Results 11 to 20 of about 18,546 (234)
Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors [PDF]
Frontiers in Molecular Biosciences, 2021 Class B1 G protein-coupled receptors (GPCRs) are important targets for many diseases, including cancer, diabetes, and heart disease. All the approved drugs for this receptor family are peptides that mimic the endogenous activating hormones. An understanding of how agonists bind and activate class B1 GPCRs is fundamental for the development of ...
Giuseppe Deganutti +7 more
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Overview of Calcitonin Gene-Related Peptide and Its Receptor [PDF]
The Scientific World JOURNAL, 2001 Calcitonin Gene-Related Peptide (CGRP), a 37 amino acid peptide identified as the alternately spliced gene product of calcitonin gene, is a sensory neuropeptide with potent cardiovascular effects. CGRP is distributed throughout the central and peripheral nervous systems and possesses diverse biological actions. CGRP has been suggested to play a role in
Nambi Aiyar
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Molecular Metabolism, 2021 Background: Therapies for metabolic diseases are numerous, yet improving insulin sensitivity beyond that induced by weight loss remains challenging. Therefore, search continues for novel treatment candidates that can stimulate insulin sensitivity and ...
Nina Sonne +2 more
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Multi-biological functions of intermedin in diseases
Frontiers in Physiology, 2023 Intermedin (IMD) is a member of the calcitonin gene-related peptide (CGRP)/calcitonin (CT) superfamily, and it is expressed extensively throughout the body.
Zhi Yang +9 more
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Frontiers in Pharmacology, 2022 Signaling through calcitonin gene-related peptide (CGRP) receptors is associated with pain, migraine, and energy expenditure. Small molecule and monoclonal antibody CGRP receptor antagonists that block endogenous CGRP action are in clinical use as anti ...
Aqfan Jamaluddin +13 more
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Calcitonin Gene-Related Peptide Receptor Agonism [PDF]
Circulation, 2017 Article, see p 367 Patients with heart failure experience high rates of hospitalization and death, combined with a poor quality of life. Current treatment is aimed at increasing cardiac contractility, enhancing vasodilation, and preventing maladaptive cardiac remodeling.
Danser, Jan +1 more
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The Journal of Headache and Pain, 2021 Background The topical inflammatory soup can model the inflammation of the dura mater causing hypersensitivity and activation of the trigeminal system, a phenomenon present in migraineurs.
Eleonóra Spekker +7 more
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Calcitonin gene-related peptide (CGRP) receptors are important to maintain cerebrovascular reactivity in chronic hypertension. [PDF]
PLoS ONE, 2015 Cerebral blood flow autoregulation (CA) shifts to higher blood pressures in chronic hypertensive patients, which increases their risk for brain damage. Although cerebral vascular smooth muscle cells express the potent vasodilatatory peptides calcitonin ...
Zhenghui Wang +6 more
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Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations
International Journal of Endocrinology, 2020 Calcitonin was discovered as a peptide hormone that was known to reduce the calcium levels in the systemic circulation. This hypocalcemic effect is produced due to multiple reasons such as inhibition of bone resorption or suppression of calcium release ...
Jingbo Xie +9 more
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Role of serotonergic dorsal raphe neurons in hypercapnia-induced arousals
Nature Communications, 2020 Dorsal raphe 5HT(DRSert) neurons regulate arousal from hypercapnia by their projections to the neurons in the external lateral parabrachial nucleus (PBel) that are glutamatergic and also express calcitonin gene related peptide (PBelCGRP).
Satvinder Kaur +10 more
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