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Results 91 to 100 of about 21,215 (175)

Berotralstat Tolerability and Effectiveness in Hereditary Angioedema: Berolife Study Results

Clinical and Translational Allergy, Volume 16, Issue 8, August 2026.
ABSTRACT Background Berotralstat is a first‐line once‐daily oral prophylactic treatment for hereditary angioedema (HAE). Berolife was designed to evaluate the tolerability and effectiveness of berotralstat in real‐world conditions. Methods Berolife is an open‐label, multicenter, observational study conducted in France from September 2021 to January ...
Delphine Gobert +26 more
wiley +1 more source

The Effects of Bromelain Supplementation on Clinical Outcomes, Inflammatory and Oxidative Stress Biomarkers in Patients With Traumatic Brain Injury: A Randomized, Double‐Blind Placebo‐Controlled Clinical Trial

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Bromelain supplementation significantly reduced IL‐6 levels (p < 0.001), APACHE scores (p = 0.011), SOFA scores (p < 0.001), and NUTRIC scores (p < 0.001). Furthermore, 60‐day mortality was significantly lower in the Bromelain group compared to the Placebo group (p = 0.036). However, there was no significant effect on CRP (p = 0.377) or MDA levels (p =
Alireza Gheflati +8 more
wiley +1 more source

Pharmacological Assessment of Calamus guruba Methanolic Extract: Multitarget Effects on Diabetes, Inflammation, Anxiety, and Depression

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Calamus guruba Buch.‐Ham. (family Arecaceae) is a highly regarded traditional medicinal plant known for its diverse therapeutic benefits. This research aimed to investigate the antidiabetic, anti‐inflammatory, anxiolytic, and antidepressant effects of the methanolic extract of C. guruba (MECG).
Mohi Uddin +5 more
wiley +1 more source

Biased agonism of G protein-coupled receptors as a novel strategy for osteoarthritis therapy

Bone Research
Osteoarthritis (OA) is a prevalent degenerative joint disorder marked by chronic pain, inflammation, and cartilage loss, with current treatments limited to symptom relief.
Xiangbo Meng, Ling Qin, Xinluan Wang
doaj +1 more source

Integrative GC–MS, FT‐IR, and Molecular Docking Analysis of Drimycarpus racemosus (Roxb.) Hook.f ex Marchand: In Vivo Analgesic and Antidiabetic Potential

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
GC–MS profiling of D. racemosus identified bioactive phytochemicals with promising molecular interactions through docking analysis. The methanolic extract demonstrated significant antinociceptive activity against acetic acid‐ and formalin‐induced pain and exhibited antidiabetic effects in streptozotocin‐induced diabetic Swiss albino mice, supporting ...
Md Sajib Ali +7 more
wiley +1 more source

Outcomes in Recurrent Focal Segmental Glomerulosclerosis Post‐Kidney Transplantation Treated With Therapeutic Plasma Exchange: A Retrospective Cohort Study

Journal of Clinical Apheresis, Volume 41, Issue 4, August 2026.
ABSTRACT Recurrence of focal segmental glomerulosclerosis (FSGS) following kidney transplantation remains a significant cause of allograft loss. Much remains unknown about the efficacy of apheresis treatments and the factors that determine favorable treatment outcomes.
Chimezie Godswill Okwuonu +4 more
wiley +1 more source

International Guideline on the Diagnosis and Management of Pediatric Patients With Hereditary Angioedema

Allergy, Volume 81, Issue 8, Page 2744-2774, August 2026.
ABSTRACT Hereditary angioedema (HAE) with C1 inhibitor deficiency is a rare disease characterized by unpredictable episodes of tissue swelling (angioedema), which, in most cases, occur first under the age of 18 years, and entail a significant burden of disease not only for the patients but also for their families.
Henriette Farkas +128 more
wiley +1 more source

The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria

Allergy, Volume 81, Issue 8, Page 2582-2632, August 2026.
ABSTRACT This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...
Torsten Zuberbier +221 more
wiley +1 more source

Angioedema in Primary Care: Disease Course and Its Relation to ACE Inhibitor Use

International Journal of Dermatology, Volume 65, Issue 9, Page 1910-1912, September 2026.
Reineke Soegiharto +6 more
wiley +1 more source

Switching Long‐Term Prophylaxis to Donidalorsen for Hereditary Angioedema: 1‐Year OASISplus Results

Allergy, Volume 81, Issue 8, Page 2833-2842, August 2026.
This study evaluated the long‐term safety and efficacy of donidalorsen in patients who switched from a long‐term prophylactic treatment (LTP) to donidalorsen with 1‐year outcomes. Patients who switched from LTP to donidalorsen experienced a 67.6% reduction in HAE attack rates over 52 weeks.
Marc A. Riedl +16 more
wiley +1 more source

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