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Calcitonin Receptors of Kidney and Bone
Science, 1972Receptors for calcitonin, determined by activation of adenylate cyclase, were found in a distribution among zones of the kidney distinct from that of receptors for parathyroid hormone or vasopressin. Competitive binding studies showed that the receptors for calcitonin are similar in kidney and bone and that their high apparent affinity for salmon ...
S J, Marx, C J, Woodward, G D, Aurbach
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Molecular and Cellular Endocrinology, 1988
T47D cells possess specific calcitonin (CT) receptors and a CT-responsive adenylate cyclase. Internalization of part of their CT receptors has been suggested. At 37 degrees C, bound 125I-labelled salmon CT (sCT) becomes increasingly resistant to acid washing, which can remove surface-bound hormone, thus indicating internalization.
H G, Schneider +4 more
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T47D cells possess specific calcitonin (CT) receptors and a CT-responsive adenylate cyclase. Internalization of part of their CT receptors has been suggested. At 37 degrees C, bound 125I-labelled salmon CT (sCT) becomes increasingly resistant to acid washing, which can remove surface-bound hormone, thus indicating internalization.
H G, Schneider +4 more
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Calcitonin and calcitonin receptors.
Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases, 2012Calcitonin (CT) is a polypeptide hormone with 32 aminoacids syntetized primarily by the thyroid.Several evidences support the existence of nonthyroidal CT like peptide. The CT gene transcript also encodes a distinct peptide known as calcitonin gene related peptide (CGRP) which is a potent vasodilator and responsible for the stimulation of the ...
Masi, Laura, Brandi, Maria Luisa
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Transcriptional regulation of the calcitonin receptor gene
Biochemical Society Transactions, 2002Calcitonin is a 32-amino-acid peptide hormone that is produced by parafollicular cells of the thyroid gland in response to increased levels of extracellular calcium. In this article we review our previous and current research on the transcriptional regulation of the pig and human calcitonin receptor (CTR) gene.
M D, Pondel +4 more
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Identification of Calcitonin Receptors in Human Spermatozoa
The Journal of Clinical Endocrinology & Metabolism, 1987Calcitonin (CT) is a powerful hypocalcemic hormone which regulates calcium balance in cells. The presence of CT and CT receptors has been demonstrated in many extrathyroidal tissues, including the male genital tract. CT immunoreactivity has also been found in human seminal fluid, and an inhibitory effect of salmon CT on human sperm motility in vitro ...
SILVESTRONI, Leopoldo +3 more
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Calcitonin, calcitonin gene-related peptide and renal calcitonin receptors in the Zucker rat.
Bone and mineral, 1989In this study we investigated (a) whether genetically obese Zucker rats exhibit higher levels of calcitonin gene-related peptide (CGRP) in the thyroid and plasma than lean controls, (b) if CGRP, like calcitonin (CT), increases in plasma in response to iv Ca or iv pentagastrin and (c) whether or not renal CT receptors exhibit 'downregulation' in fat ...
P K, Seitz, C W, Cooper
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Renal Receptors for Calcitonin: Coordinate Occurrence with Calcitonin-Activated Adenylate Cyclase
Endocrinology, 1975High affinity binding of 125I-labeled salmon calcitonin ([125I]SCT) and calcitonin-activated adenylate cyclase were detectable in renal plasma membranes from the rat. Addition of 5'-guanylyl-imidodiphosphate lowered the threshold for enzyme activation by peptide hormones.
S J, Marx, G D, Aurbach
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Loss of Calcitonin Binding in Rat Is Not Related to Calcitonin Receptor Gene Abnormality
Biochemical and Biophysical Research Communications, 2001C-cell tumors occur frequently (50%) in old WAG/Rij rats. Interestingly, genetically transmitted loss of CT binding sites in the kidney has also been demonstrated in WAG/Rij rats. To determine if these issues are resulted from mutation of calcitonin receptor (CTR), we analyzed the CTR genomic abnormality in WAG/Rij rat. We demonstrated that both Wistar
M, Nakamura +6 more
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Calcitonin Receptors on Circulating Normal Human Lymphocytes*
The Journal of Clinical Endocrinology & Metabolism, 1990Circulating human lymphocytes possess specific and functional receptors for calcitriol and PTH. We sought to determine if they also possessed receptors for calcitonin (CT), the third classical calciotropic hormone. We isolated blood mononuclear cells from healthy volunteers to separate monocytes, total lymphocytes, and T-lymphocytes; the purity of the ...
Body, Jean-Jacques +5 more
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Photoaffinity labeling of the calcitonin receptor
Pharmacology & Therapeutics, 1987J M, Moseley +3 more
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