Well-Differentiated Neuroendocrine Tumors of Lung: A Case Series Supporting the IARC/WHO Common Classification of Neuroendocrine Tumor Nomenclature and Grading. [PDF]
Altun E +3 more
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<i>Porphyromonas gingivalis</i> and pain modulation: a narrative review. [PDF]
Hsu HY, Ko CC, Liu YC.
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Osteoporosis in Patients with Pre-Existing Diabetes Mellitus and in Women with Estrogen Deficiency: A Molecular and Cellular Perspective. [PDF]
Pang CY, Chen LR, Chen KH.
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Mechanistic insights into cartilage-sensory nerve crosstalk in osteoarthritis progression. [PDF]
Meng H +7 more
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Receptors for calcitonin, calcitonin gene related peptide, amylin, and adrenomedullin
Calcitonin, calcitonin gene related peptide, amylin, and adrenomedullin are structurally related polypeptides characterized by a six or seven amino acid ring structure linked by a disulfide bridge and an amidated C-terminus. They exhibit overlapping biological actions as a result of cross-reactivity between the different receptors. In this article, the
Muff R, Born W, Fischer JA
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Background and PurposeThe calcitonin (CT) receptor family is complex, comprising two receptors (the CT receptor [CTR] and the CTR‐like receptor [CLR]), three accessory proteins (RAMPs) and multiple endogenous peptides. This family contains several important drug targets, including CGRP, which is targeted by migraine therapeutics.
Michael L. Garelja +9 more
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AbstractThe expressions of the calcitonin receptor (CTR), the calcitonin receptor‐like receptor (CLR), the receptor activity‐modifying proteins (RAMP) 1–3, and of the receptor component protein (RCP) have been studied in mouse bone marrow macrophages (BMM) during osteoclast differentiation, induced by treatment with M‐CSF and RANKL.
Susanne, Granholm +2 more
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The role of peptides and receptors of the calcitonin family in the regulation of bone metabolism
The ‘calcitonin family’ is a group of peptide hormones that share structural similarities with calcitonin, and includes calcitonin gene-related peptide (CGRP), amylin, adrenomedullin and adrenomedullin 2 (intermedin).
Dorit Naot
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Molecular Pharmacology of the Calcitonin Receptor
Receptors and Channels, 2002The peptide hormone calcitonin is widely used therapeutically in the treatment of bone disorders such as Paget's disease, osteoporosis, and the hypercalcemia of some malignancies. However, emerging evidence suggests the actions of calcitonin via its G protein-coupled receptor, the calcitonin receptor, may not be limited to bone.
Purdue, BW, Tilakaratne, N, Sexton, PM
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Calcitonin Receptors of Human Osteoclastoma
Hormone and Metabolic Research, 1987Osteoclast-rich cultures were prepared by disaggregation of osteoclastomas (giant cell tumour of bone) and settlement onto glass or plastic surfaces. Autoradiography using [125I]-salmon calcitonin ([125I]-sCT) revealed specific binding only to multinucleate giant cells (osteoclasts) and a minor population of mononuclear cells.
G C, Nicholson +7 more
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