Results 231 to 240 of about 44,035 (314)

Neuroimmune circuits in respiratory pathophysiology: decoding molecular crosstalk for precision therapeutic targeting. [PDF]

Ann Med
Chen Q, Jia N, Liu J, Xu C, Shen Z, Shi S, Wang F, Wang Z.   +7 more
europepmc   +1 more source

Long‐Term Improvements Following Initial Migraine Response in Eptinezumab‐Treated Participants With Migraine for Whom 2–4 Prior Preventive Treatments Have Failed

European Journal of Neurology, Volume 33, Issue 3, March 2026.
This post hoc analysis of data from the DELIVER trial evaluated long‐term maintenance of early ≥ 50% and ≥ 75% migraine response. For both eptinezumab doses (100 or 300 mg), ≥ 50% or ≥ 75% migraine response over Weeks 1–12 or 1–24 was maintained for the entire 72‐week treatment period for many participants.
Jessica Ailani, Messoud Ashina, Susanne F. Awad, Xin Ying Lee, Line Pickering Boserup, Seema Soni‐Brahmbhatt, Bjørn Sperling, Richard B. Lipton   +7 more
wiley   +1 more source

Efficacy of Combined Intra-articular Steroids and Calcitonin Nasal Spray versus Intra-articular Steroids Alone in the Management of Early Frozen Shoulder: A Prospective Study. [PDF]

J Orthop Case Rep
Salaria AK, Sharma GK, Negi R, Singh S.
europepmc   +1 more source

Artificial lipidation of proteins and peptides: from mechanism to clinical applications

The FEBS Journal, Volume 293, Issue 5, Page 1269-1284, March 2026.
Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley   +1 more source

Waning light, waxing pain: The lunar cycle's association with migraine headache occurrence

Headache: The Journal of Head and Face Pain, Volume 66, Issue 3, Page 584-594, March 2026.
Plain Language Summary While migraine headaches can be hard to predict, some patients believe headaches are connected to the moon‘s phases. Our research showed that migraine attacks were 34% more likely to occur during the new moon than during the full moon.
Alexander Yoo, Brendan Keenan, Angeliki Vgontzas, Murray A. Mittleman, Suzanne M. Bertisch, Ron Anafi   +5 more
wiley   +1 more source

Treatment effectiveness of galcanezumab versus traditional oral migraine preventive medications at 3 months: Results from the TRIUMPH study

Headache: The Journal of Head and Face Pain, Volume 66, Issue 3, Page 604-614, March 2026.
Abstract Objective This study assesses the 3‐month effectiveness of the calcitonin gene‐related peptide monoclonal antibody galcanezumab versus traditional oral migraine preventive medications. Background Studies comparing the effectiveness of calcitonin gene‐related peptide monoclonal antibodies versus traditional oral migraine preventive medications ...
Richard B. Lipton, Miguel J. A. Láinez, Zubair Ahmed, Carlos Vallarino, Diego Novick, Maurice Vincent, Lars Viktrup, Rebecca L. Robinson   +7 more
wiley   +1 more source

Comprehensive assessment of erenumab efficacy in participants with high‐frequency episodic migraine with at least one previously failed preventive treatment: The EMBRACE study

Headache: The Journal of Head and Face Pain, Volume 66, Issue 3, Page 658-671, March 2026.
Abstract Objective To evaluate the effect of erenumab treatment beyond monthly migraine days in patients with high‐frequency episodic migraine who did not respond to at least one previous migraine preventive treatment. Background Reduction in monthly migraine days has been the efficacy standard for migraine preventive treatments; however, it does not ...
Gabriel Paiva da Silva Lima, Renata Rao, Gyöngyi Szabó, Sebastian Szklener, Cristina Tassorelli, Marcin Nastaj, Denise E. Chou, Ani C. Khodavirdi, Mahan Chehrenama, Yineng Zhu, Ajay K. Bhatia, David W. Dodick   +11 more
wiley   +1 more source

TRPM3 activation causes CGRP release in trigeminal neurons: Implications for migraine mechanisms

Headache: The Journal of Head and Face Pain, Volume 66, Issue 3, Page 672-687, March 2026.
Abstract Background The transient receptor potential melastatin 3 (TRPM3) ion channel has been implicated in sensory modulation and pain transmission and may contribute to migraine pathophysiology through calcitonin gene‐related peptide (CGRP) release in the trigeminovascular system. This study aimed to investigate TRPM3 activation and its role in CGRP
Philip V. Reducha, Lukas K. S. Nielsen, Mette N. Jensen, Jacob C. A. Edvinsson, Spyridoula Kazantzi, Sofia L. Wæver, Tanja Lylloff, Connar S. J. Westgate, Lars Edvinsson, Kristian A. Haanes   +9 more
wiley   +1 more source

Cannabinoids rescue migraine symptoms caused by central CGRP administration in mice. [PDF]

Cephalalgia
Zorrilla E, Duong TL, Piña CL, Russo AF.   +3 more
europepmc   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source