Results 51 to 60 of about 12,370,091 (268)

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]

, 2013
The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Poyner, David, Reynolds, Christopher A., Hay, Debbie L., Poyner, David R, Karakullukcu, Z. Gamze, Woolley, Michael J, Barwell, James, Karakullukcu, Z Gamze, Poyner, David R., Smith, Kevin J., Taddese, Bruck, Reynolds, Christopher A, Conner, Alex C., Hay, Debbie L, Watkins, Harriet A., Watkins, Harriet A, Conner, Alex C, Smith, Kevin J, Woolley, Michael J.   +18 more
core   +1 more source

Distinct Patterns of Internalization of Different Calcitonin Gene-Related Peptide Receptors

, 2020
Calcitonin gene-related peptide (CGRP) is a neuropeptide that is involved in the transmission of pain. Drugs targeting CGRP or a CGRP receptor are efficacious in the treatment of migraine.
Andrew Siow (4768143), Joseph J. Gingell (8544822), Tayla A. Rees (5183762), Paul W. R. Harris (8097566), Margaret A. Brimble (574926), David Rennison (2338186), Christopher S. Walker (4369444), Erica R. Hendrikse (5183756), John Scotter (8544825), Debbie L. Hay (2323294)   +9 more
core   +2 more sources

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

The role of calcitonin gene-related peptide in the endothelin-1 mediated pain perception [PDF]

, 2013
The Role of Calcitonin Gene-Related Peptide in the Endothelin-1 mediated Pain Perception In vessels calcitonin gene-related peptide (CGRP) has an anti-endothelinergic effect by terminating the binding between the endothelin-A (ET-A) receptor and ...
Gianella, Manuela Maria
core   +2 more sources

Lafutidine Facilitates Calcitonin Gene-Related Peptide (CGRP) Nerve-Mediated Vasodilation via Vanilloid-1 Receptors in Rat Mesenteric Resistance Arteries

Journal of Pharmacological Sciences, 2008
Lafutidine is a histamine H2-receptor antagonist with gastric antisecretory and gastroprotective activity associated with activation of capsaicin-sensitive nerves.
Tetsuhiro Sugiyama, Yukako Hatanaka, Yukiko Iwatani, Xin Jin, Hiromu Kawasaki   +4 more
doaj   +1 more source

Role of PACAP in migraine: An alternative to CGRP?

Neurobiology of Disease, 2023
Migraine is a widespread and debilitating neurological condition affecting more than a billion people worldwide. Thus, more effective migraine therapies are highly needed. In the last decade, two endogenous neuropeptides, calcitonin gene-related peptide (
Song Guo, Inger Jansen-Olesen, Jes Olesen, Sarah Louise Christensen   +3 more
doaj   +1 more source

Both Radiofrequency Microtenotomy and Physical Therapy Provide Significant Improvements in Patients With Chronic Midportion Achilles Tendinopathy at a Minimum 5‐Year Follow‐Up

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate a minimum 5‐year follow‐up of patients who were treated with either bipolar radiofrequency microtenotomy (RFM) or physical therapy (PT) for midportion Achilles tendinopathy between 2016 and 2018. Methods All subjects who participated in a previous randomized controlled trial (n = 38) between 2016 and 2018 were invited to fill out a ...
Hayat Jirde Ali, Khaled Meknas, Jüri‐Toomas Kartus, Dana Meknas   +3 more
wiley   +1 more source

Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain

Cell Reports, 2019
Summary: Spinal long-term potentiation (LTP) at C-fiber synapses is hypothesized to underlie chronic pain. However, a causal link between spinal LTP and chronic pain is still lacking. Here, we report that high-frequency stimulation (HFS; 100 Hz, 10 V) of
Li-Jun Zhou, Jiyun Peng, Ya-Nan Xu, Wei-Jie Zeng, Jun Zhang, Xiao Wei, Chun-Lin Mai, Zhen-Jia Lin, Yong Liu, Madhuvika Murugan, Ukpong B. Eyo, Anthony D. Umpierre, Wen-Jun Xin, Tao Chen, Mingtao Li, Hui Wang, Jason R. Richardson, Zhi Tan, Xian-Guo Liu, Long-Jun Wu   +19 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Antimicrobial Neuropeptides and Their Receptors: Immunoregulator and Therapeutic Targets for Immune Disorders

Molecules
The interaction between the neuroendocrine system and the immune system plays a key role in the onset and progression of various diseases. Neuropeptides, recognized as common biochemical mediators of communication between these systems, are receiving ...
Kaiqi Chen, Xiaojun Wu, Xiaoke Li, Haoxuan Pan, Wenhui Zhang, Jinxi Shang, Yinuo Di, Ruonan Liu, Zhaodi Zheng, Xitan Hou   +9 more
doaj   +1 more source