Results 131 to 140 of about 15,994,939 (300)

Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

Journal of Experimental Medicine, 2002
To identify endocytic receptors that allow dendritic cells (DCs) to capture and present antigens on major histocompatibility complex (MHC) class I products in vivo, we evaluated DEC-205, which is abundant on DCs in lymphoid tissues.
L. Bonifaz, D. Bonnyay, K. Mahnke, M. Rivera, M. Nussenzweig, R. Steinman   +5 more
semanticscholar   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Application progress on immunotherapy with chimeric antigen receptor T cell in patients with hematological malignancies

Huli yanjiu, 2020
Reviewing application progress on immunotherapy with chimeric antigen receptor T cell（CAR⁃T） in patients with hematological malignancies from 4 aspects,such as collection,pretreatment,note on cell reinfusion,and treatment complication of chimeric antigen
MENG Rui, XU Li, WAN Ying
doaj  

Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases

Journal of Immunology Research, 2019
Chimeric antigen receptor T (CAR-T) cells are T cells engineered to express specific synthetic antigen receptors that can recognize antigens expressed by tumor cells, which after the binding of these antigens to the receptors are eliminated, and have ...
Yuehong Chen, Jianhong Sun, Huan Liu, Geng Yin, Qibing Xie   +4 more
doaj   +1 more source

Nr4a transcription factors limit CAR T cell function in solid tumors

Nature, 2019
T cells expressing chimeric antigen receptors (CAR T cells) targeting human CD19 (hCD19) have shown clinical efficacy against B cell malignancies1,2.
Joyce Chen, Isaac F. López-Moyado, Hyungseok Seo, C. Lio, Laura J. Hempleman, Takashi Sekiya, A. Yoshimura, J. Scott-Browne, A. Rao   +8 more
semanticscholar   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells [PDF]

, 2014
The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK).
Benoit Viollet, David K. Finlay, Doreen A. Cantrell, Finlay David K., Viollet, Benoit, Marc Foretz, Cantrell, Doreen A., Viollet Benoit, FINLAY, DAVID, Marouan Zarrouk, Zarrouk, Marouan, David K Finlay, Doreen A Cantrell, Zarrouk Marouan, Foretz, Marc, Foretz Marc, Cantrell Doreen A., Finlay, David K.   +17 more
core   +1 more source

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

Science Translational Medicine, 2011
Adoptively transferred gene-modified T cells expand in vivo, eliminate leukemic cells, and form functional memory cells in patients. Go CAR-Ts in the Fast Lane As members of the body’s police force, cells of the immune system vigilantly pursue bad actors
M. Kalos, B. Levine, D. Porter, S. Katz, S. Grupp, A. Bagg, C. June   +6 more
semanticscholar   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

Science Translational Medicine, 2014
CD19 CAR T cell therapy induces complete remissions in 88% of 16 adult patients with relapsed or refractory acute lymphoblastic leukemia. CARving Out a Niche for CAR T Cell Immunotherapy Relapsed or refractory B acute lymphoblastic leukemia (B-ALL) in ...
M. Davila, I. Rivière, Xiu-Yan Wang, S. Bartido, Jae H. Park, K. Curran, Stephen S. Chung, J. Stefanski, Oriana Bórquez-Ojeda, M. Olszewska, Jinrong Qu, Teresa Wasielewska, Q. He, Mitsú J. Fink, Himaly Shinglot, M. Youssif, M. Satter, Yongzeng Wang, James Hosey, Hilda Quintanilla, E. Halton, Yvette Bernal, Diana C. G. Bouhassira, M. Arcila, M. Gonen, G. Roboz, P. Maslak, Dou-Er Dan, M. Frattini, S. Giralt, M. Sadelain, R. Brentjens   +31 more
semanticscholar   +1 more source