Results 31 to 40 of about 18,546 (234)
Neuroendocrinology of the lung revealed by single-cell RNA sequencing
eLife, 2022 Pulmonary neuroendocrine cells (PNECs) are sensory epithelial cells that transmit airway status to the brain via sensory neurons and locally via calcitonin gene-related peptide (CGRP) and γ- aminobutyric acid (GABA).
Christin S Kuo +7 more
doaj +1 more source
PLoS ONE, 2016 Members of the calcitonin peptide family-calcitonin gene-related peptide (CGRP), adrenomedullin (AM), and adrenomedullin2/intermedin (IMD)-exert modulatory effects upon monocytes and macrophages of various extrapulmonary origins.
Aichurek Soultanova +4 more
doaj +1 more source
Neuropeptides and the Nodes of Ranvier in Cranial Headaches
Frontiers in Physiology, 2022 The trigeminovascular system (TGV) comprise of the trigeminal ganglion with neurons and satellite glial cells, with sensory unmyelinated C-fibers and myelinated Aδ-fibers picking up information from different parts of the head and sending signals to the ...
Jacob C. A. Edvinsson +4 more
doaj +1 more source
Isolation and characterisation of a human calcitonin‐gene‐related‐peptide receptor [PDF]
European Journal of Biochemistry, 1987 We describe the identification and purification of a receptor for calcitonin‐gene‐related peptide (CGRP) from human term placenta, using lectin and β‐CGRP–Affigel affinity chromatography. The membrane‐bound receptor has an estimated Mr of 240000, as determined by cross‐linking 125I‐labelled α‐CGRP (125I‐α‐CGRP) using discuccinimidyl suberate and SDS ...
S M, Foord, R K, Craig
openaire +2 more sources
Neuroimmune communication in allergic rhinitis
Frontiers in Neurology, 2023 The prevalence rate of allergic rhinitis (AR) is high worldwide. The inhalation of allergens induces AR, which is an immunoglobulin E-mediated and type 2 inflammation-driven disease.
Yi Zhou +7 more
doaj +1 more source
Botulinum Toxin as a Pain Killer: Players and Actions in Antinociception
Toxins, 2015 Botulinum neurotoxins (BoNTs) have been widely used to treat a variety of clinical ailments associated with pain. The inhibitory action of BoNTs on synaptic vesicle fusion blocks the releases of various pain-modulating neurotransmitters, including ...
Dong-Wan Kim +2 more
doaj +1 more source
Biomolecules, 2022 An inflammatory response following dental pulp injury and/or infection often leads to neurogenic inflammation via the axon reflex. However, the detailed mechanism underlying the occurrence of the axon reflex in the dental pulp remains unclear.
Natsuki Saito +4 more
doaj +1 more source
Molecular Pain, 2009 Background Morphine and its derivatives are key drugs in pain control. Despite its well-known analgesic properties morphine at high concentrations may be proalgesic.
Messlinger Karl +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source