Results 251 to 260 of about 26,165 (305)

Mechanistic insights into cartilage-sensory nerve crosstalk in osteoarthritis progression. [PDF]

open access: yesJ Orthop Translat
Meng H   +7 more
europepmc   +1 more source

Receptors for calcitonin, calcitonin gene related peptide, amylin, and adrenomedullin

open access: yesCanadian Journal of Physiology and Pharmacology, 1995
Calcitonin, calcitonin gene related peptide, amylin, and adrenomedullin are structurally related polypeptides characterized by a six or seven amino acid ring structure linked by a disulfide bridge and an amidated C-terminus. They exhibit overlapping biological actions as a result of cross-reactivity between the different receptors. In this article, the
Muff R, Born W, Fischer JA
openaire   +4 more sources

Pharmacological characterisation of mouse calcitonin and calcitonin receptor‐like receptors reveals differences compared with human receptors

open access: yesBritish Journal of Pharmacology, 2021
Background and PurposeThe calcitonin (CT) receptor family is complex, comprising two receptors (the CT receptor [CTR] and the CTR‐like receptor [CLR]), three accessory proteins (RAMPs) and multiple endogenous peptides. This family contains several important drug targets, including CGRP, which is targeted by migraine therapeutics.
Michael L. Garelja   +9 more
openaire   +3 more sources

Expression of the calcitonin receptor, calcitonin receptor‐like receptor, and receptor activity modifying proteins during osteoclast differentiation

open access: yesJournal of Cellular Biochemistry, 2008
AbstractThe expressions of the calcitonin receptor (CTR), the calcitonin receptor‐like receptor (CLR), the receptor activity‐modifying proteins (RAMP) 1–3, and of the receptor component protein (RCP) have been studied in mouse bone marrow macrophages (BMM) during osteoclast differentiation, induced by treatment with M‐CSF and RANKL.
Susanne, Granholm   +2 more
openaire   +3 more sources

The role of peptides and receptors of the calcitonin family in the regulation of bone metabolism

open access: yesBone, 2008
The ‘calcitonin family’ is a group of peptide hormones that share structural similarities with calcitonin, and includes calcitonin gene-related peptide (CGRP), amylin, adrenomedullin and adrenomedullin 2 (intermedin).
Dorit Naot
exaly   +2 more sources

Molecular Pharmacology of the Calcitonin Receptor

Receptors and Channels, 2002
The peptide hormone calcitonin is widely used therapeutically in the treatment of bone disorders such as Paget's disease, osteoporosis, and the hypercalcemia of some malignancies. However, emerging evidence suggests the actions of calcitonin via its G protein-coupled receptor, the calcitonin receptor, may not be limited to bone.
Purdue, BW, Tilakaratne, N, Sexton, PM
openaire   +4 more sources

Calcitonin Receptors of Human Osteoclastoma

Hormone and Metabolic Research, 1987
Osteoclast-rich cultures were prepared by disaggregation of osteoclastomas (giant cell tumour of bone) and settlement onto glass or plastic surfaces. Autoradiography using [125I]-salmon calcitonin ([125I]-sCT) revealed specific binding only to multinucleate giant cells (osteoclasts) and a minor population of mononuclear cells.
G C, Nicholson   +7 more
openaire   +5 more sources

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