Results 41 to 50 of about 4,036 (179)
Chemistry – A European Journal, Volume 32, Issue 25, 2 July 2026.A phosphorescent iridium(III) complex has been prepared with a 6‐hydrazinonicotinic acid (HYNIC) ligand tethered to a lysine‐ureido‐glutamatic acid pharmacophore, which binds to an enzyme, called prostate‐specific membrane antigen (PSMA), which is overexpressed in prostate cancer.
La'El Kimchi +6 more
wiley +1 more source
Evolution of bombesin conjugates for targeted PET imaging of tumors. [PDF]
PLoS ONE, 2012 Bombesin receptors are under intense investigation as molecular targets since they are overexpressed in several prevalent solid tumors. We rationally designed and synthesized a series of modified bombesin (BN) peptide analogs to study the influence of ...
Hanwen Zhang +7 more
doaj +1 more source
Self‐Immolative Systems in Diagnostic and Therapeutic Applications
ChemMedChem, Volume 21, Issue 5, 13 March 2026.Self‐Immolative Systems enable the precise, residue‐free release of active molecules, drugs, probes, or sensors, via cyclization or elimination, triggered by specific stimuli. Their versatility drives advances in drug delivery, diagnostics, nanotechnology, materials chemistry, and biosensing, offering chemists control over molecular activation and ...
Windbedema Prisca Ouédraogo +2 more
wiley +1 more source
Medical Physics, Volume 53, Issue 3, March 2026.Abstract Background Associated normal tissue toxicity from current radiotherapy (RT) treatments limits effective dose escalation in the tumor to achieve nominal treatment results. Gold nanoparticles (GNPs) as radiosensitizing agents to locally increase photoelectron production have gained interest as a safe and viable method to improve therapeutic ...
Daniel Cecchi +6 more
wiley +1 more source
Frontiers in Endocrinology, 2012 There are many orphan G-protein-coupled receptors (GPCRs) for which ligands have not yet been identified. One such GPCR is the bombesin receptor subtype 3 (BRS-3). BRS-3 plays a role in the onset of diabetes and obesity.
Takanori eIda +17 more
doaj +1 more source
New Insights into the Stereochemical Requirements of the Bombesin BB1 Receptor Antagonists Binding
Pharmaceuticals, 2020 Members of the family of bombesinlike peptides exert a wide range of biological activities both at the central nervous system and in peripheral tissues through at least three G-Protein Coupled Receptors: BB1, BB2 and BB3.
Bahareh Rasaeifar +2 more
doaj +1 more source
Potential Targets and Biomarkers of Radionuclide Therapy in Breast Cancer
Cancer Innovation, Volume 5, Issue 1, February 2026.Potential biomarkers for the development of targeted radionuclide therapy that can be employed in the treatment of breast cancer have been summarised in the review. They include receptor markers of ER, PR and HER2, as well as other markers of Trop2, PD‐1, EGFR, GRPR and PSMA.
Yujing Tan +3 more
wiley +1 more source
Molecules, 2017 Many synthetic peptides have been developed for diagnosis and therapy of human cancers based on their ability to target specific receptors on cancer cell surface or to penetrate the cell membrane.
Anna Lucia Tornesello +3 more
doaj +1 more source
Role of Opioid Receptors in Bombesin‐induced Groominga [PDF]
Annals of the New York Academy of Sciences, 1988 Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/73648/1/j.1749-6632.1988.tb38614.x ...
Gmerek, Debra E., Cowan, Alan
openaire +3 more sources
Bioorthogonal Chemistry in Biomolecule Quantification: A Review of Reactions and Strategies
Chemistry – A European Journal, Volume 32, Issue 1, 2 January 2026.This review summarizes the application of catalyst‐free bioorthogonal reactions: Staudinger ligation, strain promoted azide alkyne cycloaddition, inverse electron‐demand Diels–Alder, and 2‐cyanobenzothiazole cysteine condensation in the semi‐quantitative and quantitative analysis of biomolecules.
Mingze Yang, Shiqi Wang
wiley +1 more source