Results 81 to 90 of about 21,215 (175)

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, Volume 183, Issue 17, Page 5389-5406, September 2026.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Icatibant, an inhibitor of bradykinin receptor 2, for hereditary angioedema attacks: prospective experimental single-cohort study

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Hereditary angioedema (HAE) with C1 inhibitor deficiency manifests as recurrent episodes of edema involving the skin, upper respiratory tract and gastrointestinal tract. It can be lethal due to asphyxia.
Regis Albuquerque Campos, Solange Oliveira Rodrigues Valle, Alfeu Tavares França, Elisabete Cordeiro, Faradiba Sarquis Serpa, Yara Ferreira Mello, Teresinha Malheiros, Eliana Toledo, Elie Mansour, Gustavo Fusaro, Anete Sevciovic Grumach   +10 more
doaj   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Valsartan/Sacubitril induced isolated angioedema of uvula: A case report

Heliyon
Objective: To report a case of drug-induced isolated angioedema secondary to the use of Entresto (Valsartan/Sacubitril). Case summary: A 75-year-old White man presented with swelling of the uvula with a normal tongue shape and gradual onset of speech ...
Maisa A. Nazzal, Abbas Iter, Ameed Q. Dawabsheh, Majd A. Bsharat   +3 more
doaj   +1 more source

Renin-angiotensin and kallikrein-kinin systems in diabetic retinopathy [PDF]

Scripta Medica, 2019
This brief review describes how two complex systems, the renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS), affect the retina.
Igić Rajko
doaj  

The chemokine receptor‐like fourth extracellular loop of the apelin receptor differentially regulates apelin and elabela binding and signalling

British Journal of Pharmacology, Volume 183, Issue 18, Page 5641-5656, September 2026.
Abstract Background and Purpose Apelin and Elabela are endogenous ligands of the apelin receptor (apelin receptor/APJ), a GPCR involved in cardiovascular regulation and body fluid homeostasis. The human receptor contains a conserved disulfide bridge linking the N‐terminal domain to extracellular loop 3 (ECL3) via Cys19 and Cys281, forming a structural ...
Chloé Bonef, Hela Bouhsine, Carine Huynh, Marion Chaigneau, Steven Dubois, Mikel Garcia‐Marcos, Catherine Llorens‐Cortes, Denis Servent, Philippe Robin, Hervé Nozach, Isabel Alves, Xavier Iturrioz   +11 more
wiley   +1 more source

Airway Intervention in Paediatric Angioedema: A National Analysis of Clinical Predictors and Outcomes

Clinical Otolaryngology, Volume 51, Issue 5, Page 729-735, September 2026.
ABSTRACT Objective To characterize paediatric hospitalizations for angioedema and identify the prevalence and outcomes of airway interventions using a large national database. Methods We performed a cross‐sectional analysis of the Kids' Inpatient Database (2003–2019), including paediatric patients (0–20 years) hospitalized with angioedema identified by
Saharsh Talwar, Aryan Mahajan, Gaurav N. Pathak, Babar K. Rao, Rachel Kaye   +4 more
wiley   +1 more source

Management of acute attacks of hereditary angioedema: potential role of icatibant

Vascular Health and Risk Management, 2010
Hilary J LonghurstDepartment of Immunology, Barts and The London NHS Trust, London, UKAbstract: Icatibant (Firazyr®) is a novel subcutaneous treatment recently licensed in the European Union for acute hereditary angioedema. Hereditary angioedema,
Hilary J Longhurst
doaj  

Bradykinin’s carbamylation as a mechanistic link to impaired wound healing in patients with kidney dysfunction

BMC Biology
Background Uremic impairment of wound healing is a well-established phenomenon, however the etiology of this condition continues to be a medical enigma.
Marta Kaminska, Urszula Kałucka, Janka Babickova, Małgorzata Benedyk-Machaczka, Eleni Skandalou, Melissa M. Grant, Hans-Peter Marti, Piotr Mydel   +7 more
doaj   +1 more source

On the History of Hepatic Vein Catheterization

Liver International, Volume 46, Issue 9, September 2026.
ABSTRACT Hepatic vein catheterization (HVC) in man was first performed 80 years ago in the wake of right‐sided heart catheterization. Several new methods, recognitions and concepts followed, especially the indirect Fick‐method for determination of splanchnic blood flow. Five years passed before pressure measurements were performed and routine HVCs were
Jens Henrik Henriksen, Flemming Bendtsen, Søren Møller   +2 more
wiley   +1 more source