Results 21 to 30 of about 4,036 (179)

Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice. [PDF]

PLoS ONE, 2013
Pruritus (itch) is a severe side effect associated with the use of drugs as well as hepatic and hematological disorders. Previous studies in rodents suggest that bombesin receptor subtypes i.e.
Devki D Sukhtankar, Mei-Chuan Ko
doaj   +1 more source

Bombesin analogue-mediated delivery preferentially enhances the cytotoxicity of a mitochondria-disrupting peptide in tumor cells. [PDF]

PLoS ONE, 2013
Tumor-homing peptides that recognize specific markers on tumor cells have shown potential as drug carriers for targeted cancer therapy. Bombesin receptors are frequently overexpressed or ectopically expressed in a wide range of human tumors. Bombesin and
Hao Yang, Huawei Cai, Lin Wan, Shan Liu, Shengfu Li, Jingqiu Cheng, Xiaofeng Lu   +6 more
doaj   +1 more source

Transcriptomes of electrophysiologically recorded Dbx1-derived respiratory neurons of the preBötzinger complex in neonatal mice

Scientific Reports, 2022
Breathing depends on interneurons in the preBötzinger complex (preBötC) derived from Dbx1-expressing precursors. Here we investigate whether rhythm- and pattern-generating functions reside in discrete classes of Dbx1 preBötC neurons.
Prajkta S. Kallurkar, Maria Cristina D. Picardo, Yae K. Sugimura, Margaret S. Saha, Gregory D. Conradi Smith, Christopher A. Del Negro   +5 more
doaj   +1 more source

Hemorphins Targeting G Protein-Coupled Receptors

Pharmaceuticals, 2021
Hemorphins are short peptides produced by the proteolysis of the beta subunit of hemoglobin. These peptides have diverse physiological effects especially in the nervous and the renin-angiotensin systems.
Mohammed Akli Ayoub, Ranjit Vijayan
doaj   +1 more source

Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors. [PDF]

PLoS ONE, 2015
Identification of cognate ligands for G protein-coupled receptors (GPCRs) provides a starting point for understanding novel regulatory mechanisms. Although GPCR ligands have typically been evaluated through the activation of heterotrimeric G proteins ...
Yuichi Ikeda, Hidetoshi Kumagai, Hiroaki Okazaki, Mitsuhiro Fujishiro, Yoshihiro Motozawa, Seitaro Nomura, Norifumi Takeda, Haruhiro Toko, Eiki Takimoto, Hiroshi Akazawa, Hiroyuki Morita, Jun-ichi Suzuki, Tsutomu Yamazaki, Issei Komuro, Masashi Yanagisawa   +14 more
doaj   +1 more source

Intraluminal chloride regulates lung branching morphogenesis: involvement of PIEZO1/PIEZO2

Respiratory Research, 2023
Background Clinical and experimental evidence shows lung fluid volume as a modulator of fetal lung growth with important value in treating fetal lung hypoplasia.
Ana N. Gonçalves, Rute S. Moura, Jorge Correia-Pinto, Cristina Nogueira-Silva   +3 more
doaj   +1 more source

Pharmacological Effects of Two Novel Bombesin-Like Peptides from the Skin Secretions of Chinese Piebald Odorous Frog (Odorrana schmackeri) and European Edible Frog (Pelophylax kl. esculentus) on Smooth Muscle

Molecules, 2017
Bombesin-like peptides, which were identified from a diversity of amphibian skin secretions, have been demonstrated to possess several biological functions such as stimulation of smooth muscle contraction and regulation of food intake.
Xiaowei Zhou, Chengbang Ma, Mei Zhou, Yuning Zhang, Xinping Xi, Ruimin Zhong, Tianbao Chen, Chris Shaw, Lei Wang   +8 more
doaj   +1 more source

Stimulatory and Inhibitory Roles of Brain 2-Arachidonoylglycerol in Bombesin-Induced Central Activation of Adrenomedullary Outflow in Rats

Journal of Pharmacological Sciences, 2013
2-Arachidonoylglycerol (2-AG) is recognized as a potent endocannabinoid, which reduces synaptic transmission through cannabinoid CB1 receptors, and is hydrolyzed by monoacylglycerol lipase (MGL) to arachidonic acid (AA), a cyclooxygenase substrate.
Takahiro Shimizu, Kenjiro Tanaka, Kunihiko Yokotani   +2 more
doaj   +1 more source

Overexpression of Gastrin-Releasing Peptide Receptors in Tumor-Associated Blood Vessels of Human Ovarian Neoplasms

Cellular Oncology, 2007
Background: Peptide receptors, overexpressed in specific cancers, represent new diagnostic and therapeutic targets. In this study, receptors for the gastrin-releasing peptide (GRP), and other members of the bombesin-family of peptides, were evaluated in ...
Achim Fleischmann, Beatrice Waser, Jean Claude Reubi   +2 more
doaj   +1 more source

Comparison of two peptide radiotracers for prostate carcinoma targeting

Clinics, 2012
OBJECTIVES: Scintigraphy is generally not the first choice treatment for prostate cancer, although successful studies using bombesin analog radiopeptides have been performed.
Bluma Linkowski Faintuch, Erica A. Oliveira, Eutimio G. F. Nunez, Ana M. Moro, P. K. Nanda, Charles J. Smith   +5 more
doaj   +1 more source