Results 31 to 40 of about 12,370,091 (268)
IBRO Neuroscience Reports, 2022 The trigeminal ganglion is implicated in the underlying pathology of migraine and temporomandibular joint disorders (TMD), which are orofacial pain conditions involving peripheral and central sensitization.
Sophia R. Antonopoulos, Paul L. Durham
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Isolation and characterisation of a human calcitonin‐gene‐related‐peptide receptor [PDF]
European Journal of Biochemistry, 1987 We describe the identification and purification of a receptor for calcitonin‐gene‐related peptide (CGRP) from human term placenta, using lectin and β‐CGRP–Affigel affinity chromatography. The membrane‐bound receptor has an estimated Mr of 240000, as determined by cross‐linking 125I‐labelled α‐CGRP (125I‐α‐CGRP) using discuccinimidyl suberate and SDS ...
S M, Foord, R K, Craig
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Neuroendocrinology of the lung revealed by single-cell RNA sequencing
eLife, 2022 Pulmonary neuroendocrine cells (PNECs) are sensory epithelial cells that transmit airway status to the brain via sensory neurons and locally via calcitonin gene-related peptide (CGRP) and γ- aminobutyric acid (GABA).
Christin S Kuo +7 more
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Neuropeptides and the Nodes of Ranvier in Cranial Headaches
Frontiers in Physiology, 2022 The trigeminovascular system (TGV) comprise of the trigeminal ganglion with neurons and satellite glial cells, with sensory unmyelinated C-fibers and myelinated Aδ-fibers picking up information from different parts of the head and sending signals to the ...
Jacob C. A. Edvinsson +4 more
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Botulinum Toxin as a Pain Killer: Players and Actions in Antinociception
Toxins, 2015 Botulinum neurotoxins (BoNTs) have been widely used to treat a variety of clinical ailments associated with pain. The inhibitory action of BoNTs on synaptic vesicle fusion blocks the releases of various pain-modulating neurotransmitters, including ...
Dong-Wan Kim +2 more
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Neuroimmune communication in allergic rhinitis
Frontiers in Neurology, 2023 The prevalence rate of allergic rhinitis (AR) is high worldwide. The inhalation of allergens induces AR, which is an immunoglobulin E-mediated and type 2 inflammation-driven disease.
Yi Zhou +7 more
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, 2023 The roles played by the peptides belonging to the tachykinin (neurokinin A and B) and calcitonin/calcitonin gene-related peptide (adrenomedullin, adrenomedullin 2, amylin, and calcitonin gene-related peptide (CGRP)) peptide families in cancer development
Rafael Coveñas +5 more
core +1 more source
Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration
Advanced Healthcare Materials, EarlyView.This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu +4 more
wiley +1 more source
A second trigeminal CGRP receptor: function and expression of the AMY1 receptor
Annals of Clinical and Translational Neurology, 2015 Objective The trigeminovascular system plays a central role in migraine, a condition in need of new treatments. The neuropeptide, calcitonin gene‐related peptide (CGRP), is proposed as causative in migraine and is the subject of intensive drug discovery ...
Christopher S. Walker +9 more
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Advanced Science, EarlyView.This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan +6 more
wiley +1 more source