing, Baumgarth, Ben-Hamo, Benjamin, Benjamin, Bentzen, Bentzen, Bepler, Bethune, Bhat, Birnbaum, Biswas, Blythe, Bolotin, Bongartz, Boyd, Bradbury, Bradley, Breden, Brenner, Briggs, Briney, Britanova, Broere, Brown, Buenrostro, Bulik-Sullivan, Burnett, Busse, Cao, Carey, Carmona, Carreno, Casadevall, Casini, Chaudhary, Chen, Cheow, Cheung, Chevalier, Ching, Christina Fan, Cinelli, Cobey, Cohen, Cohen, Cole, Corcoran, Correia, Corrie, Croote, Cybenko, Daberdaku, Dash, Davies, Davis, Davis, Davis, De Neuter, Deac, DeKosky, DeKosky, Devilder, Devulapally, DeWitt, DeWitt 3rd, DeWitt III, Dey, Ecker, Egorov, Egorov, EL-Manzalawy, EL-Manzalawy, EL-Manzalawy, Elgundi, Elhanati, Elhanati, Elhanati, Elhanati, Elton, Emerson, Emini, Esteva, Eyer, Farlik, Farmer, Farmer, Fellouse, Ferdous, Fine, Fink, Fischer, Fischman, Fishman, Flower, Fowler, Frank, Friedensohn, Galperin, Galson, Gee, Gee, Geering, Gentiluomo, Georgiev, Georgiou, Gidoni, Gielis, Glanville, Glanville, Goddard, Goldstein, Goodfellow, Goodfellow, Gowthaman, Graf, Greaves, Greenbaum, Greenspan, Greenspan, Greenspan, Greiff, Greiff, Greiff, Greiff, Greiff, Griffiths, Grigaityte, Guo, Guo, Hadrup, Halperin, Han, Han, Hartweger, Hashimshony, Hashimshony, Haynes, He, Heather, Heather, Hebditch, Heemskerk, Hellman, Hillman, Hochgerner, Hochreiter, Hochreiter, Hoehn, Hoehn, Holder, Holland, Holzinger, Hoogenboom, Hopp, Hornik, Hou, Howie, Hua, Huang, Imkeller, Irvine, Ishino, Islam, Islam, Jackson, Jackson, Jacobs, Jacobsen, Jacobsen, Jain, Jain, Jaitin, Janin, Jardine, Jardine, Jeanbart, Jerne, Jespersen, Joglekar, Jokinen, June, Jyothi, Kabat, Kanyavuz, Kaplon, Karplus, Keich, Keskin, Khosravi-Maharlooei, Kieke, Kingma, Kisielow, Klambauer, Klebanoff, Konishi, Korn, Kotzias, Kovaltsuk, Kramer, Krawczyk, Krawczyk, Krawczyk, Kringelum, Kunik, Kunik, Kuroda, Lanchantin, Lanzarotti, Lapidoth, Lapidoth, Laplane, Larsen, Lauer, Lavinder, Lavoie, LeCun, Lee, Lee, Legutki, Legutki, Levitt, Li, Li, Li, Li, Liberis, Lindeman, Linette, Liu, Liu, Liu, Liu, Lollier, Longo, Lu, Luo, Luo, Luo, López-Santibáñez-Jácome, Løset, MacBeath, Macosko, Madi, Madi, Mahajan, Manavalan, Manczinger, Mangul, Mangul, Marchalonis, Marcou, Margalit, Marrack, Marrack, Marrack, Martin, Martin, Mascola, Mason, Mason, Mayer, McDaniel, Meng, Merbl, Meysman, Mian, Migalska, Miho, Miho, Minhas, Moffett, Mohan, Mora, Mora, Murphy, Murugan, Muyldermans, Navalkar, Nemazee, Newell, Newell, Newell, Nimrod, North, Oakes, Ohlin, Olson, Ostmeyer, Ostmeyer, Ott, Ott, Padlan, Palme, Parker, Parola, Patterson, Pellequer, Perelson, Perelson, Persson, Peterson, Picelli, Pierce, Pittala, Pogorelyy, Pogorelyy, Pogson, Ponomarenko, Ponomarenko, Pou, Preuer, Priel, Purwada, Purwada, Quang, Radbruch, Ramos-López, Ramsköld, Raybould, Remington, Reshetova, Ribeiro, Richards, Richman, Riley, Rives, Rizzetto, Robert, Robins, Robins, Robinson, Rosati, Rosenberg, Rosenblatt, Rubelt, Rubinstein, Sahin, Saikia, Sandve, Sandve, Sblattero, Schmitt, Schneider, Schneider-Hohendorf, Schroeder, Schumacher, Schwab, Scott, Seet, Segler, Seimetz, Sela-Culang, Sela-Culang, Sela-Culang, Sethna, Sethna, Setliff, Sette, Sewell, Shah, Shalev-Shwartz, Sharon, Shaw, Shokri, Shugay, Shugay, Sidhom, Sidhom, Sikorski, Simonovsky, Simonyan, Sircar, Sircar, Slocombe, Smallwood, Soto, Spiess, Stoeckius, Stone, Strauli, Stubbington, Stubbington, Sundararajan, Swartz, Sylwester, Szegedy, Tague, Talmage, Tang, Taussig, Thakkar, Thomas, Thomas, Tickotsky, Tiller, Tirosh, Tompa, Tonegawa, Townsend, Trepel, Trolle, Turchaninova, Turner, Udyavar, Vamathevan, van der Schoot, Van Regenmortel, Venturi, Verkoczy, Vollmers, Voss, Vázquez Bernat, Wainberg, Walsh, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wardemann, Wardemann, Wardemann, Watson, Weinstein, Weitzner, Weitzner, Whitehead, Williams, Wine, Wine, Wirth, Woese, Wucherpfennig, Wurch, Xu, Xu, Xu, Yaari, Yaari, Yager, Yang, Younger, Zandian, Zarnitsyna, Zhang, Zhang, Zhao, Zhao, Zhao, Zheng, Zirlik, Zong   +478 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Genome editing iPSC to purposing enhancement of induce CD8 killer T cell function for regenerative immunotherapy

Inflammation and Regeneration
In recent years, immunotherapy has become a standard cancer therapy, joining surgery, chemotherapy, and radiation therapy. This therapeutic approach involves the use of patient-derived antigen-specific T cells or genetically modified T cells engineered ...
Sota Kurihara, Akihiro Ishikawa, Shin Kaneko   +2 more
doaj   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Emerging strategies to target metastasis and therapy resistance in melanoma

Molecular Oncology, EarlyView.
Emerging studies propose new approaches to interfere with melanoma progression. In recognition of melanoma awareness month, at Molecular Oncology, we highlight recently published research articles, focusing on novel therapeutic targets driving metastatic spread and outlining different strategies to overcome resistance to BRAF inhibitors and anti‐PD‐1 ...
Amel Aziba
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Inferring processes underlying B-cell repertoire diversity

, 2015
We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains.
Aleksandra M. Walczak, Curtis G. Callan, Dunn-Walters DK, Janeway C, Quentin Marcou, Shapiro GS, Shiokawa S, Stryer L, Thierry Mora, Yuval Elhanati, Zachary Sethna   +10 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source