Results 21 to 30 of about 18,546 (234)
Molecular Pain, 2016 Background On trigeminal ganglion neurons, pain-sensing P2X3 receptors are constitutively inhibited by brain natriuretic peptide via its natriuretic peptide receptor-A. This inhibition is associated with increased P2X3 serine phosphorylation and receptor
Anna Marchenkova PhD +4 more
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Perampanel inhibits calcitonin gene-related peptide release from rat brainstem in vitro
The Journal of Headache and Pain, 2018 Background Perampanel is a novel antiepileptic drug acting via non-competitive antagonism on glutamatergic AMPA receptors, and the subsequent inhibition of ion calcium influx.
Giuseppe Tringali +2 more
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Calcitonin gene‐related peptide receptors in human gastrointestinal epithelia [PDF]
British Journal of Pharmacology, 1994 The secretory responses to calcitonin gene‐related peptide (CGRP) receptor agonists have been characterized in two human adenocarcinoma cell lines, namely HCA‐7 and Colony‐29 (Col‐29) epithelia. These cells form polarized epithelial layers when grown on permeable supports and allow changes in electrogenic ion transport in response to agonists to be ...
H M, Cox, I R, Tough
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Current overview of the role of neuropeptides in ILC2s and future directions
Allergology International, 2022 The neural and immune systems are closely connected, and recently, their molecular mechanisms and relationships with diseases have attracted substantial attention. Particularly, it has been increasingly reported that ILC2s, which produce type 2 cytokines
Misato Irie +3 more
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CGRP Receptor Family and Accessory Protein Localization: Implications for Predicted Function
The Scientific World Journal, 2001 Calcitonin gene-related peptide (CGRP), adrenomedullin, amylin, and calcitonin are functionally related neuropeptides. Certain of these peptides mediate their action through receptors which have common components, such as the receptor activity modifying ...
K.R. Oliver
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A Native PAGE Assay for the Biochemical Characterization of G Protein Coupling to GPCRs
Bio-Protocol, 2021 G protein-coupled receptors (GPCRs) are a large family of membrane-embedded receptors that have diverse roles in physiology and are major drug targets. GPCRs transduce an agonist binding signal across the membrane to activate intracellular heterotrimeric
Amanda Roehrkasse +2 more
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Recent advances in targeting calcitonin gene-related peptide for the treatment of menstrual migraine
Medicine, 2022 . Menstrual migraine (MM) has a longer duration and higher drug resistance than non-perimenstrual migraine. Calcitonin gene-related peptide (CGRP) and CGRP receptors are expressed in the peripheral and central nervous systems throughout the ...
Yan Jiang, MMed, Zhen-Lun Huang, BMed
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The Scientific World Journal, 2001 CGRP, AM, amylin, and CT have in common N-terminal 6-7 amino acid ring structures linked by disulfide bridges and amidated C-termini required for biological activity.
J.A. Fischer, W. Born, R. Muff
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IBRO Neuroscience Reports, 2022 The trigeminal ganglion is implicated in the underlying pathology of migraine and temporomandibular joint disorders (TMD), which are orofacial pain conditions involving peripheral and central sensitization.
Sophia R. Antonopoulos, Paul L. Durham
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Antagonism of CGRP Signaling by Rimegepant at Two Receptors
Frontiers in Pharmacology, 2020 The “gepants” are a class of calcitonin gene-related peptide (CGRP) receptor antagonist molecules that have been developed for the prevention and treatment of migraine.
Kylie S. Pan +8 more
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