Results 191 to 200 of about 836,416 (221)
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Antigen Recognition Determinants of γδ T Cell Receptors
Science, 2005The molecular basis of γδ T cell receptor (TCR) recognition is poorly understood. Here, we analyze the TCR sequences of a natural γδ T cell population specific for the major histocompatibility complex class Ib molecule T22.
Sunny Shin +6 more
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Antibodies to T cell receptors and to histocompatibility antigens
Cellular Immunology, 1974Abstract The injection of 10 6 parental strain spleen cells into adult F1 hybrid mice resulted in the formation of two serum activities: anti-receptor antibodies and alloantibodies. To demonstrate the respective roles of T and B cells in the elicitation of these serum activities, parental strain lymphoid cell suspensions containing varying ...
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Advances in chimeric antigen receptor T cells
Current Opinion in Hematology, 2020Purpose of review To discuss the important advances in CAR T cell therapy over the past year, focusing on clinical results where available. Recent findings Approximately 30 years after they were first conceived of and 15 years after the first small-scale single-center clinical ...
Saar Gill, Ofrat Beyar-Katz
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Kawasaki Disease and the T-Cell Antigen Receptor
Human Immunology, 1998We investigated the evidence for an infectious etiology of Kawasaki disease (KD), an acute vasculitis of unknown etiology, by assessing the effects of KD on the T cell antigen receptor variable beta region families (V beta). Using 3-color flow cytometry, we studied KD patients pre- and post-intravenous gamma globulin (IVIG) therapy and at > 40 days ...
M Seidman +5 more
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The B-cell antigen receptor complex
Immunology Today, 1991Abstract Here, Michael Reth, John Cambier and colleagues review the genetics, biochemistry and cell biology o f the recently-identified accessory components o f the B-cell antigen receptor.
Kerry S. Campbell +6 more
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1982
Initiation of the immune response following antigenic challenge begins with the specific interaction of epitopes on the antigen- and plasma membrane-associated receptors found on the cell surface of lymphocytes. Certainly the interaction of antigen with both regulatory and effector thymus-derived lymphocytes (T cells) is a critical event in this ...
Michael A Harvey, Albert August Luderer
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Initiation of the immune response following antigenic challenge begins with the specific interaction of epitopes on the antigen- and plasma membrane-associated receptors found on the cell surface of lymphocytes. Certainly the interaction of antigen with both regulatory and effector thymus-derived lymphocytes (T cells) is a critical event in this ...
Michael A Harvey, Albert August Luderer
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Multimolecular associations of the T-cell antigen receptor
Trends in Cell Biology, 1992T cells are activated when the T-cell receptor for antigen (TCR) interacts with an antigenic peptide bound to a major histocompatibility complex (MHC) molecule on the surface of another cell. It is often assumed that T-cell activation is induced by the crosslinking of TCRs.
Alan F. Williams +2 more
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Function of the Antigen Receptor in T Cell Activation
1988The studies described here, including ours and those of others, were aimed at understanding the mechanism(s) by which the T cell antigen receptor transmits signals that result in expression of lymphokine genes. They have focused both on the proximal molecules and biochemical events that account for transmembrane signalling, as well as on the more ...
Arthur Weiss, Mark A. Goldsmith
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Chimeric antigen receptor T-cell toxicity
Current Opinion in Pediatrics, 2019Purpose of review Chimeric antigen receptor -(CAR) T-cell therapy has become a commonly used immunotherapy originally used in the treatment of B-cell leukemias but which are now applied broadly across tumor classes. Although high rates of remission are associated with CAR T-cell therapy, toxicities associated with these novel ...
Edward W. Boyer, Da’Marcus E. Baymon
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The T cell antigen receptor: “The Hunting of the Snark” [PDF]
European Journal of Immunology, 2007 The quest to clone the genes encoding the T cell antigen receptor (TCR) was a tale akin to Lewis Carroll's "The Hunting of the Snark". After a long and often frustrating search, back-to-back papers reporting the discovery of the genes encoding the mouse and human TCR were finally published in the March 8, 1984 edition of Nature.
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