Results 91 to 100 of about 22,571 (209)

Icatibant, an inhibitor of bradykinin receptor 2, for hereditary angioedema attacks: prospective experimental single-cohort study

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Hereditary angioedema (HAE) with C1 inhibitor deficiency manifests as recurrent episodes of edema involving the skin, upper respiratory tract and gastrointestinal tract. It can be lethal due to asphyxia.
Regis Albuquerque Campos, Solange Oliveira Rodrigues Valle, Alfeu Tavares França, Elisabete Cordeiro, Faradiba Sarquis Serpa, Yara Ferreira Mello, Teresinha Malheiros, Eliana Toledo, Elie Mansour, Gustavo Fusaro, Anete Sevciovic Grumach   +10 more
doaj   +1 more source

Airway Risk in Angioedema: Validation of a Clinical Triage Algorithm for ENT Referral

Otolaryngology–Head and Neck Surgery, Volume 175, Issue 4, Page 874-880, October 2026.
Abstract Objective To identify clinical factors associated with laryngeal involvement in patients with angioedema and to validate a triage algorithm for determining the need for nasopharyngoscopic evaluation in the emergency department (ED). Study Design A retrospective review was performed of all patients presenting to the ED with angioedema or ...
Dan Yaniv, Igor Vainer, Dean Dudkiewicz, Aviram Mizrachi, Yaniv Hamzani, Eyal Yosefof, Nadav Granat, Gideon Bachar   +7 more
wiley   +1 more source

Valsartan/Sacubitril induced isolated angioedema of uvula: A case report

Heliyon
Objective: To report a case of drug-induced isolated angioedema secondary to the use of Entresto (Valsartan/Sacubitril). Case summary: A 75-year-old White man presented with swelling of the uvula with a normal tongue shape and gradual onset of speech ...
Maisa A. Nazzal, Abbas Iter, Ameed Q. Dawabsheh, Majd A. Bsharat   +3 more
doaj   +1 more source

Renin-angiotensin and kallikrein-kinin systems in diabetic retinopathy [PDF]

Scripta Medica, 2019
This brief review describes how two complex systems, the renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS), affect the retina.
Igić Rajko
doaj  

A Cohort Study on Incidence and Factors Associated With Adverse Drug Reactions of Enalapril in Lusaka, Zambia

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Angiotensin‐converting enzyme inhibitors (ACEIs) are widely prescribed but are associated with adverse drug reactions (ADR), including angioedema, which is typically reported in 0.1%–0.7%. Data from sub‐Saharan Africa are limited. This study aimed to estimate the incidence and risk factors of enalapril‐associated ADRs in a Zambian cohort, with
Ntemena Yikon'a, Ngosa Mumba, Sarah Pedretti, Helen Hoenck, Jonathan Peter, Owen Ngalamika   +5 more
wiley   +1 more source

The lung is more than an organ of gas exchange: immunocompetency, platelets and implications for drug discovery

British Journal of Pharmacology, Volume 183, Issue 20, Page 5999-6006, October 2026.
Abstract The lungs have for a long time been recognised as having pharmacological significance as a specific organ to modulate the pharmacokinetics of endogenous substances needed to maintain homeostasis. The lungs are therefore the site of action of certain drugs that act on these homeostatic processes, resulting in systemic effects on the ...
Simon C. Pitchford
wiley   +1 more source

Management of acute attacks of hereditary angioedema: potential role of icatibant

Vascular Health and Risk Management, 2010
Hilary J LonghurstDepartment of Immunology, Barts and The London NHS Trust, London, UKAbstract: Icatibant (Firazyr®) is a novel subcutaneous treatment recently licensed in the European Union for acute hereditary angioedema. Hereditary angioedema,
Hilary J Longhurst
doaj  

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, Volume 59, Issue 10, Page 2028-2045, October 2026.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

Bradykinin’s carbamylation as a mechanistic link to impaired wound healing in patients with kidney dysfunction

BMC Biology
Background Uremic impairment of wound healing is a well-established phenomenon, however the etiology of this condition continues to be a medical enigma.
Marta Kaminska, Urszula Kałucka, Janka Babickova, Małgorzata Benedyk-Machaczka, Eleni Skandalou, Melissa M. Grant, Hans-Peter Marti, Piotr Mydel   +7 more
doaj   +1 more source

Biased agonism of G protein-coupled receptors as a novel strategy for osteoarthritis therapy

Bone Research
Osteoarthritis (OA) is a prevalent degenerative joint disorder marked by chronic pain, inflammation, and cartilage loss, with current treatments limited to symptom relief.
Xiangbo Meng, Ling Qin, Xinluan Wang
doaj   +1 more source