Results 21 to 30 of about 12,370,091 (268)
Renal mesangium is a target for calcitonin gene-related peptide [PDF]
, 1989 Rat calcitonin gene-related peptide (CGRP alpha; EC50, 1 nM) was shown to stimulate cAMP formation in cultured rat renal mesangial cells. CGRP concentration dependently (EC50, 1 nM) also inhibited contraction of mesangial cells by angiotensin II (10 nM).
Schurek, H. J. +29 more
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Perampanel inhibits calcitonin gene-related peptide release from rat brainstem in vitro
The Journal of Headache and Pain, 2018 Background Perampanel is a novel antiepileptic drug acting via non-competitive antagonism on glutamatergic AMPA receptors, and the subsequent inhibition of ion calcium influx.
Giuseppe Tringali +2 more
doaj +1 more source
CGRP Receptor Family and Accessory Protein Localization: Implications for Predicted Function
The Scientific World Journal, 2001 Calcitonin gene-related peptide (CGRP), adrenomedullin, amylin, and calcitonin are functionally related neuropeptides. Certain of these peptides mediate their action through receptors which have common components, such as the receptor activity modifying ...
K.R. Oliver
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The Scientific World Journal, 2001 CGRP, AM, amylin, and CT have in common N-terminal 6-7 amino acid ring structures linked by disulfide bridges and amidated C-termini required for biological activity.
J.A. Fischer, W. Born, R. Muff
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Current overview of the role of neuropeptides in ILC2s and future directions
Allergology International, 2022 The neural and immune systems are closely connected, and recently, their molecular mechanisms and relationships with diseases have attracted substantial attention. Particularly, it has been increasingly reported that ILC2s, which produce type 2 cytokines
Misato Irie +3 more
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A Native PAGE Assay for the Biochemical Characterization of G Protein Coupling to GPCRs
Bio-Protocol, 2021 G protein-coupled receptors (GPCRs) are a large family of membrane-embedded receptors that have diverse roles in physiology and are major drug targets. GPCRs transduce an agonist binding signal across the membrane to activate intracellular heterotrimeric
Amanda Roehrkasse +2 more
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Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies [PDF]
, 2012 Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a
Poyner, David +16 more
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PLoS ONE, 2016 Members of the calcitonin peptide family-calcitonin gene-related peptide (CGRP), adrenomedullin (AM), and adrenomedullin2/intermedin (IMD)-exert modulatory effects upon monocytes and macrophages of various extrapulmonary origins.
Aichurek Soultanova +4 more
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Recent advances in targeting calcitonin gene-related peptide for the treatment of menstrual migraine
Medicine, 2022 . Menstrual migraine (MM) has a longer duration and higher drug resistance than non-perimenstrual migraine. Calcitonin gene-related peptide (CGRP) and CGRP receptors are expressed in the peripheral and central nervous systems throughout the ...
Yan Jiang, MMed, Zhen-Lun Huang, BMed
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Antagonism of CGRP Signaling by Rimegepant at Two Receptors
Frontiers in Pharmacology, 2020 The “gepants” are a class of calcitonin gene-related peptide (CGRP) receptor antagonist molecules that have been developed for the prevention and treatment of migraine.
Kylie S. Pan +8 more
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