Results 61 to 70 of about 4,036 (179)

Ultrasmall Superparamagnetic Iron Oxide Nanoparticles as Positive Contrast Agents in Low‐Field Magnetic Resonance Imaging

iRADIOLOGY, Volume 3, Issue 5, Page 372-387, October 2025.
Ultrasmall superparamagnetic iron oxide nanoparticles emerge as promising positive contrast agents for low‐field MRI. Unlike larger SPIONs, these particles exhibit enhanced T1 relaxivity through rapid magnetic fluctuations and surface spin canting. Their biocompatibility, renal clearance pathway, and bright contrast generation offer safer alternatives ...
Ogechukwu Ngwu‐Hyacinth, Aaron Alford, Caleb S. Rowe, Ryan Willoughby, S. Abdollah Mirbozorgi, Steven A. Rothenberg, Jesse Jones, Abin Sajan, Venkatesh P. Krishnasamy, Mark Bolding   +9 more
wiley   +1 more source

Constitutively active BRS3 is a genuinely orphan GPCR in placental mammals.

PLoS Biology, 2019
G protein-coupled receptors (GPCRs) play an important role in physiology and disease and represent the most productive drug targets. Orphan GPCRs, with their endogenous ligands unknown, were considered a source of drug targets and consequently attract ...
Huihao Tang, Chuanjun Shu, Haidi Chen, Xiaojing Zhang, Zhuqing Zang, Cheng Deng   +5 more
doaj   +1 more source

Anticancer Molecular Mechanisms of Epigallocatechin Gallate: An Updated Review on Clinical Trials

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Epigallocatechin gallate (EGCG), a bioactive compound abundantly exists in green tea and grapes with strong antioxidant activity and anticancer potential is a suitable approach to reduce the cancer burden. The invitro and invivo anticancer studies of EGCG proved anticancer and anti‐tumor effect through modulation of cancer signaling pathways, reduction
Ahmad Mujtaba Noman, Muhammad Tauseef Sultan, Aimen Mazhar, Iqra Baig, Jawaria Javaid, Muzzamal Hussain, Muhammad Imran, Suliman A. Alsagaby, Waleed Al Abdulmonem, Ahmed Mujtaba, Tadesse Fenta Yehuala, Mohammed M. Ghoneim, Ehab M. Mostafa, Mohamed A. Abdelgawad   +13 more
wiley   +1 more source

Radiolabeled Nanogels: From Multimodality Imaging to Combination Therapy of Cancer

Small Science, Volume 5, Issue 8, August 2025.
Nanogel refers to nanosized particles formed by physical or chemical crosslinking of polymers. Rational design and refinement of nanogel properties are imperative to unlock their full potential, ensuring tailored solutions for personalized cancer management. This review elucidates the transformative potential of radiolabeled nanogels in revolutionizing
Sanchita Ghosh, Weibo Cai, Rubel Chakravarty   +2 more
wiley   +1 more source

Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism

Molecular Metabolism, 2017
Objective: Bombesin-like receptor 3 (BRS-3) is an orphan G protein-coupled receptor. Brs3 null mice have reduced resting metabolic rate and body temperature, increased food intake, and obesity.
Cuiying Xiao, Ramón A. Piñol, Jesse Lea Carlin, Cuiling Li, Chuxia Deng, Oksana Gavrilova, Marc L. Reitman   +6 more
doaj   +1 more source

Updated insights into the molecular pathogenesis of canine atopic dermatitis

Veterinary Dermatology, Volume 36, Issue 4, Page 375-384, August 2025.
Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley   +1 more source

Roles and Impacts of Integrative Medical Interventions in Central Nervous System Tumor Treatment: Multi‐Technology Convergence and the Paradigm Shift Toward Functional Reconstruction

CNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.
Multi‐technology interventions (non‐invasive neuromodulation, AI, 3D organoids) for CNS tumor treatment shift from monotherapy to functional reconstruction. They address BBB restriction, tumor heterogeneity, and immune suppression via biological–psychological–technological convergence, enabling precision oncology through dynamic monitoring and ...
Junda Lai, Ketao Liu, Yuhua Lin, Zhonglin Chen, Xianglun Ji, Junkai Wen   +5 more
wiley   +1 more source

Radiolabeled Peptides: Valuable Tools for the Detection and Treatment of Cancer

Theranostics, 2012
Human cancer cells overexpress many peptide receptors as molecular targets. Radiolabeled peptides that bind with high affinity and specificity to the receptors on tumor cells hold great potential for both diagnostic imaging and targeted radionuclide ...
M. Fani, H. R. Maecke, S. M. Okarvi
doaj  

Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target

Frontiers in Endocrinology, 2012
Neuropeptides acting on specific cell membrane receptors of the G protein-coupled receptor (GPCR) superfamily regulate a range of important aspects of nervous and neuroendocrine function.
Rafael eRoesler, Gilberto eSchwartsmann
doaj   +1 more source

Clinical application of 99mTc‐labeled peptides for tumor imaging: Current status and future directions

iRADIOLOGY
Targeting receptors overexpressed on cancer cells with radiolabeled peptides has become a crucial aspect of molecular imaging in oncology. Small peptides offer favorable characteristics for tumor targeting with minimal side effects and toxicity owing to ...
Jiyun Shi, Shuang Liu
doaj   +1 more source